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Development of high sensitivity, light-weight portable gamma camera based on innovative fundamentals for nuclear medicine examinations

Research Project

Project/Area Number 16390343
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionKeio University

Principal Investigator

KUBO Atushi  Keio University, School of Medicine, Professor, 医学部, 教授 (90051771)

Co-Investigator(Kenkyū-buntansha) KUNIEDA Etsuo  Keio University, School of Medicine, Associate Professor, 医学部, 講師 (70170008)
NAKAHARA Tadaki  Keio University, School of Medicine, Assistant Professor, 医学部, 助手 (10317240)
TANIMORI Toru  Kyoto University, Graduate School of Science, Professor, 大学院・理学研究科, 教授 (10179856)
OGAWA Koichi  Hosei University, Faculty of Engineering, Professor, 工学部, 教授 (00158817)
MIUCHI Kentaro  Kyoto University, Graduate School of Science, Assistant Professor, 大学院・理学研究科, 助手 (80362440)
Project Period (FY) 2004 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥14,300,000 (Direct Cost: ¥14,300,000)
Fiscal Year 2006: ¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2005: ¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2004: ¥7,300,000 (Direct Cost: ¥7,300,000)
Keywordsgamma-ray / Compton Camera / nuclear medicine / isotope / 放射線 / コンプトン効果 / 可搬型ガンマカメラ / 超高感度 / 超軽量 / コンプトン散乱 / 検出器
Research Abstract

The Compton Camera which can directly detect the incident direction of gamma-ray does not need the collimator in principle. This camera is very efficient and high sensitive because it can utilize the information of gamma-ray from various directions.
We applied Compton effects for nuclear medicine field and developed a new-type gamma camera which omits the shielding around the collimator and detector. We have realized both full ray-tracing and the background rejection for MeV and sub-MeV gamma-ray imaging by detecting the direction of the scatted electron in Compton process.
The Compton camera is consisted of two detectors. Incident gamma-ray is scattered in the first (scatter) detector by Compton scattering. This detector takes the recoil electron energy. Our system utilizes a gas chamber as the first detector and the track of the recoil electron was detected with a flat detector placed on the edge of the gas chamber. The scattered gamma-ray is stopped in the second (absorb) detector. The second detector takes the energy and position of scattered gamma-ray. Using above energy and position information, the Compton gamma-ray camera is able to reconstruct the incident gamma-ray direction as cylindrical direction. What is important is that this system does not need the collimator. It enables the wide energy dynamic range and wide FOV.

Report

(4 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (33 results)

All 2006 2005 2004

All Journal Article (33 results)

  • [Journal Article] Value of CT thallium-201 SPECT fusion imaging over SPECT alone for detection and localization of nasopharyngeal and maxillary cancers.2006

    • Author(s)
      Nakahara T, Shigematsu N, Fujii M, Kunieda E, Suzuki T, Kubo, A. et al.
    • Journal Title

      AJR Am J Roentgenol. 187(3)

      Pages: 825-829

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Rotational and translational reproducibility of newly developed Leksell frame-based relocatable fixation system2006

    • Author(s)
      Kunieda E, Deloar HM, Kitamura M, Kawaguchi O, Shiba H, Kubo, A. et al.
    • Journal Title

      Radiat Med. 24(7)

      Pages: 503-510

    • NAID

      10018257173

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Value of CT thallium-201 SPECT fusion imaging over SPECT alone for detection and localization of nasopharyngeal and maxillary cancers.2006

    • Author(s)
      Nakahara T, Shigematsu N, Fujii M, Kunieda E, Suzuki T, Tanaka C, Hashimoto J, Kubo A
    • Journal Title

      AJR Am J Roentgenol 187(3)

      Pages: 825-829

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Rotational and translational reproducibility of newly developed Leksell frame-based relocatable fixation system Radial Med. 24(7) : 503-10. 20062006

    • Author(s)
      Kunieda E, Deloar HM, Kitamura M, Kawaguchi 0, Shiba H, Takeda A, Kawase T, Seki S, Shigematsu N, Kubo A
    • Journal Title

      Radial Med 24(7)

      Pages: 503-510

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 【婦人科疾患の画像診断】 卵巣癌に対するPET検査2006

