| Project/Area Number |
16390322
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Psychiatric science
|
|---|
| Research Institution | Hamamatsu University School of Medicine |
|---|
Principal Investigator |
TAKEI Norigoshi Hamamatsu U Sch Med, Psychiatry, Associate Professor, 医学部, 助教授 (80206937)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KAWAI Masayoshi Hamamatsu U Sch Med, Psychiatry, Assistant, 医学部, 助手 (30283352)
MORI Norio Hamamatsu U Sch Med, Psychiatry, Professor, 医学部, 教授 (00174376)
ISODA Haruo Hamamatsu U Sch Med, Radiology, Associate Professor, 医学部, 助教授 (40223060)
SAKAHARA Harumi Hamamatsu U Sch Med, Radiology, Professor, 医学部, 教授 (10187031)
NAKAMURA Kazuhiko Hamamatsu U Sch Med, Psychiatry, Lecturer, 医学部附属病院, 講師 (80263911)
|
|---|
| Project Period (FY) |
2004 – 2005
|
| Project Status |
Completed (Fiscal Year 2005)
|
| Budget Amount *help |
¥12,200,000 (Direct Cost: ¥12,200,000)
Fiscal Year 2005: ¥4,600,000 (Direct Cost: ¥4,600,000)
Fiscal Year 2004: ¥7,600,000 (Direct Cost: ¥7,600,000)
|
|---|
| Keywords | Schizophrenia / MRS / High risk / Phenotype / 表現型 / 遺伝 / high risk / 脳形態学 / MRI / 海馬 / 神経心理学検査 / WAIS |
|---|
| Research Abstract |
Schizophrenia is considered to be a neurobiological disorder and have a genetic liability. The examination of relatives of subjects with schizophrenia is one approach to detect the fundamental neurobiological characteristics more directly linked to gene expression.
In this study, we assessed neurochemical indices, using ^1H-MRS, in the left dorsolateral prefrontal, anterior cingulate, left hippocampus, and left striatum in the offspring (n=6) of parents with schizophrenia (‘high risk' (HR) individuals) and in healthy controls (HC) (n=4). We also evaluated cognitive performance in each individual of the subjects with Wechsler Adult Intelligence Scale revised (WAIS-R), Wechsler Memory Scales revised (WMS-R) and the Cambridge Automated Neuropsychological Test Battery (CANTAB).
Although HR subjects had relatively lower NAA in all of the 4 regions studied compared with HC subjects, these differences did not reach the conventional level of statistical significance. In the left DLPFC, the Cho level was significantly lower in the HR group (mean±s.d.;3.0±0.42) than in the HC group (4.1±0.32) (p=0.003). As for the neuropsychological tests, HR subjects had impaired performance, at a trend level, on spatial working memory task and Stroop test, compared to HC subjects.
Our finding of comparatively low Cho level in the left DLPFC in the HR subjects may suggest that membrane "turnover" is suppressed in HR subjects in some areas of the brain, especially in the left DLPFC. However, this is a preliminary study. To confirm the findings, we will recruit more subjects and continue to obtain data with which to explore the relationships between brain metabolite alterations related to genetic predisposition to schizophrenia and cognitive functions.
|
