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A New Preventative Strategy Targeting a Specific Novel Protein against Human Bone Metastases

Research Project

Project/Area Number 16390445
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionKurume University

Principal Investigator

NAGATA Kensei  Kurume University, School of Medicine, Professor (50140687)

Co-Investigator(Kenkyū-buntansha) SATA Michio  Kurume University, School of Medicine, Professor (10162398)
TSURU Michiyo  Kurume University, Biotechnology Statistics Center, Researcher (90368887)
YAMAGUCHI Takehiko  Sapporo Medical University, School of Medicine, Associate professor (80245125)
TAKEUCHI Masahiro  Kitasato University, Graducate School Center for Clinical Sciences Division of Biostatistics, Professor (30317060)
SATO Kimiaki  Kurume University, School of Medicine, Associate professor (90268912)
自見 厚郎  久留米大学, 医学部, 教授 (90140897)
角間 辰之  久留米大学, 先端癌治療研究センター, 客員教授 (50341540)
Project Period (FY) 2004 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥14,490,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥990,000)
Fiscal Year 2007: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2006: ¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2005: ¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2004: ¥3,600,000 (Direct Cost: ¥3,600,000)
Keywordsbone metastasis / biomarker / survival / amino acid structure analysis / proteomics / preclinical examination study / In Sillico 創薬 / トランスレーショナルリサーチ / がん / 転移 / 予防 / アミノ酸構造 / 創薬 / 生存時間 / バイオメーカー / プロテオーム / ICH / プロテオミクス / 早期発見 / 骨転移バイオマーカー / Biostatistics / Bridging study / 特許 / がん骨転移予防
Research Abstract

The leading cause of death in our country has been cancer since 1981. The total number of deaths from cancer reached 304,286 in 2002, with a mortality rate of 241.5 per 100,000, accounting for 31.0% of all deaths in 2002. Bone metastasis is found in 25-50% of terminal cancer patients, and it is thought that 70,000-150,000 terminal-stage cancer patients are presently suffering from bone metastasis. Bones are common sites for cancer metastases. Maintaining the QOL of these patients is an urgent concern in order to help these patients live with full dignity. Therefore we are using medical technology to identify molecular target proteins of bone metastasis using proteomics in order to facilitate early diagnosis at low cost. Names of the donors of patient samples were blinded in accordance with the 'Ethical Guidelines for Human Genomic/Genetic Studies' of the Ministry of Health, Labor, and Welfare, Ministry of Education, Culture, Sports, Science, and Technology, and Ministry of Economy, Tra … More de, and Industry, and the FDA 21 CFR part 11. Use of proteomics patterns in serum to identify bone metastasis tumor by SELDI-TOF (BioRad). A prospective study was undertaken in 47 patients with liver cancer, to identify which proteins were characteristic and predictive of bone metastasis. Of these patients, bone metastasis developed in 11 cases, and this protein was identified before bone metastasis was confirmed in bone scintigraphy of all patients. This result yielded a sensitivity of 100%. Also, among these patients, peak values of the protein were found in 10 cases. At present, the follow-up investigation is under way because the results of bone scintigraphy did not reveal bone metastasis. An important characteristic of the protein we identified was that it was detectable at about average at 6-11 months before diagnosis in these patients, much earlier than bone metastases can be imaged by bone scintigraphy. In addition, we quantified this protein from the areas under the curves by mass spectrometry, and found that the protein continued to increase in serum up to the time when bone metastasis was confirmed by bone scintigraphy and then decreased after the start of radiotherapy treatment.
[This protein shows below important significance to become biomarker of bone metastasis]
1. Preparation of the patient to measure is serum.
2. Measurement time is short.
3. This protein recognized earlier than bone scintigraphy.
[This protein shows below important clinical significance to bone metastasis]
1. Prevention of bone metastasis is enabled.
2. We can make inhibitor of this protein. Expectation to pharmaceuticals for prevention of bone metastasis.
3. The pain of bone metastasis will be gone eternally.
4. Macrobiotic expectation of the cancer patients.
We have used proteomics technology to identify a novel protein as a molecular target for bone metastasis and demonstrated its potential use for early diagnosis at low cost. Large-scale clinical trials will now be needed, to prove the usefulness of this approach, but the potential offered for early diagnosis using this protein could also enable far more effective treatment for bone metastasis in the future. Less

