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Research on the diagnosis of Periventricular Leukomalacia (PVL) by ECHO second harmonic imaging in preterm infants

Research Project

Project/Area Number 16390311
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Embryonic/Neonatal medicine
Research InstitutionNagoya City University

Principal Investigator

TOGARI Hajime  Nagoya City University, Graduate School of Medical Sciences, Professor, 大学院医学研究科, 教授 (50106233)

Co-Investigator(Kenkyū-buntansha) FUJIMOTO Shinji  Nagoya City University, Graduate School of Medical Sciences, Associate Professor, 大学院医学研究科, 助教授 (60238615)
FUKUDA Sumio  Nagoya City University, Graduate School of Medical Sciences, Research Associate, 大学院医学研究科, 助手 (90336678)
FURUHATA Hiroshi  The Jikei University School of Medicine, Professor, 医学部, 教授 (70056985)
Project Period (FY) 2004 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥14,400,000 (Direct Cost: ¥14,400,000)
Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2005: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2004: ¥10,800,000 (Direct Cost: ¥10,800,000)
KeywordsPeriventricular Leukomalacia / Ultrasonography / Neonate / 超音波診断
Research Abstract

Most important issue in current neonatal medicine is the prevention of neurological complication especially cerebral palsy, mental retardation and learning disorders. However, it is well known that 5 to 15 % of preterm infants born under 32 weeks of gestation develop neurological complication and 80 % of cerebral palsy is recognized as the result of PVL. According to the surveillance analysis all over the Japan, the incidence of PVL does not change for many years in this country.
Second harmonics imaging technique by ECHO which we are presently trying to widely use in the neonatal clinical is simple, bed-side operating, and sensitive for the detection of fine capillary blood flow. This technique has been used in liver and heart blood flow detection together with the usage in adult neurology field.
We have succeeded in the detection of blood flow in all cased performed by this Second harmonic imaging technique. Examination time was extremely short compared to MRI and CT. It was safe enough to perform it at the bed side and did not require to move the patient nor to give the sedatives to the patient.
PVL patient with LCD (Late onset cardiac dysfunction) episode had severer neurological outcome from the MRI findings. In sepsis, there is a close correlation between oxidative stress and inflammatory or anti-inflammatory
cytokines.

Report

(4 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (15 results)

All 2006 2005 2004

All Journal Article (15 results)

  • [Journal Article] Total Hydroperoxide and Biological Antioxidant Potentials in a Neonatal Sepsis Model2006

    • Author(s)
      Hiroki Kakita, et al.
    • Journal Title

      Pediatric Research Vol.60, No.6

      Pages: 675-679

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Periventricular Leukomalacia with Late-Oncet Circulatory Dysfunction of Peremature Infants : Correlation with Severy of Magnetic Resonance Imaging Findings and Neurological Outcomes2006

    • Author(s)
      Satoru Kobayashi, et al.
    • Journal Title

      Tohoku J. Exp. Med. 210

      Pages: 333-339

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Hemodynamics of the Cerebral Arteries of Infants with Periventricular Leukomalacia2006

    • Author(s)
      Fukuda S, et al.
    • Journal Title

      Pediatrics 117(1)

      Pages: 1-8

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Periventricular Leukomalacia with Late-Onset Circulatory Dysfunction of Premature Infants : Correlation with Severity of Magnetic Resonance Imaging Findings and Neurological Outcomes2006

    • Author(s)
      Kobayashi S, Fujimoto S, Fukuda S, Hattori A, Iwaki T, Koyama N, Tanaka T, Kokubo M, Okanishi T, Togari H.
    • Journal Title

      Tohoku J Exp Med. 210(4)

      Pages: 333-9

    • NAID

      10018809915

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Total Hydroperoxide and Biological Antioxidant Potentials in a Neonatal Sepsis Model2006

    • Author(s)
      Kakita H, Hussein MH, Daoud GA, Kato T, Murai H, Sugiura T, Mizuno K, Yamada Y, Ito T, Fukuda S, Kato I, Suzuki S, Togari H.
    • Journal Title

      Pediatr Res. 60(6)

      Pages: 675-9

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Hemodynamics of the Cerebral Arteries of Infants with Periventricular Leukomalacia2006

    • Author(s)
      Fukuda S, Kato T, Kakita H, Yamada Y, Hussein MH, Kato I, Suzuki S, Togari H.
    • Journal Title

      Pediatrics. 117(1)

      Pages: 1-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Hemodynamics of the Cerebral Arteries of Infants With Periventricular Leukomalacia2006

    • Author(s)
      Fukuda S
    • Journal Title

      Pediatrics 117(1)

      Pages: 212-213

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effect of Hemoperfusion Using Polymyxin B-Immobilized Fiber on IL-6, HMGB-1, and IFN Gamma in a Neonatal Sepsis Model2005

    • Author(s)
      Hussein MH, et al.
    • Journal Title

      Pediatr Res. 58(2)

      Pages: 309-314

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Hemodynamics of the Posterior Cerebral Arteries in Neonates with Periventricular Leukomalacia2005

    • Author(s)
      Fukuda S, et al.
    • Journal Title

      J Clin Ultrasound. 33(1)

      Pages: 24-28

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The Ratio of Flow Velocities in the Middle Cerebral and Internal Carotid Arteries for the Prediction of Cerebral Palsy in Term Neonates2005

    • Author(s)
      Fukuda S, et al.
    • Journal Title

      J Ultrasound Med. 24(2)

      Pages: 149-153

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effect of Hemoperfusion Using Polymyxin B-Immobilized Fiber on IL-6, HMGB-1, and IFN Gamma in a Neonatal Sepsis Model2005

    • Author(s)
      Hussein MH, Kato T, Sugiura T, Daoud GA, Suzuki S, Fukuda S, Sobajima H, Kato I, Togari H.
    • Journal Title

      Pediatr Res. 58(2)

      Pages: 309-14

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Hemodynamics of the Posterior Cerebral Arteries in Neonates with Periventricular Leukomalacia2005

    • Author(s)
      Fukuda S, Kuwabara S, Yasuda M, Mizuno K, Kato T, Sugiura T, Hussein MH, Kato I, Fujimoto S, Sobajima H, Togari H.
    • Journal Title

      J Clin Ultrasound. 33(1)

      Pages: 24-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The Ratio of Flow Velocities in the Middle Cerebral and Internal Carotid Arteries for the Prediction of Cerebral Palsy in Term Neonates2005

    • Author(s)
      Fukuda S, Kato T, Kuwabara S, Kato I, Futamura M, Togari H.
    • Journal Title

      J Ultrasound Med. 24(2)

      Pages: 149-53

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 特集 新生児の理学、生理学的評価法-基準とその異常-脳血行動態評価2005

    • Author(s)
      福田純男
    • Journal Title

      周産期医学 35(11)

      Pages: 1475-1479

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Hemodynamics of the posterior cerebral arteries in neonates with perivetricular leukomalacia2004

    • Author(s)
      Fukuda S, 他
    • Journal Title

      J.Clin.Ultrasound 33(1)

      Pages: 24-28

    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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