A randomized study to evaluate survival benefit of gefitinib in patients with advanced non-small cell lung cancer and correlation of efficacy and biomarkers

• Project/Area Number: 16390238
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Kinki University
• Principal Investigator: FUKUOKA Masahiro Kinki University, Hospital, Professor, 医学部附属病院, 教授 (20047202)
• Co-Investigator(Kenkyū-buntansha): TAMURA Kenji Kinki University, Hospital, Lecturer, 医学部附属病院, 講師 (60340783) ; HIDA Toyoaki Prefectural Aichi Cancer Center, Assistant director, 副部長 (80250249) ; NAKAGAWA Kazuhiko Kinki University, School of Medicine, Associate professor, 医学部, 助教授 (40298964) ; 倉田 宝保 近畿大学, 医学部, 講師 (40340781) ; 有吉 寛 県立愛知病院, 院長
• Project Period (FY): 2004 – 2006
• Project Status: Completed (Fiscal Year 2006)
• Budget Amount: ¥13,200,000 (Direct Cost: ¥13,200,000); Fiscal Year 2006: ¥3,800,000 (Direct Cost: ¥3,800,000); Fiscal Year 2005: ¥3,800,000 (Direct Cost: ¥3,800,000); Fiscal Year 2004: ¥5,600,000 (Direct Cost: ¥5,600,000)
• Keywords: Lung Cancer / non-small cell cancer / chemotherapy / gefitinib / EGFR / mutation / HER2 / IGFR-1 / 上皮成長因子受容体 / インスリン様成長因子I受容体 / 放射線化学療法 / 局所進行肺がん / イリノテカン / パクリタキセル / カルボプラチン / シスプラチン

Research Abstract

This study was a randomized trial to evaluate the survival benefit of gefitinib, a epidermal growth factor receptor (EGFR) tylosine kinase inhibitor as a maintenance therapy in advanced non-small cell lung cancer (NSCLC). Between March 2003 and July 2005, 604 patients with stage IIIB or IV NSCLC were randomly assigned to receive standard chemotherapy alone or 3 cycles of chemotherapy followed by gefitinib until disease progressin. We carried out a correlative study to determine the relationships between EGFR mutations, EGFR or HER2 protein expressions, their activation status (pEGFR, pHER2) or insulin-like growth factor receptor 1 (IGFR-1) protein expressions and clinical outcomes after gefitinib treatment. Primary endpoint was to detect biomarkers to predict gefitinib sensitivity. One hundred and three consecutive patients were enrolled onto the study. Median age was 68 years, female (58%), adenocarcinoma (83%), and never smoker (55%). 98 patients were evaluable for efficacies, toxicities and gene analyses. Forty-one pts (42%) had EGFR mutations ; 14 pts had deletional mutation in exon 19, 27 pts had missense mutation (L858R) in exon 21. EGFR mutations were significantly related to response (62 vs. 26% ; P = 0.001), disease control rate (92 vs. 65% ; P = 0.003) and TTP (median, 10.1 vs. 5.1months ; hazard ratio = 0.64 ; P = 0.048). Both pEGFR (0, +1 vs. ?+2 ; P = 0.002,) and pHER2 (0 vs. ?+1 ; P = 0.001) expressions were significantly associated with incidence of EGFR mutation. Conclusion : EGFR mutation was a significant predictive biomarker of response to gefitinib. Phosphorylated EGFR protein expression is a potent replaceable biomarker for EGFR mutation.

Research Products

• [Journal Article] Randomized phase III study of cisplatin plus irinotecan versus carb oplatin plus paclitaxel, cisplatin plus gemcitabine, and cisplatin plus vinorelbine for advanced non-small-cell lung cancer : Four-Arm Cooperative Study in Japan. (2007)
  • Author(s): Ohe Y., Ohashi Y., Kubota K., Tamura T., Nakagawa K., Negoro S., Nishiwaki Y., Saijo N., Ariyoshi Y., Fukuoka M.
