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Clinical approach of cancer of the esophagus specific treatment based on an individualization of a gene expression pattern

Research Project

Project/Area Number 16390387
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionHOKKAIDO UNIVESITY

Principal Investigator

KONDO Satoshi  Hokkaido University, Graduate School of medicine, Professor, 大学院・医学研究科, 教授 (30215454)

Co-Investigator(Kenkyū-buntansha) MIYAMOTO Masaki  Hokkaido University, Hokkaido University Hospital, Assistant, 助手 (40333611)
守内 哲也  北海道大学, 遺伝子病制御研究所, 教授 (20174394)
多田 光宏  北海道大学, 遺伝子病制御研究所, 助教授 (10241316)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥12,600,000 (Direct Cost: ¥12,600,000)
Fiscal Year 2005: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 2004: ¥10,200,000 (Direct Cost: ¥10,200,000)
Keywordsesophageal cancer / gene diagnosis / E2F-1 / DARPP-32 / CyclinD1 / PEDF / gene therapy / 予後 / 腫瘍特異的抗原 / マイクロアレイ
Research Abstract

We investigated the immunoreactivity of E2F-1,DARPP-32,CyclinD1, and PEDF in 122 patients with esophageal squamous cell cancer. (ESCC) Subsequently, we analyzed the correlation between the gene expression and clinicopathological features. Overexpression of E2F-1 or CyclinD1 correlatesd with tumor progression and s worse prognosis after surgery in ESCC. Moreover, we performed a mufti-institutional analysis of E2F-1 and cyclinD1 expression in patients with ESCC. E2F-1/cyclinD1(-/-) tumors correlated with reduced tumor progression. DARPP-32 expression was hardly seen in normal esophageal mucous and dysplasia, but it arised after a phase of dysplasia in ESCC. However, patients with DARPP-32 positive tumor showed a favorable prognosis. Expression of t-DARPP, which is one of DARPP isoforms, was not seen in ESCC. PEDF expression was seen in normal esophageal mucous and its expression in ESCC inversely correlated with the malignant features. Downregulation of PEDF correlated with lymph nodal metastasis. Then, genetic diagnoses of E2F-1,DARPP-32,CyclinD1, and PEDF expressions would be useful to assess the malignancy of ESCC. Moreover, since secreted PEDF from cells suppresses the growth and the migration of surrounding vascular endothelial cells, PEDF gene therapy may provide a new approach for treatment of cancer.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report

Research Products

(5 results)

All 2006 2005 2004

All Journal Article

  • [Journal Article] Pigment Epithelium-Derived Factor Gene Therapy Inhibits Human Pancreatic Cancer in Mice2006

    • Author(s)
      R Hase, M Miyamoto, et al.
    • Journal Title

      Clinical Cancer Research 11(24)

      Pages: 8737-8744

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Cyclin D1, E2F1 expression levels are associated with characteristics and prognosis of esophageal squamous cell carcinoma2005

    • Author(s)
      S Mega, S Kondo, et al.
    • Journal Title

      Disease of Esophagus 18

      Pages: 109-113

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Pigment Epithelium-Derived Factor Gene Therapy Inhibits Human Pancreatic cancer in Mice2005

    • Author(s)
      R Hase, S Kondo, et al.
    • Journal Title

      Clinical Cancer Research 11(24)

      Pages: 8737-8744

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Over-expression of E2F-1 in esophageal squamous cell carcinoma correlates with tumor progression2004

    • Author(s)
      Y Ebihara, S Kondo, et al.
    • Journal Title

      Disease of Esophagus 17

      Pages: 150-154

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] DARPP-32 expression arises after a phase of dysplasia in oesophageal squamous cell carcinoma2004

    • Author(s)
      Y Ebihara, S Kondo, et al.
    • Journal Title

      British Journal of Cancer 91

      Pages: 119-123

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary

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Published: 2004-04-01   Modified: 2016-04-21  

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