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Oncolytic Viral Therapy Using Mutant Herpes Simplex Virus (HF10) for Cancer

Research Project

Project/Area Number 16390358
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionNagoya University

Principal Investigator

AKIMASA Nakao  Nagoya University, Graduate School of Medicine, Professor, 大学院医学系研究科, 教授 (70167542)

Co-Investigator(Kenkyū-buntansha) KODERA Yasuhiro  Nagoya University, Graduate School of Medicine, Assistant Professor, 大学院医学系研究科, 講師 (10345879)
TAKEDA Shin  Nagoya University, Graduate School of Medicine, Assistant Professor, 大学院医学系研究科, 講師 (20314015)
NISHIYAMA Yukihiro  Nagoya University, Graduate School of Medicine, Professor, 大学院医学系研究科, 教授 (60115615)
KASUYA Hideki  Nagoya University, School of Medicine, Assistant Professor, 医学部, 非常勤講師 (00402636)
Project Period (FY) 2004 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥12,100,000 (Direct Cost: ¥12,100,000)
Fiscal Year 2006: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 2005: ¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2004: ¥6,400,000 (Direct Cost: ¥6,400,000)
KeywordsOncolytic virus / Herpes virus / HF10 / Translational research / Pancreatic cancer / Gene therapy / Disseminated peritoneal / Breast cancer / ウイルス療法 / 抗腫瘍効果
Research Abstract

1. A pilot study using oncolytic herpes virus (HF 10) was initiated, preliminary to proceeding further research projects, in six patients with recurrent breast cancer. On the basis of the result from this pilot study, we have accumulated basic research data and clinical data for oncolytic virus therapy regarding safety and effectiveness.
2. We have conducted a clinical trial for three patients with non-resectable pancreatic cancer under the approval of the Nagoya University School of Medicine. The intraoperative injection of HF10 into pancreatic tumor cell was performed with laparotomy. We assessed laboratory data of the trial, including white blood cell count, natural killer cells, IL12 and IFN. We observed no adverse effects in all patients, and kept monitoring their progress.
3. We have launched new fundamental experiment regarding peritoneal injection of HF 10. We have accumulated basic date of survival rate and side effect using peritoneal disseminated cancer tumor mice model. We have also accumulated the data about host immune response against oncolytic virus. Anti virus antibody positive serum strongly inhibited virus activity.
4. We studied about combination therapy of oncolytic virus (HF10) and chemotherapy drug in vitro and in vivo. Combination therapy of oncolytic virus and chemotherapy drug enhanced tumor-killing effect than single use.
5. For the drug approval in future, we have completed a production process of GMP standard purified oncolytic virus (HF 10) in England.

Report

(4 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (44 results)

All 2007 2006 2005 2004 Other

All Journal Article (42 results) Book (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Clinical experiment of mutant herpes simplex virus HF10 therapy for cancer2007

    • Author(s)
      Nakao A, Takeda S, Shimoyama S, Kasuya H, et al.
    • Journal Title

      Current Cancer Drag Targets 7・2

      Pages: 169-174

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Oncolytic virus therapy-foreword2007

    • Author(s)
      Kasuya H, Takeda S, Shimoyama S, Shikano N, Nomura N, et al.
    • Journal Title

      Current Cancer Drag Targets 7・2

      Pages: 123-125

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Suitability of a US3-inactivated HSV mutant (L1BR1) as oncolytic virus for pancreatic cancer therapy2007

    • Author(s)
      Kasuya H, Nishiyama Y, Nomoto S, Goshima F, Takeda S, et al.
    • Journal Title

      Cancer Gene Therapy accepted

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Enhanced efficacy of herpes simplex virus mutant HF10 combined with paclitaxel in peritoneal cancer dissemination models2007

    • Author(s)
      Shimoyama S, Goshima F, Teshigahara O, Kasuya H, et al.
    • Journal Title

      Hepatogastroenterology accepted

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Clinical experiment of mutant herpes simplex virus HF10 therapy for cancer.2007

    • Author(s)
      Nakao A, Takeda S, Shimoyama S, Kasuya H, et al.
    • Journal Title

      Current Cancer Drag Targets 7-2

      Pages: 169-174

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Oncolytic virus therapy-foreword.2007

    • Author(s)
      Kasuya H, Takeda S, Shimoyama S, Shikano N, Nomura N, et al.
    • Journal Title

      Current Cancer Drag Targets 7-2

      Pages: 123-125

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Suitability of a US3-inactivated HSV mutant (L1BR1) as oncolytic virus for pancreatic cancer therapy.2007

    • Author(s)
      Kasuya H, Nishiyama Y, Nomoto S, Goshima F, Takeda S, et al.
    • Journal Title

      Cancer Gene Therapy (accepted)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Enhanced efficacy of herpes simplex virus mutant HF10 combined with paclitaxel in peritoneal cancer dissemination models.2007

    • Author(s)
      Shimoyama S, Goshima F, Teshigahara O, Kasuya H, et al.
    • Journal Title