Report

(5 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (30 results)

All 2007 2006 2005 2004 Other

All Journal Article (4 results) Presentation (17 results) Book (1 results) Remarks (3 results) Patent(Industrial Property Rights) (5 results) (of which Overseas: 2 results)

  • [Journal Article] 骨疾患プロテオーム2004

    • Author(s)
      津留 美智代
    • Journal Title

      遺伝子医学MOOK疾患プロテオミクスの最前線-プロテオミクスで病気は治せるか 2

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] トランスレーショナル・リサーチの体制づくりと人材育成2004

    • Author(s)
      津留 美智代
    • Journal Title

      羊土社Bioベンチャー 4

      Pages: 66-68

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The biostatistics talented person training in practice of Translational Research2004

    • Author(s)
      Michiyo Tsuru, Kensei Nagata
    • Journal Title

      Bio-venture, Yodosha.co. Vol.4 No.3

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Can you cure a disease in battle front-proteomics of disorder proteomics? Discovery of a specific target protein in a human bone metastasis tumor and establishment of a new preventive treatment strategy2004

    • Author(s)
      Michiyo Tsuru, Kensei Nagata
    • Journal Title

      Gene medicine MOOK

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A New Preventative Strategy Targeting a Specific Novel Protein against Human Bone Metastases2007

    • Author(s)
      永田 見生
    • Organizer
      AstraZeneca R & D Alderley Park創薬研究所
    • Place of Presentation
      英国
    • Year and Date
      2007-10-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A New Preventative Strategy Targeting a Specific Novel Protein against Human Bone Metastases2007

    • Author(s)
      永田 見生
    • Organizer
      AstraZeneca R& D Alderley Park 創薬研究所
    • Place of Presentation
      英国
    • Year and Date
      2007-10-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] プロテオミクスからのヒト骨転移バイオマーカーの前臨床試験2007

    • Author(s)
      津留 美智代
    • Organizer
      第5回北里疾患プロテオーム研究会
    • Place of Presentation
      神奈川
    • Year and Date
      2007-08-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] ヒト骨転移バイオマーカー臨床試験結果報告2007

    • Author(s)
      津留 美智代
    • Organizer
      第3回日本臨床プロテオーム研究会
    • Place of Presentation
      東京
    • Year and Date
      2007-04-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] プロテオミクスからのヒト骨転移バイオマーカーの発見とその臨床的有用性2007

    • Author(s)
      津留 美智代
    • Organizer
      第2回日本臨床プロテオーム研究会(JSCP), 第4回日本ヒトプロテオーム機構(JHUPO)連合大会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ヒト骨転移バイオマーカー臨床試験結果報告2007

    • Author(s)
      津留 美智代
    • Organizer
      第5回日本ヒトプロテオーム機構(JHUPO)大会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] プロテオミクスからのヒト骨転移バイオマーカーの発見とその臨床的有用性2007

    • Author(s)
      津留 美智代
    • Organizer
      第2回日本臨床プロテオーム研究会(JSCP)、第4回日本ヒトプロテオーム機構(JHUPO)連合大会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] ヒト骨転移バイオマーカーの発見と多施設共同試験の結果報告2006

    • Author(s)
      津留 美智代
    • Organizer
      第79回日本整形外科学会学術集会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] プロテオミクスからのヒト骨転移バイオマーカーの発見とその臨床的有用性2006

    • Author(s)
      津留 美智代
    • Organizer
      第2回日本臨床プロテオーム研究会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 骨転移バイオマーカーの前臨床試験の効果と臨床的有用性2006

    • Author(s)
      津留 美智代
    • Organizer
      第21回日本整形外科学会基礎学術集会 シンポジウム
    • Place of Presentation
      長崎
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Discovery of a specific target protein in a human bone metastasis tumor and establishment of a new preventive treatment strategy2006

    • Author(s)
      Michiyo Tsuru, Kensei Nagata, Takehiko Yamaguchi, Michio Sata
    • Organizer
      Proceedings of the 79th Annual Meeting of the Japanese Orthopaedic Association
    • Place of Presentation
      Yokohama, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] プロテオミクスからのヒト骨転移バイオマーカーの発見と臨床応用2005

