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Molecular pathogenesis of chronic pancreatitis: CFTR and intraductal sensor molecules

Research Project

Project/Area Number 16390206
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionNagoya University

Principal Investigator

NARUSE Satoru  Nagoya University, Graduate School of Medicine, Associate Professor, 大学院医学系研究科, 助教授 (50180550)

Co-Investigator(Kenkyū-buntansha) KONDO Takaharu  Research Center of Health, Physical Fitness, and Sports, Professor, 総合保健体育科学センター, 教授 (20135388)
ISHIGURO Hiroshi  Research Center of Health, Physical Fitness, and Sports, Associate Professor, 総合保健体育科学センター, 助教授 (90303651)
NAGAO Shizuko  Fujita Health University, Education and Research Center of Animal Models for Human Diseases, Assistant Professor, 疾患モデル教育研究センター, 講師 (20183527)
FURUYA Sonoko  National Insitute for Physiological Sciences, Research Associate, 生理学研究所, 助手 (20096952)
NAGAHAMA Masato  Suzuka University of Medical Science, Medical Engineering, Professor, 医用工学部, 教授 (50198355)
Project Period (FY) 2004 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥14,200,000 (Direct Cost: ¥14,200,000)
Fiscal Year 2006: ¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2005: ¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2004: ¥8,600,000 (Direct Cost: ¥8,600,000)
Keywordschronic pancreatitis / water tranport / HCO_3- transport / CFTR / Na^+-H^+ exchange (NHE) / SLC26 transporters / cystic fibrosis / fibrocystin / 遺伝子変異 / RNAi / SLC26 / 遺伝子多型 / センサー分子
Research Abstract

In order to elucidate molecular pathogenesis of chronic pancreatitis, we investigated functional effects of mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) and other ion transporters and fibrocystin.
1. The entire coding regions of the CFTR gene were analyzed in 65 patients with chronic pancreatitis. Pancreatitis-associated mutations or polymorphisms were identified.
2. A finger sweat chloride test, using a highly sensitive chloride electrode, was developed for detecting a high-risk group of chronic pancreatitis.
3. A reciprocal regulatory interaction between CFTR and SLC26 transporters (SLC26A3 and SLC26A6) was demonstrated in HEK293 cells.
4. Mouse slc26a3 mediated a coupled 2C1^-11HCO_3exchanger, while slc26a6 acted as a 1C^-/2HCO_3exchanger.
5. The entire sequence of the guinea pig CFTR gene was determined. Specific RNA interference of the CFTR reduced pancreatic ductal fluid secretion by 50%.
6. Short-chain n-alcohol augmented or reduced pancreatic ductal fluid secretion by activating or inhibiting plasma membrane Ca^<2+> channel.
7. The Na^+-H^+ exchange played an important role in acidifying pancreatic juice in A ΔF508 CF mice.
8. The developmental morphology of the pancreas in polycystic kidney (PKC) rats with a mutation of the fibrocystin gene was examined. Abnormal Ca^<2+> signal and fluid responses were observed in pancreatic ducts isolated from PKC rats.

Report

(4 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (68 results)

All 2007 2006 2005 2004

All Journal Article (62 results) Book (6 results)

  • [Journal Article] Identification of key residues that cause differential gallbladder response to PACAP and VIP in the guinea pig.2007

    • Author(s)
      Wei M, et al.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol. 292

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Is genetic analysis helpful for diagnosing chronic pancreatitis in its early stage?2007

    • Author(s)
      Naruse S, et al.
    • Journal Title

      J Gastroenterol. 42 Suppl.17

      Pages: 60-65

    • NAID

      10018540047

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Is genetic analysis helpful for diagnosing chronic pancreatitis in its early stage?2007

    • Author(s)
      Naruse S, et al.
    • Journal Title

      J Gastroenterol. 42

    • NAID

      10018540047

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] CFTR dysfunction and chronic pancreatitis, In Annual Review Gastroenterology 2007. (Japanese)2007

    • Author(s)
      Ishiguro H, et al.
    • Journal Title

      Chugai-Igakusha

      Pages: 264-264

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Is genetic analysis helpful for diagnosing chronic pancreatitis in its early stage?2007

    • Author(s)
      Naruse S, et al.
    • Journal Title

      J Gastroenterol. 42 Suppl 17

      Pages: 60-65

    • NAID

      10018540047

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Aquaporin 1 immunoreactive enteric neurons in the rat ileum.2006