      Hepatogastroenterology (accepted)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Suitability of a US3-inactivated HSV mutant (L1BR1) as oncolytic virus for pancreatic cancer therapy2007

    • Author(s)
      Kasuya H, Nishiyama Y, Nomoto S, Goshima F, Takeda S, et al.
    • Journal Title

      Cancer Gene Therapy (accepted)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Enhanced efficacy of herpes simplex virus mutant HF10 combined with paclitaxel in peritoneal cancer dissemination models2007

    • Author(s)
      Shimoyama S, Goshima F, Teshigahara O, Kasuya H, et al.
    • Journal Title

      Hepatogastroenterology (accepted)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Pilot study of oncolytic viral therapy using mutant herpes simplex virus (HF10) against recurrent metastatic breast cancer2006

    • Author(s)
      Kimata H, Imai T, Kikumori T, Teshigahara O, et al.
    • Journal Title

      Annals of Surgical Oncology 13・8

      Pages: 1078-1084

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] 増殖型HSVの癌治療への臨床応用2006

    • Author(s)
      粕谷英樹, 中尾昭公
    • Journal Title

      日本臨牀 64・3

      Pages: 335-339

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 癌に対するウイルス療法2006

    • Author(s)
      下山理史, 中尾昭公
    • Journal Title

      日本臨牀 64・3

      Pages: 589-596

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] ヘルペスウイルス研究の歴史2006

    • Author(s)
      西山幸廣
    • Journal Title

      日本臨牀 64・3

      Pages: 7-12

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Pilot study of oncolytic viral therapy using mutant herpes simplex virus (HF10) against recurrent metastatic breast cancer.2006

    • Author(s)
      Kimata H, Imai T, Kikumori T, Teshigahara O, et al.
    • Journal Title

      Annals of Surgical Oncology 13-8

      Pages: 1078-1084

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Clinical application of replication competent mutant HSV in cancer therapy.2006

    • Author(s)
      Kasuya H, Nakao A.
    • Journal Title

      Nippon Rinsho 64 Suppl-3

      Pages: 335-339

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Nakao A. Oncolytic viral therapy for cancer therapy.2006

    • Author(s)
      Shimoyama S
    • Journal Title

      Nippon Rinsho 64-3

      Pages: 589-596

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] History of herpesvirus research.2006

    • Author(s)
      Nishiyama Y.
    • Journal Title

      Nippon Rinsho 64-3, Suppl-3

      Pages: 7-12

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 癌に対するウイルス療法2006

    • Author(s)
      下山理史, 沖尾昭公
    • Journal Title

      日本臨牀 64・3

      Pages: 589-596

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The potential of oncolytic virus therapy for pancreatic cancer2005

    • Author(s)
      Kasuya H, Takeda S, Nomoto S, Nakao A
    • Journal Title

      Cancer Gene Therapy 12・9

      Pages: 725-736

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Mouse models of subcutaneous spleen reservoir for multiple portal venous injections to treat liver maligancies2005

    • Author(s)
      Kasuya H, Kuruppu DK, Donahue JM, Choi EW, Kawasaki H, et al.
    • Journal Title

      Cancer Research 65・9

      Pages: 3823-3827

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Herpes simplex virus type 1 mutant HF10 oncolytic viral therapy for bladder cancer2005

    • Author(s)
      Kohno S, Luo C, Goshima F, Nishiyama Y, Sata T, Ono Y
    • Journal Title

      Urology 66・5

      Pages: 1116-1121

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] Herpes simplex virus and varicella-zoster virus : why do these human alphaherpesviruses behave so differently from one another?2005

    • Author(s)
      Mori I, Nishiyama Y
    • Journal Title

      Reviews in Medical Virology 15・6

      Pages: 393-406

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The role of protein kinase activity expressed by the UL13 gene of herpes simplex virus 1 : the activity is not essential for optimal expression of UL41 and ICPO2005

    • Author(s)
      Tanaka M, Nishiyama Y, Sata T, Kawaguchi Y
    • Journal Title

      Virology 341・2

      Pages: 301-312

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The potential of oncolytic virus therapy for pancreatic cancer.2005

    • Author(s)
      Kasuya H, Takeda S, Nomoto S, Nakao A.
    • Journal Title

      Cancer Gene Therapy 12-9

      Pages: 725-736

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Mouse models of subcutaneous spleen reservoir for multiple portal venous injections to treat liver malignancies.2005

    • Author(s)
      Kasuya H, Kuruppu DK, Donahue JM, Choi EW, Kawasaki H, et al.
    • Journal Title

      Cancer Research 65-9

      Pages: 3823-3827

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Herpes simplex virus type 1 mutant HF10 oncolytic viral therapy for bladder cancer2005

    • Author(s)
      Kohno S, Luo C, Goshima F, Nishiyama Y, Sata T, Ono Y.
    • Journal Title

      Urology 66-5

      Pages: 1116-1121

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Herpes simplex virus and varicella-zoster virus : why do these human alphaherpesviruses behave so differently from one another?2005