    • Author(s)
      藤井博史, 井出満, 安田聖栄, 村上優, 村上康二, 久保敦司
    • Journal Title

      産婦人科治療 92巻1号

      Pages: 57-62

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Influence of ageing on perioperative cardiac risk in non-cardiac surgery Ageing and perioperative cardiac risk.2006

    • Author(s)
      Bai J, Hashimoto J, Nakahara T, Suzuki T, Kubo A
    • Journal Title

      Age Ageing (in printing)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Repair of Potentially Lethal Damage in Normal Cells and Ataxia Telangiectasia Cells; Consideration of Non-Homologous End-Joining.2006

    • Author(s)
      Kan'o M, Kawata T, Ito H, Shigematsu N, Liu C, Uno T, Isobe K, Kawakami H, Cucinotta F, George K, Kubo A
    • Journal Title

      J Radiat Res in printing

    • NAID

      110006570514

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Rotational and translational reproducibility of newly developed Leksell frame-based relocatable fixation system.2006

    • Author(s)
      Kunieda E, Deloar HM, Kitamura M, Kawaguchi O, Shiba H, Takeda A, Kawase T, Seki S, Shigematsu N, Kubo A
    • Journal Title

      Radiat Med. 24(7)

      Pages: 503-10

    • NAID

      10018257173

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Influence of two transfectors on delivery of 99mTc antisense DNA in tumor-bearing mice.2006

    • Author(s)
      Nakamura K, Wang Y, Liu X, Kubo A, Hnatowich DJ
    • Journal Title

      Mol Imaging Biol. 8(3)

      Pages: 182-92

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Credentialing of nuclear medicine physicians, surgeons, and pathologists as a multidisciplinary team for selective sentinel lymphadenectomy2005

    • Author(s)
      Masaki Kitajima, Yuko Kitagawa, Hirofumi Fujii, Atsushi Kubo et al.
    • Journal Title

      Selective sentinel lymphadenectomy for human solid cancer. 127

      Pages: 253-267

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Development of an advanced Compton camera with gaseous TPC and scintillator2005

    • Author(s)
      A.Takada, K.Hattori, H.Kubo, K.Miuchi, T.Nagayoshi, H.et al.
    • Journal Title

      Nuclear Instruments and Methods in Physics Research Section A : Accelerators, Spectrometers, Detectors and Associated Equipment 546(1-2)

      Pages: 258-262

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Credentialing of nuclear medicine physicians, surgeons, and pathologists as a multidisciplinary team for selective sentinel lymphadenectomy2005

    • Author(s)
      Masaki Kitajima, Yuko Kitagawa, Hirofumi Fujii, Makio Mukai, Atsushi Kubo
    • Journal Title

      Selective sentinel lymphadenectomy for human solid cancer 127

      Pages: 253-267

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Development of an advanced Compton camera with gaseous TPC and scintillator2005

    • Author(s)
      A.Takada, K.Hattori, H.Kubo, K.Miuchi, T.Nagayoshi, H.Nishimura, Y.Okada, R.Orito, H.Sekiya
    • Journal Title

      Nuclear Instruments and Methods in Physics Research Section A : Accelerators, Spectrometers, Detectors and Associated Equipment Volume 546, Issues 1-2

      Pages: 258-262

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Simulation study of electron drift and gas multiplication in Micro Pixel Chamber2005

    • Author(s)
      T.Nagayoshi, T.Tanimori, et al.
    • Journal Title

      Nuclear Instruments and Methods in Physics Research Sect.A 546

      Pages: 457-465

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Development of an advanced Compton camera with gaseous TPC and scintillator2005

    • Author(s)
      A.Takada, T.Tanimori, et al.
    • Journal Title

      Nuclear Instruments and Methods in Physics Research Sect.A 546

      Pages: 258-262

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Speedy and accurate voxel searching method with a source space tree (SSTA) algorithm in Compton camera,2005

    • Author(s)
      T.Kurihara, K.Ogawa
    • Journal Title

      Japanese Journal of Medical Physics Supp.3-1

      Pages: 138-141

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The performance of data acquisition scheme in a new myocardial SPECT system2004

    • Author(s)
      N.Kobayashi, K.Ogawa, N.Motomura, H.Fujii, A.Kubo
    • Journal Title

      Medical Imaging Technology 22(2)

      Pages: 85-91

    • NAID

      10012867929

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Quantification of I-123 and Tc-99m in dual-isotope SPECT with an artificial neural network2004