  • Journal Title: Ann. Oncol. 18(2) Pages: 317-323
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Genomic profiling of malignant pleural mesothelioma with array-based comparative genomic hybridization shows frequent non-random chromosomal alteration regions including JUN amplification on 1p32. (2007)
  • Author(s): Taniguchi T, Karnan S, Fukui T, Yokoyama T, Tagawa H, Yokoi K, Ueda Y, Mitsudomi T, Horio Y, Hida T, Yatabe Y, Seto M, Sekido Y
  • Journal Title: Cancer Sci. 98(3) Pages: 438-446
  • NAID: 10019482069
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Randomized phase III study of cisplatin plus irinotecan versus carboplatin plus paclitaxel, cisplatin plus gemcitabine, and cisplatin plus vinorelbine for advanced non-small-cell lung cancer : Four-Arm Cooperative Study in Japan. (2007)
  • Author(s): Ohe Y., Ohashi Y., Kubota K., Tamura T., Nakagawa K., Negoro S., Nishiwaki Y., Saijo N., Ariyoshi Y., Fukuoka M
  • Journal Title: Ann.Oncol. 18(2) Pages: 317-23
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Genomic profiling of malignant pleural mesothelioma with array-based comparative genomic hybridization shows frequent non-random chromosomal alteration regions including JUN amplification on 1p32. (2007)
  • Author(s): Taniguchi T, Karnan S, Fukui T, Yokoyama T, Tagawa H, Yokoi K, Ueda Y, Mitsudomi T, Horio Y, Hida T, Yatabe Y, Seto M, Sekido Y.
  • Journal Title: Cancer Sci. 98(3) Pages: 438-46
  • NAID: 10019482069
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Randomized phase III study of cisplatin plus irinotecan versus carboplatin plus paclitaxel, cisplatin plus gemcitabine, and cisplatinplus vinorelbine for advanced non-small-cell lung cancer : Four-Arm Cooperative Study in Japan. (2007)
  • Author(s): Ohe Y, Ohashi Y, Kubota K, Tamura T, Nakagawa K, Negoro S, Nishiwaki Y, Saijo N, Ariyoshi Y, Fukuoka M.
  • Journal Title: ann. Oncol. 18(2) Pages: 317-23
• [Journal Article] Genomic profiling of malignant pleural mesothelioma with array-based comparative genomic hybridization shows frequent non-random chromosomal alteration regions including JUN amplification on 1p32. (2007)
  • Author(s): Taniguchi T, Karnana S, Fukui T, Yokoyama T, Tagawa H, Yokoi K, Ueda Y, Mitsudomi T, Horio Y, Hida T, Yatabe Y, Seto M, Sekido Y.
  • Journal Title: Cancer Sci. 98(3) Pages: 438-46
  • NAID: 10019482069
• [Journal Article] Establishment and characterization of four malignant pleural mesot helioma cell lines from Japanese patients. (2006)
  • Author(s): Usami N, Fukui T, Kondo M, Taniguchi T, Yokoyama T, Mori S, Yokoi K, Horio Y, Shimokata K, Sekido Y, Hida T
  • Journal Title: Cancer Sci. 97(5) Pages: 387-394
  • NAID: 10018176905
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Analysis of epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer and acquired resistance to gefitinib. (2006)
  • Author(s): Kosaka T, Yatabe Y, Endoh H, Yoshida K, Hida T, Tsuboi M, Tada H, Kuwano H, Mitsudomi T
  • Journal Title: Clin Cancer Res. 12(19) Pages: 5764-5769
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Small interfering RNA targeting survivin sensitizes lung cancer cell with mutant p53 to adriamycin. (2006)
  • Author(s): Yonesaka K, Tamura K, Kurata T, Satoh T, Ikeda M, Fukuoka M, Nakagawa K
  • Journal Title: Int J Cancer. 118 Pages: 812-820
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Phase II study of weekly paclitaxel for Relapsed and refractory small cell lung cancer. (2006)
  • Author(s): Yamamoto N, Tsurutani J, Yoshimura N, Asai G, Moriyama A, Nakagawa K, Kudou S, Takada M, Minato Y, Fukuoka M
  • Journal Title: Anticancer Res. 26 Pages: 777-781
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A EGFR mutation in gefitinib-responsive small-cell lung cancer. (2006)
  • Author(s): Okamoto I, Araki J, Suto R, Shimada M, Nakagawa K, Fukuoka M
  • Journal Title: Ann Oncol. 17 Pages: 1028-1029
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Phase II Study of Etoposide and Cisplatin With Concurrent Twice-Daily Thoracic Radiotherapy Followed by Irinotecan and Cisplatin in Patients With Limited-Disease Small-Cell Lung Cancer (2006)
  • Author(s): Saito H, Takada Y, Ichinose Y, Eguchi K, Kudoh S, Matsui K, Nakagawa K, Takada M, Negoro S, Tamura K, Ando M, Tada T, Fukuoka M
  • Journal Title: J Clin Oncol. 24(33) Pages: 5247-5252
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Predictive factors for interstitial lung disease, antitumor response, and survival in non-small-cell lung cancer patients treated with gefitinib. (2006)
  • Author(s): Ando M, Okamoto I, Yamamoto N, Takeda K, Tamura K, Seto T, Ariyoshi Y, Fukuoka M
  • Journal Title: J Clin Oncol. 24(16) Pages: 2549-2556
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Randomized Phase II study of Carboplatin/Gemcitabine versus Vinorelbine/Gemcitabine in Patients With Advanced Non small Cell Lung Cancer. West Japan Thoracic Oncology Group(WJTOG) 0104. (2006)
  • Author(s): Yamamoto N., Nakagawa K., Uejima H., Sugiura T., Takada Y., Negoro S., Matsui K., Kashii T., Takada M., Nakanishi Y., Kato T., Fukuoka M.