    • Author(s)
      Nagahama M, et al.
    • Journal Title

      Neurosci Lett. 395

      Pages: 206-210

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Coupling modes and stoichiometry of Cl^-/HCO_3^- exchange by slc26a3 and slc26a6.2006

    • Author(s)
      Shcheynikov N, et al.
    • Journal Title

      J Gen Physiol. 127

      Pages: 511-524

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Sweat chloride measurement with a highly sensitive electrode2006

    • Author(s)
      Naruse S, et al.
    • Journal Title

      Pancreas 33

      Pages: 100-100

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Fecal pancreatic elastase : a reproducible marker for severe exocrine pancreatic insufficiency.2006

    • Author(s)
      Naruse S, et al.
    • Journal Title

      J Gastroenterol. 41

      Pages: 901-908

    • NAID

      10020626404

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] CFTR遺伝子変異2006

    • Author(s)
      成瀬 達
    • Journal Title

      肝胆膵 53

      Pages: 489-494

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Aquaporin 1 immunoreactive enteric neurons in the rat ileum.2006

    • Author(s)
      Nagahama M, et al.
    • Journal Title

      Neurosci Lett. 13

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Coupling modes and stoichiometry of C1^-/HCO_3^-exchange by slc26a3 and slc26a6.2006

    • Author(s)
      Shcheynikov N, et al.
    • Journal Title

      J Gen Physiol. 127

      Pages: 511-524

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Sweat chloride measurement with a highly sensitive electrode.2006

    • Author(s)
      Naruse S, et al.
    • Journal Title

      Pancreas 33

      Pages: 100-100

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Regulation of exocrine pancreatic function, In Annual Review Gastroenterology 2006. (Japanese)2006

    • Author(s)
      Naruse S.
    • Journal Title

      Chugai-Igakusha

      Pages: 353-353

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Fecal pancreatic elastase : a reproducible marker for severe exocrine pancreatic insufficiency.2006

    • Author(s)
      Naruse S, et al.
    • Journal Title

      J Gastroenterol 41

      Pages: 901-908

    • NAID

      10020626404

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6.2006

    • Author(s)
      Shcheynikov N, et al.
    • Journal Title

      J Gen Physiol. 127

      Pages: 511-524

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Aquaporin 1 immunoreactive enteric neurons in the rat ileum.2006

    • Author(s)
      Nagahama M, Ma N, Naruse S, et al.
    • Journal Title

      Neurosci Lett. 395

      Pages: 206-210

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Sweat chloride measurement with a highly sensitive electrode2006

    • Author(s)
      Naruse S, Ishiguro H, Kondo T, et al.
    • Journal Title

      Pancreas (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Dual effects of n-alcohols on fluid secretion from guinea pig pancreatic ducts.2005

    • Author(s)
      Hamada H, et al.
    • Journal Title

      Am J Physiol Cell Physiol. 288

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Nutritional factors and risk of pancreatic cancer : a population-based case-control study based on direct interview in Japan.2005

    • Author(s)
      Lin Y, et al.
    • Journal Title

      J Gastroenterol. 40

      Pages: 297-301

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Where is the primary site of action of CCK for initiating sphincter of Oddi relaxation?2005

    • Author(s)
      Naruse S.
    • Journal Title

      J Gastroenterol. 40

      Pages: 440-442

    • NAID

      10015710279

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] 日本人のCFTR遺伝子変異と多型-慢性膵炎患者の解析から-2005

    • Author(s)
      成瀬 達
    • Journal Title

      Therapeutic Research 26

      Pages: 1461-1466

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] アルコール性膵障害の発症機序と病態2005

    • Author(s)
      成瀬 達
    • Journal Title

      肝胆膵 51

      Pages: 927-933

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 急性膵炎に対する新しい生化学マーカー2005

    • Author(s)
      成瀬 達
    • Journal Title

      肝胆膵 51

      Pages: 1043-1048

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 慢性膵炎の診断と治療へのアプローチ2005

    • Author(s)
      成瀬 達
    • Journal Title

      細胞 37

      Pages: 298-299

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] CFTRによる重炭酸イオン分泌とその機能障害2005

    • Author(s)
      石黒 洋, 他
    • Journal Title

      細胞 37

      Pages: 305-308

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 膵石症の疫学2005

    • Author(s)
      成瀬 達
    • Journal Title

      胆と膵 26

      Pages: 865-868

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Diagnostic and therapeutic approach for chronic pancreatitis. (Japanese)2005