    • Author(s)
      津留 美智代
    • Organizer
      第8回 癌と骨病変研究会
    • Place of Presentation
      東京
    • Year and Date
      2005-11-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] プロテオミクスからのヒト骨転移バイオマーカーの発見と臨床応用2005

    • Author(s)
      津留 美智代
    • Organizer
      第20回日本整形外科学会基礎学術集会 シンポジウム
    • Place of Presentation
      伊勢
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 骨疾患プロテオミクス2005

    • Author(s)
      津留 美智代
    • Organizer
      疾患プロテオミクス最前線 シンポジウム 九州バイオサイエンスシンポジウム
    • Place of Presentation
      熊本
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Discovery and clinical application of Homo sapiens metastases to bone biomarker from proteomics2005

    • Author(s)
      Michiyo Tsuru, Kensei Nagata, Takehiko Yamaguchi, Michio Sata
    • Organizer
      Proceedings of the 20th Annual Meeting of the Japanese Orthopaedic Association.
    • Place of Presentation
      Ise, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] プロテオミクスによる,がん研究の新戦略 骨転移プロテオーム解析からの臨床応用2004

    • Author(s)
      津留 美智代
    • Organizer
      第63回日本癌学会学術総会 シンポジウム
    • Place of Presentation
      福岡
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Discovery of a specific target protein in a human bone metastasis tumor and establishment of a new preventive treatment strategy2004

    • Author(s)
      Michiyo Tsuru, Kensei Nagata, Takehiko Yamaguchi, Michio Sata
    • Organizer
      The 63th Annual Meeting of the Japanese Cancer Association.
    • Place of Presentation
      Fukuoka, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 遺伝子医学MOOK「疾患プロテオミクスの最前線」骨疾患プロテオミクス2005

    • Author(s)
      戸田年総, 荒木令江, 分担/津留美智代, 永田見生
    • Publisher
      株式会社メディカル ドゥ
    • Related Report
      2004 Annual Research Report
  • [Remarks] 「研究成果報告書概要(和文)」より

    • Related Report
      2007 Final Research Report Summary
  • [Remarks]

    • URL

      http://www.med.kurume-u.ac.jp/med/orth/index.html

    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.kurume-u.ac.jp/med/orth/nichidoku/index.html

    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] NOVEL BONE METASTASIS MARKER PEPTIDE AND MET HOD OF DIAGNOSING BONE METASTASIS BY USING THE SAME2007

    • Inventor(s)
      M.TSURU., K.NAGATA., M.SATA.
    • Industrial Property Rights Holder
      KURUME UNIV ERSITY
    • Filing Date
      2007-03-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Overseas
  • [Patent(Industrial Property Rights)] NOVEL BONE METASTASIS MARKER PEPTIDE AND MET HOD OF DIAGNOSING BONE METASTASIS BY USING THE SAME2007

    • Inventor(s)
      M.TSURU., K.NAGATA., M.SATA.
    • Industrial Property Rights Holder
      KURUME UNIV ERSITY
    • Filing Date
      2007-03-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Overseas
  • [Patent(Industrial Property Rights)] 新規骨転移マーカーペブチドおよびそれを用いた骨転移の診断方法2005

    • Inventor(s)
      津留 美智代, 永田 見生, 佐田 通夫
    • Industrial Property Rights Holder
      久留米大学
    • Filing Date
      2005-09-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 新規骨転移マーカーペプチドおよびそれを用いた骨転移の診断方法2005

    • Inventor(s)
      津留 美智代, 永田 見生, 佐田 通夫
    • Industrial Property Rights Holder
      久留米大学
    • Filing Date
      2005-10-19
    • Related Report
      2005 Annual Research Report
  • [Patent(Industrial Property Rights)] 新規骨転移マーカーペプチドおよびそれを用いた骨転移の診断方法2004

    • Inventor(s)
      津留 美智代, 永田 見生, 佐田 通夫
    • Industrial Property Rights Holder
      久留米大学
    • Filing Date
      2004
    • Acquisition Date
      2004
    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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