  • Journal Title: Cancer 107 Pages: 599-605
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Pemetrexed-induced edema of the eyelid. (2006)
  • Author(s): Kurata T., Tamura K., Okamoto I., Satoh T., Nakagawa K., Fukuoka M.
  • Journal Title: Lung Cancer 54 Pages: 241-242
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A phase I study of pemetrexed (LY231514) supplemented with folate and vitamin B12 in Japanese patients with solid tumours. (2006)
  • Author(s): Nakagawa K., Kudoh S., Matsui K., Negoro S., Yamamoto N., Latz J.E., Adachi S., Fukuoka M.
  • Journal Title: Br. J. Cancer 95 Pages: 677-682
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Is the Importance of Achieving Stable Disease Different between Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors and Cytotoxic Agents in the Second-Line Setting for Advanced Non-small Cell Lung Cancer? (2006)
  • Author(s): Kurata T., Matsuo K., Takada M., Kawahara M., Tsuji M., Matsubara Y., Otani N., Matsuyama S., Muraishi K., Fujita T., Ishikawa M., Koyano K., Okamoto I., Satoh T., Tamura K., Nakagawa K., Fukuoka M.
  • Journal Title: Journal of Thoracic Oncology 1 Pages: 684-691
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] EKB-569, a new irreversible epidermal growth factor receptor tyrosine kinase inhibitor, with clinical activity in patients with non-small cell lung cancer with acquired resistance to gefitinib. (2006)
  • Author(s): Yoshimura N., Kudoh S., Kimura T., Mitsuoka S., Matsuura K., Hirata K., Matsui K., Negoro S., Nakagawa K., Fukuoka M.
  • Journal Title: Lung Cancer 51 Pages: 363-368
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Phase III study of docetaxel compared with vinorelbine in elderly patients with advanced non-small-cell lung cancer : results of the West Japan Thoracic Oncology Group Trial (WJTOG 9904) (2006)
  • Author(s): Kudoh S, Takeda K, Nakagawa K, Takada M, Katakami N, Matsui K, Shinkai T, Sawa T, Goto I, Semba H, Seto T, Ando M, Satoh T, Yoshimura N, Negoro S, Fukuoka M
  • Journal Title: J Clin Oncol 24 Pages: 3657-3663
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Phase I and Pharmacokinetic Study of Combination Chemotherapy Using Irinotecan and paclitaxel in Patients with Lung Cancer. (2006)
  • Author(s): Asai, G., Yamamoto, N., Kurata, T., Tamura, K., Uejima, H., Nakagawa, K., Fukuoka, M.
  • Journal Title: J Thorac Oncol. 1 Pages: 226-230
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A Phase I Study of Irinotecan in Combination with Amrubicin for Advanced Lung Cancer Patients. (2006)
  • Author(s): Kaneda, H., Kurata, T., Tamura, K., Uejima, H., Nakagawa, K., Fukuoka, M.
  • Journal Title: Anticancer Res. 26 Pages: 2479-2486
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Establishment and characterization of four malignant pleural mesothelioma cell lines from Japanese patients. (2006)
  • Author(s): Usami N, Fukui T, Kondo M, Taniguchi T, Yokoyama T, Mori S, Yokoi K, Horio Y, Shimokata K, Sekido Y, Hida T.
  • Journal Title: Cancer Sci. 97(5) Pages: 387-394
  • NAID: 10018176905
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Analysis of epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer and acquired resistance to gefitinib. (2006)
  • Author(s): Kosaka T, Yatabe Y, Endoh H, Yoshida K, Hida T, Tsuboi M, Tada H, Kuwano H, Mitsudomi T.
  • Journal Title: Clin Cancer Res. 12(19) Pages: 5764-5769
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Small interfering RNA targeting survivin sensitizes lung cancer cell with mutant p53 to adriamycin. (2006)
  • Author(s): Yonesaka K, Tamura K, Kurata T, Satoh T, Ikeda M, Fukuoka M, Nakagawa K.