    • Author(s)
      Naruse S.
    • Journal Title

      The Cell 37

      Pages: 298-299

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Bicarbonate transport by the CFTR and its dysfunction. (Japanese)2005

    • Author(s)
      Ishiguro H, et al.
    • Journal Title

      The Cell 37

      Pages: 305-308

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Epidemiology of pancreatolithiasis? (Japanese)2005

    • Author(s)
      Naruse S.
    • Journal Title

      Tan to Sui 26

      Pages: 865-868

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Water transport in the liver, biliary tract, and pancreas, In Water pathway "Aquaporin" in health and disease. (Japanese)2005

    • Author(s)
      Naruse S.
    • Journal Title

      Kubapuro.

      Pages: 183-183

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Structure and function of the pancreas. In Pancreatic cancer. (Japanese)2005

    • Author(s)
      Naruse S.
    • Journal Title

      Iyaku-Journal.

      Pages: 103-103

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Dual effects of n-alcohols on fluid secretion from guinea pig pancreatic ducts.2005

    • Author(s)
      Hamada H, Ishiguro H, Naruse S, et al.
    • Journal Title

      Am J Physiol Cell Physiol. 288

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Nutritional factors and risk of pancreatic cancer : a population-based case-control study based on direct interview in Japan.2005

    • Author(s)
      Lin Y, Tamakoshi A, Naruse S, et al.
    • Journal Title

      J Gastroenterol. 40

      Pages: 297-301

    • NAID

      10015572598

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Dual effects of n-alcohols on fluid secretion from guinea-pig pancreatic ducts2005

    • Author(s)
      Hamada H, Ishiguro H, Naruse S, et al.
    • Journal Title

      Am J Physiol Cell Physiol (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] A finger sweat chloride test for the detection of a high-risk group of chronic pancreatitis.2004

    • Author(s)
      Naruse S, et al.
    • Journal Title

      Pancreas 28

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Genetic evidence for CFTR dysfunction in Japanese : background for chronic pancreatitis.2004

    • Author(s)
      Fujiki K, et al.
    • Journal Title

      J Med Genet. 41

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Gating of CFTR by the STAS domain of SLC26 transporters.2004

    • Author(s)
      Ko SB, et al.
    • Journal Title

      Nat Cell Biol. 6

      Pages: 343-350

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Dynamic control of cystic fibrosis transmembrane conductance regulator Cl^-/HCO_3^- selectivity by external Cl^-.2004

    • Author(s)
      Shcheynikov N, et al.
    • Journal Title

      J Biol Chem. 279

      Pages: 21857-21865

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Do CFTR gene polymorphisms determine the susceptibility to alcoholic chronic pancreatitis?2004

    • Author(s)
      Naruse S.
    • Journal Title

      Intern Med. 43

      Pages: 1093-1094

    • NAID

      10014209656

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 急性膵炎の治療戦略2004

    • Author(s)
      成瀬 達
    • Journal Title

      日本内科学会雑誌 93

      Pages: 16-23

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 慢性膵炎2004

    • Author(s)
      成瀬 達
    • Journal Title

      膵臓 19

      Pages: 16-20

    • NAID

      10013598664

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 急性膵炎2004

    • Author(s)
      成瀬 達
    • Journal Title

      消化器の臨床 7

      Pages: 275-277

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 尿中トリプシノーゲン活性ペプチド(TAP)2004

    • Author(s)
      成瀬 達
    • Journal Title

      日本臨床 62

      Pages: 131-132

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 急性膵炎診断基準および急性膵炎重症度判定基準による病態評価法2004

    • Author(s)
      成瀬 達
    • Journal Title

      日本臨床 62

      Pages: 2027-2032

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A finger sweat chloride test for the detection of a high-risk group of chronic pancreatitis.2004

    • Author(s)
      Naruse S, et al.
    • Journal Title

      Pancreas. 28

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Dynamic control of cystic fibrosis transmembrane conductance regulator C1^-/HCO_3^- selectivity by external Cl^-.2004

    • Author(s)
      Shcheynikov N, et al.
    • Journal Title

      J Biol Chem. 279

      Pages: 21857-21865

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Do CFTR gene polymorphisms determine the susceptibility to alcoholic chronic pancreatitis?2004

    • Author(s)
      Naruse S.
    • Journal Title

      Intern Med 43

      Pages: 1093-1094

    • NAID

      10014209656

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Therapeutic strategy for acute pancreatitis. (Japanese)2004