    • Author(s)
      Mori I, Nishiyama Y.
    • Journal Title

      Reviews in Medical Virology 15-6

      Pages: 393-406

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The role of protein kinase activity expressed by the UL13 gene of herpes simplex virus 1 : the activity is not essential for optimal expression of UL41 and ICPO.2005

    • Author(s)
      Tanaka M, Nishiyama Y, Sata T, Kawaguchi Y.
    • Journal Title

      Virology 341-2

      Pages: 301-312

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The Potential of Oncolytic Virus Therapy for Pancreatic Cancer2005

    • Author(s)
      Kasuya H, Nomoto S, Takeda S, Nakao A
    • Journal Title

      Cancer Gene Therapy 12・9

      Pages: 725-736

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Mouse models of subcutaneous spleen reservoir for multiple portal venous injections to treat liver malignancies2005

    • Author(s)
      Kasuya H, Kuruppu DK, Donahue JM, Choi EW, Kawasaki H, Tanabe KK.
    • Journal Title

      Cancer Research 65・9

      Pages: 3823-3827

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Herpes simplex virus and varicella-zoster virus : why do these hum alphaherpesviruses behave so differently from one another?2005

    • Author(s)
      Mori I, Nishiyama Y
    • Journal Title

      Reviews in Medical Virology 15・6

      Pages: 393-406

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The role of protein kinase activity expressed by the UL13 gene of herpes simplex virus 1 : the activity is not essential for optimal expression of UL41 and ICP02005

    • Author(s)
      Tanaka M, Nishiyama Y, Sata T, Kawaguchi Y
    • Journal Title

      Virology 341・2

      Pages: 301-312

    • Related Report
      2005 Annual Research Report
  • [Journal Article] ヘルペスウイルスHF10による乳癌治療の最新研究2004

    • Author(s)
      木全秀人, 勅使河原修, 西山幸廣, 中尾昭公
    • Journal Title

      日本臨牀 62・5

      Pages: 987-993

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Intratumoral injection of herpes simplex virus HF10 in recurrent breast cancer2004

    • Author(s)
      Nakao A, Kimata H, Imai T, Kikumori T, et al.
    • Journal Title

      Annals of Oncology 15・6

      Pages: 988-989

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Oncolytic Viral Therapy for Breast Cancer With Herpes Simplex Virus Typel Mutant HF102004

    • Author(s)
      Teshigahara O, Goshima F, Takao K et al.
    • Journal Title

      Journal of Surgical Oncology 85

      Pages: 42-47

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Novel treatment with oncolytic herpes simplex virus, 'HF10' against breast cancer.2004

    • Author(s)
      Kimata H, Teshigahara O, Nishiyama Y, Nakao A.
    • Journal Title

      Nippon Rinsho 62-5

      Pages: 987-993

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Intratumoral injection of herpes simplex virus HF10 in recurrent breast cancer.2004

    • Author(s)
      Nakao A, Kimata H, Imai T, Kikumori T, et al.
    • Journal Title

      Annals of Oncology 15-6

      Pages: 988-989

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Oncolytic viral therapy for breast cancer with herpes simplex virus typel mutant HF 10.2004

    • Author(s)
      Teshigahara O, Goshima F, Takao K, Hohno S, Kimata H, et al.
    • Journal Title

      Journal of Surgical Oncology 85-1

      Pages: 42-47

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Intratumoral injection of herpes simplex virus HF10 in recurrent breast cancer2004

    • Author(s)
      Nakao A, Kimata H, Imai T, Kikumori T, Teshigahara O, Nagasaka T, Goshima F, Nishiyama Y.
    • Journal Title

      Annals of Oncology 15

      Pages: 987-991

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Oncolytic Viral Therapy for Breast Cancer With Herpes Simplex Virus Type1 Mutant HF102004

    • Author(s)
      Teshigahara O, Goshima F, Takao K, Hohno S, Kinamta H, Nakao A, Nishiyama Y.
    • Journal Title

      Journal of Surgical Oncology 85

      Pages: 42-47

    • Related Report
      2004 Annual Research Report
  • [Journal Article] The Potential of Oncolytic Virus Therapy for Pancreatic Cancer

    • Author(s)
      Kasuya H, Nomoto S, Takeda S, Nakao A.
    • Journal Title

      Cancer Gene Therapy Accepted ; January 2005

    • Related Report
      2004 Annual Research Report
  • [Book] ヘルペスウイルス学-基礎・臨床研究の進歩-2006

    • Author(s)
      粕谷英樹, 中尾昭公
    • Total Pages
      691
    • Publisher
      日本臨牀社
    • Related Report
      2005 Annual Research Report
  • [Patent(Industrial Property Rights)] 変異単純ヘルペスウイルスからなる転移性乳癌および再発乳癌の治療剤2004

    • Inventor(s)
      中尾昭公, 西山幸廣
    • Industrial Property Rights Holder
      中尾昭公, 西山幸廣
    • Filing Date
      2004-05-26
    • Acquisition Date
      2005-12-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary

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Published: 2004-04-01   Modified: 2016-04-21  

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