  • Journal Title: Int J Cancer 118 Pages: 812-820
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Phase II study of weekly paclitaxel for Relapsed and refractory small cell lung cancer. (2006)
  • Author(s): Yamamoto N, Tsurutani J, Yoshimura N, Asai G, Moriyama A, Nakagawa K, Kudou S, Takada M, Minato Y, Fukuoka M.
  • Journal Title: Anticancer Res 26 Pages: 777-781
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] EGFR mutation in gefitinib-responsive small-cell lung cancer. (2006)
  • Author(s): Okamoto I, Araki J, Suto R, Shimada M, Nakagawa K, Fukuoka M.
  • Journal Title: Ann Oncol 17 Pages: 1028-1029
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Phase II Study of Etoposide and Cisplatin With Concurrent Twice-Daily Thoracic Radiotherapy Followed by Irinotecan and Cisplatin in Patients With Limited- Disease Small-Cell Lung Cancer : West Japan Thoracic Oncology Group 9902. (2006)
  • Author(s): Saito H, Takada Y, Ichinose Y, Eguchi K, Kudoh S, Matsui K, Nakagawa K, Takada M, Negoro S, Tamura K, Ando M, Tada T, Fukuoka M.
  • Journal Title: J Clin Oncol. 24(33) Pages: 5247-5252
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Predictive factors for interstitial lung disease, antitumor response, and survival in non-small-cell lung cancer patients treated with gefitinib. (2006)
  • Author(s): Ando M, Okamoto I, Yamamoto N, Takeda K, Tamura K, Seto T, Ariyoshi Y, Fukuoka M.
  • Journal Title: J Clin Oncol. 24(16) Pages: 2549-2556
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A phase I study of pemetrexed (LY231514) supplemented with folate and vitamin B12 in Japanese patients with solid tumours. (2006)
  • Author(s): Nakagawa K., Kudoh S., Matsui K., Negoro S., Yamamoto N., Latz J.E., Adachi S., Fukuoka M.
  • Journal Title: Br.J.Cancer 95 Pages: 677-682
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] EKB-569, a new irreversible epidermal growth factor receptor tyrosine kinase inhibitor, with clinical activity in patients with non-small cell lung cancer with acquired resistance to gefitinib. (2006)
  • Author(s): Yoshimura N., Kudoh S., Kimura T., Mitsuoka S., Matsuura K., Hirata K., Matsui K., Negoro S., Nakagawa K.Fukuoka M.
  • Journal Title: Lung Cancer 51 Pages: 363-368
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Phase III study of docetaxel compared with vinorelbine in elderly patients with advanced non-small-cell lung cancer : results of the West Japan Thoracic Oncology Group Trial (WJTOG 9904). (2006)
  • Author(s): Kudoh S, Takeda K, Nakagawa K, Takada M, Katakami N, Matsui K, Shinkai T, Sawa T, Goto I, Semba H, Seto T, Ando M, Satoh T, Yoshimura N, Negoro S, Fukuoka M.
  • Journal Title: J Clin Oncol 24 Pages: 3657-3663
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Phase I and Pharmacokinetic Study of Combination Chemotherapy Using Irinotecan and paclitaxel in Patients with Lung Cancer. (2006)
  • Author(s): Asai, G., Yamamoto, N., Kurata, T., Tamura, K., Uejima, H., Nakagawa, K., Fukuoka, M.
  • Journal Title: J Thorac Oncol. (1) Pages: 226-230
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Establishment and characterization of four malignant pleural mesot helioma cell lines from Japanese patients. (2006)
  • Author(s): Usami N, Fukui T, Kondo M, Tanigutchi T, Yokoyama T, Mori S, Yokoi K, Horio Y, Shimokata K, Sekido Y, Hida T.
  • Journal Title: Cancer Sci. 97(5) Pages: 387-94
  • NAID: 10018176905
• [Journal Article] Small interfering RNA targeting survivin sensitizes lung cancer cell with mutant p53 to adriamycin. (2006)
  • Author(s): Yonesaka K, Tamura K, Kurata T, Satoh T, Ikeda M, Fukuoka M, Nakagawa K.
  • Journal Title: Int J Cancer. 118 Pages: 812-820
• [Journal Article] Phase II study of weekly paclitaxel for Relapsed and refractory small cell lung cancer. (2006)
  • Author(s): Yamamoto N, Tsurutani J, Yoshimura N, Asai G, Moriyama A, Nakagawa K, Kudou S, Takada M, Minato Y, Fukuoka M.
