| Project/Area Number |
16390220
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Shinshu University |
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Principal Investigator |
IKEDA Uichi Shinshu University, Department of Organ Regeneration, Professor, 大学院医学系研究科, 教授 (30221063)
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| Co-Investigator(Kenkyū-buntansha) |
AMANO Jun Shinshu University, Department of Surgery, Professor, 医学部, 教授 (20138283)
TAKAHASHI Masafumi Shinshu University, Department of Organ Regeneration, Associate Professor, 大学院医学系研究科, 助教授 (40296108)
ISE Hirohiko Shinshu University, Department of Organ Regeneration, Assistant Professor, 大学院医学系研究科, 助手 (10324253)
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| Project Period (FY) |
2004 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥13,800,000 (Direct Cost: ¥13,800,000)
Fiscal Year 2006: ¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 2005: ¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 2004: ¥5,200,000 (Direct Cost: ¥5,200,000)
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| Keywords | regeneration / atherosclerosis / myocardial infarction / bone marrow / angiogenesis |
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| Research Abstract |
We have previously reported the effectiveness and safety of therapeutic angiogenesis by transplantation of autologous bone marrow mononuclear cells to ischemic limbs (Lancet 2002). In this study, we investigated whether transplantation of bone marrow-derived endothelial progenitor cells (EPCs) would also be effective in patients with ischemic heart disease. Bone marrow-derived EPCs were transplanted to the myocardium in patients with ischemic heart disease ; They received bone marrow-derived CD34^+ cell transplantation into ungraftable regions of the left ventricle with concomitant coronary artery bypass grafts (hybrid therapy). Before and 1 month after cell transplantation, we assessed the regional blood flow by single photon emission computed tomography (SPECT). The blood flow in the EPC-transplanted region as well as the grafted region was significantly increased at 1 month after cell transplantation. No side effects were observed. In this study, we demonstrated that autologous transplantation of bone marrow-derived EPCs represents a new and promising strategy for clinical application designed to revascularize the ischemic myocardium
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