| Project/Area Number |
16390422
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Osaka Medical College |
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Principal Investigator |
MIYATAKE Shinichi Osaka Medical College, Faculty of Medicine, Associate Professor, 医学部, 助教授 (90209916)
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| Co-Investigator(Kenkyū-buntansha) |
KAJIMOTO Yoshinaga Osaka Medical College, Faculty of Medicine, Assistant Professor, 医学部, 講師 (30224413)
KUROIWA Toshiko Osaka Medical College, Faculty of Medicine, Professor, 医学部, 教授 (30178115)
ONO Koji Kyoto Univ., Research Reactor Inst., Professor, 原子炉実験所, 教授 (90122407)
KIRIHATA Mitsunori Osaka Pref.Univ., Faculty of Agriculture, Professor, 大学院・農学生命科学研究科, 教授 (60128767)
YOSHIDA Toshiko Toyama Univ., Faculty of Medicine, Assoc.Prof., 医学部, 助教授 (00171421)
丸山 一雄 帝京大学, 薬学部, 教授 (30130040)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥14,400,000 (Direct Cost: ¥14,400,000)
Fiscal Year 2005: ¥5,500,000 (Direct Cost: ¥5,500,000)
Fiscal Year 2004: ¥8,900,000 (Direct Cost: ¥8,900,000)
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| Keywords | BNCT / BPA / BSH / PET / GBM / SIMS / Transferrin / glioma / liposome / transferin |
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| Research Abstract |
We have developed the modern radiation technology, boron neutron capture therapy (BNCT) on malignant brain tumors. By this technology, almost all malignant brain tumors showed remarkable shrinkage of the mass in neuron-imaging. To augment this efficacy, we studied this technology with several modifications and fundamental experiments. Briefly, we used 2 different boron compounds BPA and BSH, simultaneously and after BNCT, we added fractionated XRT with 20 to 30Gy. These modification contributed to the prolonged survival of the patients of GBM to 22 months as MST.
In animal experiments, we used secondary ion mass spectroscopy (SIMS) for the analysis of the localization of boron compound. In rat brain tumor models, SIMS analysis revealed BPA accumulates in homogeneously, while BSH does homogeneously and synergistic accumulation was observed with the combination of the compounds.
Also we studied the efficacy of transferrin-PEG liposome as drug delivery system (DDS) of boron carrier. This DDS augments the intracellular accumulation of boron atoms more efficiently than other DDS and resulted in prolonged survival in animal brain tumor models with neutron irradiation.
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