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Study of diagnosis and spatial epidemiology on paragonimiasis in Lao PDR.

Research Project

Project/Area Number 16390188
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionResearch Institute, International Medical Centre of Japan

Principal Investigator

NAKAMURA Satoshi  International Medical Centre of Japan, Research Institute, Chief of division, 室長 (40207874)

Co-Investigator(Kenkyū-buntansha) CHIGUSA Yuichi  Dokkyo University, School of Medicine, Associate Professor, 医学部, 准教授 (20171936)
HABE Shigehisa  Fukuoka University, Faculty of Medicine, Lecturer, 医学部, 講師 (70037430)
MIYOSHI Miki  National Institute of Health and Nutrition, Special researcher, 特別研究員 (30361463)
NIHEI Naoko  National Institute of Infectious Diseases, Visiting researcher, 客員研究員 (70425677)
SUZUKI Kotoko  Tokyo Gakugei University, Faculty of Education, Lecturer, 教育学部, 講師 (90320051)
中田 光  新潟大学, 医歯学総合病院・生命科学医療センター, 教授 (80207802)
Project Period (FY) 2004 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥12,700,000 (Direct Cost: ¥12,700,000)
Fiscal Year 2006: ¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2005: ¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2004: ¥6,100,000 (Direct Cost: ¥6,100,000)
KeywordsInfectious disease / Social Medicien / Parasitology / Applied zoology / Ecology / Geographic Information System / 応用動物 / ラオス / 肺吸虫症 / 診断 / 空間疫学 / 中間宿主
Research Abstract

In spite of lack of information on paragonimiasis in Laos since 1973, eight districts in 5 provinces; Attopeu, Champasak, Savannakhet, Vientiane, and Luangnamtha, which exist and/or possible risk of the disease were clarified through our research. Around 700 metacercariae were collected from 2 species of the river crabs (7 Potamon lipkei and 5 Chulathelphusa brandti) obtained in Hinheup district which was especially investigated as a dense infested area in Vientiane province, where is 80 km north from Vientiane Capital in Lao PDR. Though the numbers were smaller, Paragonimus heterotremus, a known causative species of human parogonimiasis in Indochina region, and P. westermani were identified at the metacercariae population. On the major population, 2 unreported Paragonimus species of harinastai and bankokensis were identified and clarified using adult worms obtained from experimental infections of dogs in the laboratory. Among various experimental animals, adult worms of P. harinastai never survive after 3 month of the experimental infections in rats, which was demonstrated for the first time. Furthermore, dog is a suitable host for P. bankokensis was confirmed by recovery (80%) of the adult worms at the experimental infections. And the established PCR technology was used. To identify the actual causative species of human paragonimiasis in Hinheup, 6 samples of the parasite eggs from the sputa of dwellers were collected, and the established PCR technique; using primers of species specific region (ITS2) of the 4 parasites, was performed. All these samples resulted in P. heterotremus, thus the causative parasite of human paragonimiasis was strongly suggested as this species in the region.

Report

(4 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (26 results)

All 2007 2006 2005 Other

All Journal Article (23 results) Book (3 results)

  • [Journal Article] Paragonimiasis and its intermediate hosts in a transmission focus in Lao PDR.2007

    • Author(s)
      P.Odermatt, S.Habe, S.Nakamura et al.
    • Journal Title

      Acta Tropica (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Paragonimiasis and its intermediate hosts in a transmission focus in Lao PDR.2007

    • Author(s)
      P.Odermatt, et al.
    • Journal Title

      Acta Tropica (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Identification of human Paragonimus species collected from Laotian patients.2006

    • Author(s)
      S.Yahiro, S.Habe, S.Nakamura et al.
    • Journal Title

      11^<th> International Congress of Parasitology, Glasgow, UK : Abstract book (CD-R)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] ラオスにおける人肺吸虫症の原因種の同定2006

    • Author(s)
      波部重久, 八尋伸一郎, 中村 哲
    • Journal Title

      Tropical Medicine and Health 34(増刊号)

      Pages: 168-168

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Identification of human Paragonimus species collected from Laotian patients.2006

    • Author(s)
      S.Yahiro, S.Habe, S.Nakamura et al.
    • Journal Title

      11^<th> International Congress of Parasitology (Glasgow, UK) (Abstract book, CD-R)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Identification of human Paragonimus species collected from Laotian patients.2006

    • Author(s)
      S.Habe, S.Yahiro, S.Nakamura et al.
    • Journal Title

      Tropical Medicine and Health 34

      Pages: 168-168

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Identification of human Paragonimus species collected from Laotian patients. (Poster presentation)2006

