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Roles of the autoantibody against GM-CSF in the pathogenesis, diagnosis, and treatment for idiopathic pulmonary alveolar proteinosis

Research Project

Project/Area Number 16390239
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionNiigata University

Principal Investigator

NAKATA Koh  Niigata University, Medical and dental Hospital, professor, 医歯学総合病院, 教授 (80207802)

Co-Investigator(Kenkyū-buntansha) KEICHO Naoto  International Medical Center of Japan, Department of Respiraymy Diseases, Director, 研究所, 研究部長 (80332386)
NAKAGAKI Kazuhide  Nippon Veterinary and Life Science University, Department of Veterin Medicine, Associate Professor, 獣医学部, 助教授 (90143635)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥14,600,000 (Direct Cost: ¥14,600,000)
Fiscal Year 2005: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2004: ¥11,100,000 (Direct Cost: ¥11,100,000)
Keywordsidiopathic Pulmonary Alveolar Proteinosis / GM-CSF / autoimmune disease GM-CSF / Monoclonal Antibody / Lymphocyte cen surface antigen / 肺胞蛋白症 / 顆粒球マクロファージコロニー刺激因子 / 自己抗体 / アフィニティー / 中和能
Research Abstract

Pulmonary alveolar proteinosis (PAP) is a rare clinical syndrome with currently three recognised forms ; congenital, secondary and acquired. More than 90% of cases are of the latter type, which recently has been characterized as an acquired autoimmune disorder. In PAP excess accumulation of surfactant leads to characteristic bilateral airspace opacities on chest radiograph and extensive alveolar densities with thickened interlobular septa on computed tomography scan. PAP typically appears in previously healthy individuals, who present with several months of dyspnoea and impaired pulmonary gas transfer of variable severity. "Milky" appearing, lipid-rich fluid recovered at bronchoalveolar lavage is characteristic, while lung biopsy, when performed, shows minimally inflamed alveoli uniformly filled with amorphous eosinophilic material that on electron microscopy contains characteristic lamellar bodies. Current concepts of pathogenesis in acquired PAP are that the excess surfactant results from impaired clearance by alveolar macrophages, as a result of inhibition by specific polyclonal autoantibodies of trophic physiological signals from the endogenous cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF). Current therapy consists of whole-lung lavage under general anesthesia, repeated as needed by clinical status, while some adult patients also respond to the repeated administration of recombinant human GM-CSF.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (20 results)

All 2006 2005 2004 Other

All Journal Article (19 results) Book (1 results)

  • [Journal Article] Pulmonary alveolar Protein sis.2006

    • Author(s)
      Seymour JF
    • Journal Title

      Encycropedia of Respiratory Medicine (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Why does the autoantibody against GM-CSF cause lesions only in the lung?2006

    • Author(s)
      Nakata K.
    • Journal Title

      Respirology 11

      Pages: 65-69

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Outbreak of Nocardia farcinica infection with the same pattern in randomly amplified pormorphic DNA analysis2006

    • Author(s)
      S.Kachi
    • Journal Title

      Journal of Hospital Infection (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Successful treatment of congenital pulmonary alveolar protein sis with intravenous immunoglobulin G administration.2006

    • Author(s)
      Cho k
    • Journal Title

      Respirology 11

      Pages: 74-77

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Why does the autoantibody against GM-CSF cause lesions only in the lung?2006

    • Author(s)
      Nakata K.Kanazawa H, Watanabe M.
    • Journal Title

      Respirology (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Pulmonary alveolar Proteinosis.2006

    • Author(s)
      Seymour JF
    • Journal Title

      Encycropedia of Respiratory Medicine (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Why does the autoantibody against GM-CSF cause lesions only in the lung?2006

    • Author(s)
      Nakata K
    • Journal Title

      Respirology 11

      Pages: 65-69

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Successful treatment of congenital pulmonary alveolar proteinosis with intravenous immunoglobulin G administration.2006

    • Author(s)
      Cho k
    • Journal Title

      Respirology 11

      Pages: 74-77

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Granulocyte-macrophage Colony Stimulating Factor and Lung Immunity in Pulmonary Alveolar Protein sis.2005

    • Author(s)
      Tazawa R
    • Journal Title

      Am J Respir Grit Care Med. 171

      Pages: 1142-1149

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] DNA sequence diversity of intergenic spacer I region. in the non-lipid-dependent species Malassezia pachydermatis isolated from animals.2005

    • Author(s)
      Sugita T
    • Journal Title

      Medical Mycology 43・1

      Pages: 21-26

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Granulocyte-macrophage Colony Stimulating Factor and Lung Immunity in Pulmonary Alveolar Proteinosis.2005

    • Author(s)
      Tazawa R, Hamano E, Nakata K(corresponding author), Nukiwa T.
    • Journal Title

      Am J Respir Crit Care Med. 25

      Pages: 1142-1149

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Granulocyte-macrophage Colony Stimulating Factor and Lung Immunity in Pulmonary Alveolar Proteinosis.2005

    • Author(s)
      Tazawa R
    • Journal Title

      Am J Respir Crit Care Med. 171

      Pages: 1142-1149

    • Related Report
      2005 Annual Research Report
  • [Journal Article] DNA sequence diversity of intergenic spacer I region in the non-lipid-dependent species Malassezia pachydermatis isolated from animals.2005

    • Author(s)
      Sugita T
    • Journal Title

      Medical Mycology 43・1

      Pages: 21-26

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Pulmonary alveolar proteinosis. Clin2004

    • Author(s)
      Presneill JJ
    • Journal Title

      Chest Med 25・3

      Pages: 593-613

    • Related Report
      2004 Annual Research Report
  • [Journal Article] BCL-6 mutations in pulmonary lymphoproliferative disorders : demonstration of an aberrant Immunological in HIV-related lymphoid interstitial pneumonia2004

    • Author(s)
      Kurosu K
    • Journal Title

      J Imunol 1;172・11

      Pages: 7116-7122

    • Related Report
      2004 Annual Research Report
  • [Journal Article] High-affinity autoantibodies specifically eliminate granulocyte-macrophage colony-stimulating factor activity in the lungs of patients with idiopathic pulmonary alveolar proteinosis2004

    • Author(s)
      Uchida K
    • Journal Title

      Blood 1;103・3

      Pages: 1089-1098

    • Related Report
      2004 Annual Research Report
  • [Journal Article] A case of idiopathic pulmonary alveolar proteinosis accompanied by T-cell receptor gene rearrangement in bronchoalveolar lavage fluid cells2004

    • Author(s)
      Hosokawa T
    • Journal Title

      Respirology 9・2

      Pages: 286-288

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Serum neutralizing capacity of GM-CSF reflects disease severity in a patient with pulmonary alveolar proteinosis successfully treated with inhaled GM-CSF2004

    • Author(s)
      Arai T
    • Journal Title

      Respir Med 98・12

      Pages: 1227-1230

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Granulocyte-macrophage colony stimulating factor and lung immunity in pulmonary alveolar proteinosis

    • Author(s)
      Ryushi Tazawa
    • Journal Title

      Am.J.Respir.Crit.Care.Med (in press)

    • Related Report
      2004 Annual Research Report
  • [Book] 臨床に直結する呼吸器疾患治療のエビデンス2005

    • Author(s)
      寺田正樹, 中田 光
    • Total Pages
      255
    • Publisher
      文光堂
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary

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Published: 2004-04-01   Modified: 2021-12-20  

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