| Project/Area Number |
16390214
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | JICHI MEDICAL SCHOOL |
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Principal Investigator |
SUGANO Kentaro JICHI MEDICAL SCHOOL, School of Medicine, Professor, 医学部, 教授 (60179116)
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| Co-Investigator(Kenkyū-buntansha) |
SATOH Kiichi JICHI MEDICAL SCHOOL, School of Medicine, Senior Lecturer, 医学部, 講師 (50275707)
MUTOH Hiroyuki JICHI MEDICAL SCHOOL, School of Medicine, Senior Lecturer, 医学部, 講師 (50322392)
OSAWA Hiroyuki JICHI MEDICAL SCHOOL, School of Medicine, Assistant Lecturer, 医学部, 助手 (70260833)
岩本 美智子 自治医科大学, 医学部, 助手
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥14,400,000 (Direct Cost: ¥14,400,000)
Fiscal Year 2005: ¥4,200,000 (Direct Cost: ¥4,200,000)
Fiscal Year 2004: ¥10,200,000 (Direct Cost: ¥10,200,000)
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| Keywords | Intestinal Metaplasia / Gastric Cancer / Transgenic mouse / Transcriptional Factor / Cdx1, 2 / Math 1 / Sonic Hedgehog / 分化型胃癌 / CDX / SHH |
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| Research Abstract |
Intestinal metaplasia has been considered as a condition predisposing cancer development.
However, no direct evidence on cancer development from intestinal metaplasia has been provided.
In this research project, we could demonstrate that gastric adenocarcinoma with differentiated histological features developed from intestinal metaplasia in the cdx-2 expressing transgenic mice stomach. The analysis of genetic alteration revealed that mutational events frequently observed in human gastric cancer (such as p53 or APC gene mutations or truncations) occurred in the mice tumors. Therefore, this model will be quite useful for analyzing the molecular events leading to carcinogenesis and also for interventional studies to suppress cancer development.
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