  • Journal Title: Anticancer Res. 26 Pages: 777-781
• [Journal Article] A EGFR mutation in gefitinib-responsive small-cell lung cancer. (2006)
  • Author(s): Okamoto I, Araki J, Suto R, Shimada M, Nakagawa K, Fukuoka M.
  • Journal Title: Ann Oncol. 17 Pages: 1028-1029
• [Journal Article] Phase II Study of Etoposide and Cisplatin With Concurrent Twice-Daily Thoracic Radiotherapy Followed by Irinotecan and Cisplatin in Patients With Limited-Disease Small-Cell Lung Cancer : (2006)
  • Author(s): Saito H, Takada Y, Ichinose Y, Eguchi K, Kudoh S, Matsui K, Nakagawa K, Takada M, Negoro S, Tamura K, ando M, Tada T, Fukuoka M.
  • Journal Title: J Clin Oncol. 24(33) Pages: 5247-52
• [Journal Article] Randomized Phase II study of Carboplatin/Gemcitabine versus Vinorelbine/Gemcitabine in Patients With Advanced Non small Cell Lung Cancer. West Japan Thoracic Oncology Group(WJTOG) 0104. (2006)
  • Author(s): Yamamoto N, Nakagawa K, Uejima H, Sugiura T, Takada Y, Negoro S, Matsui K, Kashii T, Takada M, Nakanishi Y, Kato T, Fukuoka M..
  • Journal Title: Cancer 107 Pages: 599-605
• [Journal Article] Pemetrexed-induced edema of the eyelid. (2006)
  • Author(s): Kurata T, Tamura K, Okamoto I, Satoh T, Nakagawa K, Fukuoka M.
  • Journal Title: Lung Cancer 54 Pages: 241-242
• [Journal Article] A phase I study of pemetrexed (LY231514) supplemented with folate and vitamin B12 in Japanese patients with solid tumours. (2006)
  • Author(s): Nakagawa K, Kudoh S, Matsui K, Negoro S, Yamamoto N, Latz J. E, Adachi S, Fukuoka M.
  • Journal Title: Br. J. Cancer 95
• [Journal Article] Is the Importance of Achieving Stable Disease Different between Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors and Cytotoxic Agents in the Second-Line Setting for Advanced Non-small Cell Lung Cancer? (2006)
  • Author(s): Kurata T, Matsuo K, Takada M, Kawahara M, Tsuji M, Matsubara Y, Otani N, Matsuyama S, Muraishi K, Fujita T, Ishikawa M, Koyano K, Okamoto I, Satoh T, Tamura K, Nakagawa K, Fukuoka M.
  • Journal Title: Journal of Thoracic Oncology 1 Pages: 684-691
• [Journal Article] EKB-569, a new irreversible epidermal growth factor receptor tyrosine kinase inhibitor, with clinical activity in patients with non-small cell lung cancer with acquired resistance to gefitinib. (2006)
  • Author(s): Yoshimura N, Kudoh S, Kimura T, Mitsuoka S, Matsuura K, Hirata K, Matsui K, Negoro S, Nakagawa K, Fukuoka M.
  • Journal Title: Lung Cancer 51 Pages: 363-368
• [Journal Article] Phase III study of docetaxel compared with vinorelbine in elderly patients with advanced non-small-cell lung cancer : results of the West Japan Thoracic Oncology Group Trial (WJTOG 9904) (2006)
  • Author(s): Kudoh S, takeda K, Nakagawa K, Takada M, Katakami N, Matsui K, Shinkai T, Sawa T, Goto I, Semba H, Seto T, ando M, Satoh T, Yoshimura N, Negoro S, Fukuoka M
  • Journal Title: J Clin Oncol 24 Pages: 3657-3663
• [Journal Article] Phase I and Pharmacokinetic Study of Combination Chemotherapy Using Irinotecan and paclitaxel in Patients with Lung Cancer. (2006)
  • Author(s): Asai, G, Yamamoto, N, Kurata, T, Tamura, K, Uejima, H, Nakagawa, K, Fukuoka, M.
  • Journal Title: J Thorac Oncol. 1 Pages: 226-230
• [Journal Article] A Phase I Study of Irinotecan in Combination with Amrubicin for Advanced Lung Cancer Patients. (2006)
  • Author(s): Kaneda, H, Kurata, T, Tamura, K, Uejima, H, Nakagawa, K, Fukuoka, M.