    • Author(s)
      Naruse S.
    • Journal Title

      Nihon Naikagakkai Zasshi 93

      Pages: 16-23

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Chronic pancreatitis. (Japanese)2004

    • Author(s)
      Naruse S.
    • Journal Title

      Suizou 19

      Pages: 16-20

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Acute pancreatitis. (Japanese)2004

    • Author(s)
      Naruse S.
    • Journal Title

      Clinics in Gstroenterol. 7

      Pages: 275-277

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Urinary trypsinogen activation peptide (TAP). (Japanese).2004

    • Author(s)
      Naruse S.
    • Journal Title

      Nippon Rinsho. 62

      Pages: 131-132

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Diagnostic criteria for acute pancreatitis and evaluation of the severity. (Japanese)2004

    • Author(s)
      Naruse S.
    • Journal Title

      Nippon Rinsho 62(11)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] CFTR mutations and polymorphisms in Japanese-analysis in chronic pancreatitis (Japanese).2004

    • Author(s)
      Naruse S.
    • Journal Title

      Therapeutic Res 26

      Pages: 1461-1466

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Pathogenesis and pathophysiology of alcoholic chronic pancreatitis? (Japanese)2004

    • Author(s)
      Naruse S.
    • Journal Title

      Kan Tan Sui 51

      Pages: 927-933

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] New diagnostic markers of aute pancreatitis (Japanese)2004

    • Author(s)
      Naruse S.
    • Journal Title

      Kan Tan Sui 51

      Pages: 1043-1048

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] CFTR gene mutation. (Japanese)2004

    • Author(s)
      Naruse S.
    • Journal Title

      Kan Tan Sui 53

      Pages: 489-494

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Gating of CFTR by the STAS domain of SLC26 transporters2004

    • Author(s)
      Ko SB, Naruse S, Muallem S, et al.
    • Journal Title

      Nat Cell Biol 6(4)

      Pages: 292-294

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Dynamic control of cystic fibrosis transmembrane conductance regulator Cl^/HCO_3^- selectivity by external Cl^-.2004

    • Author(s)
      Shcheynikov N, Naruse S, Muallem S, et al.
    • Journal Title

      J Biol Chem 279(21)

      Pages: 390-397

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Genetic evidence for CFTR dysfunction in Japanese : background for chronic pancreatitis2004

    • Author(s)
      Fujiki K, Ishiguro H, Kondo T, Naruse S, et al.
    • Journal Title

      J Med Genet 41(5)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] A finger sweat chloride test for the detection of a high-risk group of chronic pancreatitis2004

    • Author(s)
      Naruse S, Ishiguro H, Kondo T, et al.
    • Journal Title

      Pancreas 28(3)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Do CFTR gene polymorphisms determine the susceptibility to alcoholic chronic pancreatitis?2004

    • Author(s)
      Naruse S.
    • Journal Title

      Intern Med 43(12)

      Pages: 1093-1094

    • NAID

      10014209656

    • Related Report
      2004 Annual Research Report
  • [Book] Annual Review 2006消化器(分担執筆)CFTRの機能異常と慢性膵炎2007

    • Author(s)
      石黒 洋, 他
    • Total Pages
      264
    • Publisher
      中外医学社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] CFTRの機能異常と慢性膵炎, Annual Review 2007消化器(分担執筆)2007

    • Author(s)
      石黒 洋, 他
    • Total Pages
      264
    • Publisher
      中外医学社
    • Related Report
      2006 Annual Research Report
  • [Book] Annual Review 2006消化器(分担執筆)膵外分泌調節機構2006

    • Author(s)
      成瀬 達
    • Total Pages
      353
    • Publisher
      中外医学社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 膵外分泌調節機構, Annual Review 2006消化器(分担執筆)2006

    • Author(s)
      成瀬 達, 石黒 洋
    • Total Pages
      253
    • Publisher
      中外医学社
    • Related Report
      2005 Annual Research Report
  • [Book] みずみずしい体のしくみ-水の通り道「アクアポリン」の働きと病気(分担執筆)肝胆膵における水の流れ2005

    • Author(s)
      成瀬 達
    • Total Pages
      183
    • Publisher
      クバプロ
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 膵がん(分担執筆)膵臓の構造と機能2005

    • Author(s)
      成瀬 達
    • Total Pages
      103
    • Publisher
      医薬ジャーナル社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary

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Published: 2004-04-01   Modified: 2016-04-21  

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