| Project/Area Number |
16390332
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Tohoku University |
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Principal Investigator |
IWATA Reni Tohoku University, Cyclotron and Radioisotope Center, Professor, サイクロトロン・ラジオアイソトープセンター, 教授 (60143038)
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| Co-Investigator(Kenkyū-buntansha) |
YANAI Kazuhiko Tohoku University, Graduate School of Medicine, Professor, 大学院医学系研究科, 教授 (50192787)
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| Project Period (FY) |
2004 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥13,600,000 (Direct Cost: ¥13,600,000)
Fiscal Year 2006: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2005: ¥6,200,000 (Direct Cost: ¥6,200,000)
Fiscal Year 2004: ¥4,700,000 (Direct Cost: ¥4,700,000)
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| Keywords | PET / F-18 / radiopharmaceutical / Molecular probe / Automated synthesis / Fluoromethyl |
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| Research Abstract |
The objectives of this research project was to prepare a variety of 18F-labeled compounds using [^<18>F]fluoromethyl bromide or [^<18>F]fluoromethyl triflate and evaluate their usefulness in PET diagnosis. The main subjects were (1)automated synthesis of [^<18>F]fluoromethyl triflate, (2)synthetic use in the preparation of ^<18>F-labeled radiopharmaceuticals, (3)development of automated module for preparation of [^<18>F]fluorocholine, and (4)biological/clinical evaluation of [^<18>F]fluoromethyltyrosine.
1.An automated miniature module for the preparation of [^<18>F]fluoromethyl bromide from [^<18>F]fluoride was successfully developed using the original manifold technology.
2.[^<18>F]Fluoromethylation was carried out on various compounds using [^<18>F]fluoromethyl triflate. It was found, however, that they were all unstable except for [^<18>F]fluorocholine and [^<18>F]fluoromethyltyrosine.
3.An automated miniature module was also developed for the preparation of [^<18>F]fluorocholine using [^<18>F]fluoromethyl triflate.
4.[^<18>F]Fluoromethyltyrosine was evaluated to image tumors and to distinguish them from inflammation. It was shown that [^<18>F]fluoromethyltyrosine was as good a candidate as [^<18>F]fluoromethyltyrosine for imaging tumors.
In conclusion, the usefulness of [^<18>F]fluoromethyl triflate for [^<18>F]Fluoromethylation in convenient preparation of ^<18>F-labeled radiopharmaceuticals was investigated and the results were obtained that many [^<18>F]fluoromethylated compounds were not stable and only [^<18>F]fluorocholine and [^<18>F]fluoromethyltyrosine were stably prepared. They were prepared with the dedicated automated modules and used in basic studies for their evaluation as tumor imaging agents.
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