  • Journal Title: Anticancer Res. 26 Pages: 2479-2486
• [Journal Article] Small interfering RNA targeting survivin sensitizes lung cancer cell with mutant p53 to adriamycin (2006)
  • Author(s): Yonesaka, K., Tamura, K., Kurata, T., Satoh, T., Ikeda, M., Fukuoka, M., Nakagawa, K.
  • Journal Title: Int J Cancer 118 Pages: 812-820
• [Journal Article] Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence. (2005)
  • Author(s): Mitsudomi T, Kosaka T, Endoh H, Horio Y, Hida T, Mori S, Hatooka S, Shinoda M, Takahashi T, Yatabe Y
  • Journal Title: J Clin Oncol. 23(11) Pages: 2513-2520
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Expression levels of Rab2, a G protein, and Bag-1, a Bcl-2 binding protein are controlled by withdrawal of nicotine from cultured pheochromocytoma PC12 cells. (2005)
  • Author(s): Yamada K, Ishiguro H, Ichino N, Nishii K, Sawada H, Hida T, Nagatsu T
  • Journal Title: J Neural Transm. 112(5) Pages: 633-639
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Irinotecan and etoposide for previously untreated extensive-disease small cell lung cancer : A phase II trial of West Japan Thoracic Oncology Group. (2005)
  • Author(s): Kudoh S, Nakamura S, Nakano T, Komuta K, Isobe T, Katakami N, Fukuda Y, Takada Y, Takada M, Fukuoka M, Ariyoshi Y
  • Journal Title: Lung Cancer. 49 Pages: 263-269
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A phase I/II study comparing regimen schedules of gemcitabine and docetaxel in Japanese patients with stage IIIB/IV non-small cell lung cancer. (2005)
  • Author(s): Mtatsui K, Hirashima T, Nitta T, Kobayashi M, Ogata Y, Furukawa M, Kudoh S, Yoshimura N, Mukohara T, Yamauchi S, Shiraishi S, Kamoi H, Negoro S, Takeda K, Nakagawa K, Takada M, Yana T, Fukuoka M
  • Journal Title: Jpn J Clin Oncol. 35 Pages: 181-187
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Phase I-II study of amrubicin and cisplatin in previously untreated patients with extensive-stage small-cell lung cancer. (2005)
  • Author(s): Ohe Y, Negoro S, Matsui K, Nakagawa K, Sugiura T, Takada Y, Nishiwaki Y, Yokota S, Kawahara M, Saijo N, Fukuoka M, Ariyoshi Y
  • Journal Title: Ann Oncol. 16 Pages: 430-436
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence. (2005)
  • Author(s): Mitsudomi T, Kosaka T, Endoh H, Horio Y, Hida T, Mori S, Hatooka S, Shinoda M, Takahashi T, Yatabe Y.
  • Journal Title: J Clin Oncol. 23(11) Pages: 2513-2520
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Expression levels of Rab2, a G protein, and Bag-1, a Bcl-2 binding protein are controlled by withdrawal of nicotine from cultured pheochromocytoma PC12 cells. (2005)
  • Author(s): Yamada K, Ishiguro H, Ichino N, Nishii K, Sawada H, Hida T, Nagatsu T.
  • Journal Title: J Neural Transm. 112(5) Pages: 633-639
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Irinotecan and etoposide for previously untreated extensive-disease small cell lung cancer : A phase II trial of West Japan Thoracic Oncology Group. (2005)
  • Author(s): Kudoh S, Nakamura S, Nakano T, Komuta K, Isobe T, Katakami N, Fukuda Y, Takada Y, Takada M, Fukuoka M, Ariyoshi Y.
  • Journal Title: Lung Cancer 49 Pages: 263-269
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A phase I/II study comparing regimen schedules of gemcitabine and docetaxel in Japanese patients with stage IIIB/IV non-small cell lung cancer. (2005)
  • Author(s): Matsui K, Hirashima T, Nitta T, Kobayashi M, Ogata Y, Furukawa M, Kudoh S, Yoshimura N, Mukohara T, Yamauchi S, Shiraishi S, Kamoi H, Negoro S, Takeda K, Nakagawa K, Takada M, Yana T, Fukuoka M.
  • Journal Title: Jpn J Clin Oncol 35 Pages: 181-187
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Phase I-II study of amrubicin and cisplatin in previously untreated patients with extensive-stage small-cell lung cancer. (2005)
  • Author(s): Ohe Y, Negoro S, Matsui K, Nakagawa K, Sugiura T, Takada Y, Nishiwaki Y, Yokota S, Kawahara M, Saijo N, Fukuoka M, Ariyoshi Y.