    • Author(s)
      M.Ishii, K.Ogawa, T.Nakahara, J.Hashimoto, A.Kubo
    • Journal Title

      Medical Imaging Technology 122(3)

      Pages: 155-163

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The performance of data acquisition scheme in a new myocardial SPECT system2004

    • Author(s)
      N.Kobayashi, K.Ogawa, N.Motomura, H.Fujii, A.Kubo
    • Journal Title

      Medical Imaging Technology vol.22, No.2

      Pages: 85-91

    • NAID

      10012867929

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Quantification of 1-123 and Tc-99m in dual-isotope SPECT with an artificial neural network2004

    • Author(s)
      M.Ishii, K.Ogawa, T.Nakahara, J.Hashimoto, A.Kubo
    • Journal Title

      Medical Imaging Technology vol.22, No.3

      Pages: 155-163

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Performance and applications of a micro-TPC2004

    • Author(s)
      K.Miuchi, T.Tanimori 他
    • Journal Title

      Nuclear Instruments and Methods in Physics Research A 535

      Pages: 236-241

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Time projection chamber based on micro-pattern detector for neutron time-resolved imaging2004

    • Author(s)
      T.Tanimori 他
    • Journal Title

      Nuclear Instruments and Methods in Physics Research A 529

      Pages: 373-377

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Development of an MeV gamma-ray imaging detector2004

    • Author(s)
      A.Takeda, T.Tanimori 他
    • Journal Title

      IEEE Transactions on Nuclear Science 51巻4号

      Pages: 2140-2144

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Development of an ASD IC for the Micro Pixel Chamber2004

    • Author(s)
      R.Orito, T.Tanimori 他
    • Journal Title

      IEEE Transactions on Nuclear Science 51巻4号

      Pages: 1337-1342

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Compton gamma-ray imaging detector with electron tracking2004

    • Author(s)
      R.Orito, T.Tanimori 他
    • Journal Title

      Nuclear Instruments and Methods in Physics Research A 525

      Pages: 107-113

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Development of μ-PIC and its imaging properties2004

    • Author(s)
      T.Nagayoshi, T.Tanimori 他
    • Journal Title

      Nuclear Instruments and Methods in Physics Research A 525

      Pages: 20-27

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Performance of the micro-TPC for the time-resolved neutron PSD2004

    • Author(s)
      K.Miuchi, T.Tanimori 他
    • Journal Title

      Nuclear Instruments and Methods in Physics Research A 517

      Pages: 219-225

    • Related Report
      2004 Annual Research Report
  • [Journal Article] MeV Gamma-Ray Imaging Detector with micro-TPC2004

    • Author(s)
      Toru Tanimori 他
    • Journal Title

      New Astronomy Reviews 48

      Pages: 263-268

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 微細加工技術を用いたガス・マイクロパターン検出器μ-PICの開発とその応用2004

    • Author(s)
      永吉 勉, 身内 賢太朗, 窪 秀利, 谷森 達
    • Journal Title

      高エネルギーニュース 第23巻1号

      Pages: 1-6

    • Related Report
      2004 Annual Research Report
  • [Journal Article] AVM radiosurgery治療計画における動脈造影dynamic CTの意義2004

    • Author(s)
      川口修, 国枝悦夫, 久保敦司
    • Journal Title

      定位的放射線治療 12・1

      Pages: 71-79

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Radiation Injury after Hypofractionated Stereotactic Radiotherapy for Peripheral Small Lung Tumors : Serial Changes on Computed Tomography2004

    • Author(s)
      T.Takeda, A.Takeda, E.Kunieda, A.Kubo
    • Journal Title

      American Journal of Rentogenology 182(5)

      Pages: 1123-1128

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Evaluation of novel modified tangential irradiation technique for breast cancer patients using dose-volume histograms.2004

    • Author(s)
      A.Takeda, E.Kunieda, A._Kubo
    • Journal Title

      Int J Radiat Oncol Biol Phys. 58(4)

      Pages: 1280-1288

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Measurement of beam-axis displacement from the isocenter during three-dimensional conformal radiosurgery with a micro-multileaf collimator2004

    • Author(s)
      E.Kunieda, O.Kawaguchi, H., A.Kubo
    • Journal Title

      Radiotherapy and Oncology 70(1)

      Pages: 45-48

    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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