    • Author(s)
      S.Yahiro, et al.
    • Journal Title

      11th. International Congress of Parasitology, Glasgow, UK : (Abstract book CD-R版)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] ラオスにおける人肺吸虫症の原因種の同定(学会発表)2006

    • Author(s)
      波部重久, 八尋伸一郎, 中村 哲
    • Journal Title

      第47回日本熱帯医学会総会抄録集(熱帯医学特別号) 34

      Pages: 168-168

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Paragonimus harinastaiの動物体内での発育(学会発表)2006

    • Author(s)
      波部重久, 八尋伸一郎, 中村 哲
    • Journal Title

      第59回日本寄生虫学会南日本支部会抄録集

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Distribution of Paragonimus species in the crab hosts at Vientiane Capital in Lao People's Democratic Republic.2005

    • Author(s)
      S.Habe, S.Nakamura et al.
    • Journal Title

      Medicine and Health in the Tropics, Marseille, France-Abstract book

      Pages: 281-281

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] ラオスにおける肺吸虫症2005

    • Author(s)
      波部重久, 中村 哲, 他
    • Journal Title

      Tropical Medicine and Health 33(増刊号)

      Pages: 82-82

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Distribution of Paragonimus species in the crab hosts at Vientiane Capital in Lao People's Democratic Republic.2005

    • Author(s)
      S.Habe, S.Nakamura et al.
    • Journal Title

      Medicine and Health in the Tropics (Marseille, France) (Abstract book)

      Pages: 281-281

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Paragonimiasis in Lao PDR.2005

    • Author(s)
      S.Habe, S.Nakamura et al.
    • Journal Title

      Tropical Medicine and Health 33

      Pages: 82-82

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Distribution of Paragonimus species in the crab hosts at Vientiane Capital in Lao Peoples Democratic Republic.2005

    • Author(s)
      S.Habe et al.
    • Journal Title

      Medicine and Health in the Tropics, Marseille, France : Abstract Book (Poster presentation)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] ラオスにおける肺吸虫症2005

    • Author(s)
      波辺重久, 中村哲, 他
    • Journal Title

      第46回日本熱帯医学会総会抄録集(熱帯医学特別号) (学会発表)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] ラオスの肺吸虫種について2005

    • Author(s)
      波辺重久, 中村哲, 他
    • Journal Title

      第58回日本熱帯医学会南日本支部会抄録集 (学会発表)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Identification of human Paragonimus species collected from Laotian patients.

    • Author(s)
      S.Yahiro, S.Habe, S.Nakamura et al.
    • Journal Title

      Parasitology Research (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Paragonimiasis and its intermediate hosts in a transmission focus in Lao PDR.

    • Author(s)
      P.Odermatt, S.Habe, S.Nakamura et al.
    • Journal Title

      Acta Tropica 2007 (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Identification of human Paragonimus species collected from Laotian patients.

    • Author(s)
      S.Yahiro, S.Habe, S.Nakamura et al.
    • Journal Title

      Parasitology Research (in submission)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Paragonimiasis and its intermediate hosts in a transmission focus in Lao PDR.

    • Author(s)
      P.Odermatt, et al.
    • Journal Title

      Acta Tropica (投稿中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Identification of human paragonimus species collected from Laotian patients.

    • Author(s)
      S.Yahiro, et al.
    • Journal Title

      Parasitology Research (投稿中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Distribution of Paragonimus species in the crab host at Vientiane Capital in Lao People's Democratic Republic

    • Author(s)
      Satoshi Nakamura, Shigehisa Habe, et al.
    • Journal Title

      Parasitology (発表予定)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Epidemiological study on Paragonimiasis in Lao P.D.R.

    • Author(s)
      Satoshi Nakamura, Shigehisa Habe, et al.
    • Journal Title

      Tropical Medicine and International Health (発表予定)

    • Related Report
      2004 Annual Research Report
  • [Book] 秋道智彌 編 図説 メコンの世界2007

    • Author(s)
      中村 哲
    • Total Pages
      147
    • Publisher
      弘文堂、東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] Trematodes, Foods and Water, In : World of Mekong (Tomoya Akimichi (Ed), 102-103)2007

    • Author(s)
      Satoshi Nakamura
    • Total Pages
      147
    • Publisher
      KOBUN DO, Tokyo
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 図説 メコンの世界(秋道智彌 編)2007

    • Author(s)
      中村 哲
    • Total Pages
      147
    • Publisher
      弘文堂
    • Related Report
      2006 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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