  • Journal Title: Ann Oncol. 16 Pages: 430-436
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Irinotecan and etoposide for previously untreated extensive-disease small cell lung cancer : A phase II trial of West Japan Thoracic Oncology Group. (2005)
  • Author(s): Kudoh, S., Nakamura, S., Nakano, T., Komuta, K., Isobe, T., Katakami, N., Fukuda, Y., Takada, Y., Takada, M., Fukuoka, M., Ariyoshi, Y.
  • Journal Title: Lung Cancer 42 Pages: 263-269
• [Journal Article] A phase I/II study comparing regimen schedules of gemcitabine and docetaxel in Japanese patients with stage IIIB/IV non-small cell lung cancer (2005)
  • Author(s): Matsui, K., Hirashima, T., Nitta, T., Kobayashi, M., Ogata, Y., Furukawa, M., Kudoh, S., Yoshimura, N., Mukohara, T., Yamauchi, S., Shiraishi, S., Kamoi, H., Negoro, S., Takeda, K., Nakagawa, K., Takada, M., Yana, T., Fukuoka, M.
  • Journal Title: Jpn J Clin Oncol 35 Pages: 181-187
• [Journal Article] Phase I-II study of amrubicin and cisplatin in previously untreated patients with extensive-stage small-cell lung cancer (2005)
  • Author(s): Ohe, Y., Negoro, S., Matsui, K., Nakagawa, K., Sugiura, T., Takada, Y., Nishiwaki, Y., Yokota, S., Kawahara, M., Saijo, N., Fukuoka, M., Ariyoshi, Y.
  • Journal Title: Ann Oncol 16 Pages: 430-436
• [Journal Article] Phase I/II study of amrubicin, a novel 9-aminoanthracycline, in patients with advanced non-small-cell lung cancer (2005)
  • Author(s): Sugiura, T., Ariyoshi, Y., Negoro, S., Nakamura, S., Ikegami, H., Takada, M., Yana, T., Fukuoka, M.
  • Journal Title: Invest New Drugs 20 Pages: 331-337
• [Journal Article] Gfitinib in non-small cell lung cancer (2005)
  • Author(s): Tamura, K., Fukuoka, M.
  • Journal Title: Expert Opin Pharmacother 6 Pages: 985-993
• [Journal Article] Randomized phase II study of docetaxel/ cisplatin versus docetaxel / irinotecan in advanced non-small cell lung cancer : a West Japan Thoracic Oncology Study (WJTOG9803). (2004)
  • Author(s): Yamamoto, N., Fukuoka, M., Negoro, S., Nakagawa, K., Saito, H., Matsui, K., Kawahara, M., Senba, H., Takada, Y., Kudoh, S., Nakano, T., Katakami, N., Sugiura, T., Hoso, T., Ariyoshi, Y.
  • Journal Title: Br J Cancer. 90 Pages: 87-92
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effect of re-treatment with gefitinib ('Iressa', ZD1839) after accuisition of resistance. (2004)
  • Author(s): Kurata, T., Tamura, K., Kaneda, H., Nogami, T., Uejima, H., Asai, G., Nakagawa, K., Fukuoka, M.
  • Journal Title: Ann Oncol. 15 Pages: 173-174
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Combination phase I study of nedaplatin and gemcitabine for advanced non-small-cell lung cancer. (2004)
  • Author(s): Kurata, T., Tamura, K., Yamamoto, N., Nogami, T., Satoh, T., Kaneda, H., Nakagawa, K., Fukuoka, M.
  • Journal Title: Br J Cancer. 90 Pages: 2092-2096
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Retrospective analysis of the predictive factors associated with the response and survival benefit of gefitinib in patients with advanced non-small-cell lung cancer. (2004)
  • Author(s): Kaneda, H., Tamura, K., Kurata, T., Uejima, H., Nakagawa, K., Fukuoka, M.
  • Journal Title: Lung Cancer. 46 Pages: 247-254
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Prediction of sensitivity of advanced non-small cell lung cancers to gefitinib (Iressa, ZD1839). (2004)
  • Author(s): Kakiuchi, S., Daigo, Y., Ishikawa, N., Furukawa, C., Tsunoda, T., Yano, S., Nakagawa, K., Tsuruo, T., Kohno, N., Fukuoka, M., Sone, S., Nakamura, Y.
