| Project/Area Number |
16390189
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Nagoya University (2006-2007)
Aichi Cancer Center Research Institute (2004-2005) |
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Principal Investigator |
WAKAI Kenji Nagoya University, Graduate School of Medicine, Associate Professor (50270989)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAMURA Takashi Kyoto University, Health Service, Professor (10252230)
NAITO Mariko Nagoya University, Graduate School of Medicine, Associate Professor (10378010)
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| Project Period (FY) |
2004 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥14,550,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2005: ¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2004: ¥8,400,000 (Direct Cost: ¥8,400,000)
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| Keywords | oral health / dentist / cohort study / tooth loss / nutrient intake / mortality / stroke / ischemic heart disease / 食品群摂取状況 / 死亡率比 / 罹患率比 / 歯周病 / 喫煙 / 糖尿病 / 高血圧 / 栄養摂取 |
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| Research Abstract |
To elucidate the relevance of oral health with subsequent risk of lifestyle-related diseases, we are conducting a cohort study in Japanese dentists. The information on oral status could be collected with a self-administered questionnaire from the participants, and they have been followed-up through their affiliated dental associations. In this project, we examined the correlates of tooth loss and the association between tooth loss and nutrient intake in a cross-sectional study utilizing the baseline data In addition, the associations of tooth loss with the total mortality and the incidence of stroke and ischemic heart diseases were assessed by analyzing the cohort data. A total of 21,272 dentists (mean age ± SD, 522 ± 12.3 years ; women, 8.0%) participated in this study Age, female sex, smoking, history of diabetes, and systolic blood pressure were positively correlated with the risk of tooth loss (≧5 teeth) while use of floss, frequency of sealing, and vigorous exercise were inversely linked to the risk The adjusted geometric means in nutrient intakes were higher among those with more present teeth except for carbohydrate. The significantly increased risk of total death (age and sex-adjusted mortality rate ratio, 1.3-1.6) was found in relation to the loss of more than five teeth compared with that of less than five. Although the adjustment for confounding factors attenuated this association, the higher mortality rate ratio was still observed in those with more tooth loss. The age and sex-adjusted risk of incident stroke was also correlated with the number of lost teeth, but the correlation was attenuated after adjustment for other confounders. Although a further follow-up is warranted, this study suggests the bilateral association between oral health and general wellbeing.
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