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Remodeling of vein graft in noromocholesterolemic or hypercholesterolemic rabbits

Research Project

Project/Area Number 16390391
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionTokyo Medical and Dental University

Principal Investigator

TANAKA Hiroyuki  Tokyo Medical and Dental University, Graduate School, Thoracic Cardiovascular Surgery, Associate Professor, 大学院医歯学総合研究科, 助教授 (70197466)

Co-Investigator(Kenkyū-buntansha) SUZUKI Jun-ichi  Tokyo Medical and Dental University, Hospital Faculty of Medicine, Assistant, 医学部附属病院, 助手 (90313858)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥8,600,000 (Direct Cost: ¥8,600,000)
Fiscal Year 2005: ¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2004: ¥5,200,000 (Direct Cost: ¥5,200,000)
Keywordsvein graft / hypercholesterolemia / rabbit / 高コレステロール血症
Research Abstract

We studied the remodeling of vein graft implanted into the carotid artery in normo-or hypercholesterolemic rabbit. Vein grafts were harvested 8weeks after surgery and evaluated by pathological characteristics. Hypercholesterolemia (800mg/dl) significantly decrease the patency rate (35%) compared to that in normocholesterolemic (50mg/dl) rabbits (83%) at 8 weeks post surgery. In patent vein grafts of hypercholesterolemic rabbits, focal foamy cell rich lesions and luminal fibrin-like thrombus were observed along with fibroproliferative lesions. In vein grafts in normocholesterolemic rabbits, intimal thickening consited of only SMC proliferation and no macrophages, were observed and lumen was widely open, suggesting that SMC proliferation was adaptive response of vein graft implanted in high pressure circulation and not cause of graft occlusion. In some occluded vein grafts, luminal thrombus formation that seemed to be derived from foamy cell rich lesions, was observed. These pathological findings suggested that rupture of unstable plaque and subsequent thrombus formation play a crucial role in mechanism of vein graft occlusion. We also evaluated the effects of ACAT inhibition on vein graft remodeling. ACAT inhibition did not improve the patency rate of vein graft in hypercholesterolemic rabbits, It may tend to stabilize the lesion characteristics, but there was no significant difference in lesion size, area of foamy cell rich lesions between treated group and control group.
As clinical implications, aggressive cholesterol lowering therapy and anticoagulation therapy may be important in post operative medical therapy after bypass surgery and therapeutic target must be focused on the stabilization of the plaque on vein grafts.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (2 results)

All 2005

All Journal Article (2 results)

  • [Journal Article] 高コレステロール血症の静脈グラフトに及ぼす影響に関する実験的検討2005

    • Author(s)
      恵木康壮, 田中啓之, 荒井裕国, 砂盛 誠
    • Journal Title

      日本胸部外科学会誌 53 Suppl II

      Pages: 431-431

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effect of hypercholesterolemis on rabbit vein graft2005

    • Author(s)
      Egi K, Tanaka H, Arai H, Sunamori M
    • Journal Title

      Jap J Thorac Cardiovasc Surg. 53(Suppl II)

      Pages: 431-431

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary

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Published: 2004-04-01   Modified: 2016-04-21  

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