  • Journal Title: Hum Mol Genet. 13 Pages: 3029-3043
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Interferon-gamma differentially regulates susceptibility of lung cancer cells to telomerase-specific cytotoxic T lymphocytes. (2004)
  • Author(s): Tajima K, Ito Y, Demachi A, Nishida K, Akatsuka Y, Tsujimura K, Hida T, Morishima Y, Kuwano H, Mitsudomi T, Takahashi T, Kuzushima K
  • Journal Title: Int J Cancer. 110(3) Pages: 403-412
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Randomized phase II study of docetaxel/ cisplatin versus docetaxel/ irinotecan in advanced non-small cell lung cancer : a West Japan Thoracic Oncology Study (WJT0G9803). (2004)
  • Author(s): Yamamoto, N., Fukuoka, M., Negoro, S., Nakagawa, K., Saito, H., Matsui, K., Kawahara, M., Senba, H., Ta kada, Y., Kudoh, S., Nakano, T., Katakami, N., Sugiura, T., Hoso, T., Ariyoshi, Y.for the West Japan Thora cic Oncology Group.
  • Journal Title: Br J Cancer. 90 Pages: 87-92
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effect of re-treatment with gefitinib (' Iressa', ZD1839) after acquisition of resistance. (2004)
  • Author(s): Kurata, T., Tamura, K., Kaneda, H., Nogami, T., Uejima, H., Asai, G., Nakagawa, K., Fukuoka, M.
  • Journal Title: Ann Oncol. 15 Pages: 173-174
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Combination phase I study of nedaplatin and gemcitabine for advanced non-small-cell lung cancer (2004)
  • Author(s): Kurata, T., Tamura, K., Yamamoto, N., Nogami, T., Satoh, T., Kaneda, H., Nakagawa, K., Fukuoka, M.
  • Journal Title: Br J Cancer. 90 Pages: 2092-2096
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Interferon-gamma differentially regulates susceptibility of lung cancer cells to telomerase- specific cytotoxic T lymphocytes. Int J Cancer. (2004)
  • Author(s): Tajima K, Ito Y, Demachi A, Nishida K, Akatsuka Y, Tsujimura K, Hida T, Morishima Y, Kuwano H, Mitsudomi T, Takahashi T, Kuzushima K.
  • Journal Title: Jun 20 Pages: 403-12
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Gefitinib-a novel targated approach to treating cance (2004)
  • Author(s): Herbst RS, Fukuoka M, Baselga J.Timeline
  • Journal Title: Nat Rev Cancer 4 Pages: 956-965
• [Journal Article] Retrospective analysis of the predictive factors associated with the response and survival benefit of gefitinib in patients with advanced non-small-cell lung cancer (2004)
  • Author(s): Kaneda, H., Tamura, K., Kurata, T., Uejima, H., Nakagawa, K., Fukuoka, M.
  • Journal Title: Lung Cancer 46 Pages: 247-254
• [Journal Article] Combination phase I study of nedaplatin and gemcitabine for advanced non-small-cell lung cancer (2004)
  • Author(s): Kurata, T., Tamura, K., Yamamoto, N., Nogami, T., Satoh, T., Kaneda, H., Nakagawa, K., Fukuoka, M.
  • Journal Title: Br J Cancer 90 Pages: 2092-2096
• [Journal Article] Effect of re-treatment with gefitinib ('Iressa', ZD1839) after acquisition of resistance (2004)
  • Author(s): Kurata, T., Tamura, K., Kaneda, H., Nogami, T., Uejima, H., Asai, G., Nakagawa, K., Fukuoka, M.
  • Journal Title: Ann Oncol 15 Pages: 173-174
• [Journal Article] Randomized phase II study of docetaxel/ cisplatin versus docetaxel/ irinotecan in advanced non-small cell lung cancer : a West Japan Thoracic Oncology Study (WJTOG98O3) (2004)
  • Author(s): Yamamoto, N., Fukuoka, M., Negoro, S., Nakagawa, K., Saito, H., Matsui, K., Kawahara, M., Senba, H., Takada, Y., Kudoh, S., Nakano, T., Katakami, N., Sugiura, T., Hoso, T., Ariyoshi, Y.for the West Japan Thoracic Oncology Group
  • Journal Title: Br J Cancer 90 Pages: 87-92
• [Journal Article] Prediction of sensitivity of advanced non-small cell lung cancers to gefitinib (Iressa, ZD1839) (2004)
  • Author(s): Kakiuchi, S., Daigo, Y., Ishikawa, N., Furukawa, C., Tsunoda, T., Yano, S., Nakagawa, K., Tsuruo, T., Kohno, N., Fukuoka, M., Sone, S., Nakamura, Y.
  • Journal Title: Hum Mol Genet 13 Pages: 3029-3043