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Preventive effects of masticatory stimulus on senile dementia : a fMRI study

Research Project

Project/Area Number 16390568
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 補綴理工系歯学
Research InstitutionKanagawa Dental College

Principal Investigator

ONOZUKA Minoru  Kanagawa Dental College, Dentistry, Professor, 歯学部, 教授 (90084780)

Co-Investigator(Kenkyū-buntansha) SATO Sadao  Kanagawa Dental College, Dentistry, Professor, 歯学部, 教授 (00084799)
UEMATSU Hiroshi  Tokyo Medical and Dental University, Professor, 大学院・医歯学総合研究科, 教授 (80100957)
KATO Norihiro  Gifu University Hospital, Faculty of Medicine, Associate professor, 医学部付属病院, 助教授 (40224521)
KANEMATSU Masayuki  Gifu University Hospital, Faculty of Medicine, Associate professor, 医学部付属病院, 助教授 (40252134)
WATANABE Kazuko  Gifu University, Graduated School of Medicine, Associate professor, 大学院・医学系研究科, 助教授 (40158621)
塗々木 和男  神奈川歯科大学, 歯学部, 講師 (90139577)
西山 勝弘  神奈川歯科大学, 歯学部, 講師 (20084783)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥14,500,000 (Direct Cost: ¥14,500,000)
Fiscal Year 2005: ¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2004: ¥11,200,000 (Direct Cost: ¥11,200,000)
KeywordsDementia / Occulusion / Mastication / Functional MRI / Hippocampus / Pre-frontal cortex / Memory / Dentures / 痴呆 / 認知障害 / 磁器共鳴機能画像 / 神経ネットワーク
Research Abstract

The goal of this project is to elucidate the crosstalk mechanism(s) between the masticatory organs and the cerebral cortex including the hippocampus. Especially, we focused on the preventive effects of occlusal or masticatory stimulus on memory processes in aged humans, by the functional magnetic resonance imaging (fMRI) and behavioral science. In the first experiment, using fMRI during cycles of rhythmic gum-chewing and no chewing, we examined the effect of aging on brain regional activity during chewing in young adult, middle-aged, and aged intact humans. In all subjects, chewing resulted in a bilateral increase in the BOLD signals in the sensorimotor cortex, cerebellum, thalamus, supplementary motor area, and insula, and a unilateral increase in the right prefrontal area. In the first three regions, the signal increases were attenuated in an age-dependent manner, whereas, in the right prefrontal area, the converse was seen. The remaining two regions showed no significant differences with ages.
We did another fMRI experiment, in which we examined the effect of chewing on the hippocampal activities, by employing a task using photographs containing spatial cognitive function. As a result, the hippocampus in young subjects was strongly activated, but no significant difference was seen between before and after chewing. In contrast, activation in the elderly was quite small in comparison with the young subjects. However, the activation area and the intensity of fMRI signals increased by chewing. Furthermore, according to the results from the recall test, aged subjects showed a significant increase in memory acquisition after chewing. Either combined effect of chewing training and communication during meals or the case of the denture wearers on memory acquisition was also significant. From the above results, we strongly suggest that, in the elderly, occlusal or masticatory stimulus causes an enhancement in hippocampus-dependent memory acquisition.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (16 results)

All 2005 2004 Other

All Journal Article (15 results) Book (1 results)

  • [Journal Article] Immunohistochemical analysis of monoaminergic neurons in the braqin of the common manoset, Calithric jaccus2005

    • Author(s)
      Karasawa N
    • Journal Title

      Acta Histochemica et Cytochemica 38

      Pages: 353-356

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Sensitivity of serotonin synthesis to synthesis inhibitor GTP cyclohydrolase I in sensesenceaccelerated mouse-prone inbred strain2005

    • Author(s)
      Karasawa N
    • Journal Title

      Acta Histochemica et Cytochemica 38

      Pages: 367-371

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Ventral lateral geniculate nucleus projects to dorsal lateral geniculate nucleus in the cat2005

    • Author(s)
      Nakamura H
    • Journal Title

      Neuroreport 16

      Pages: 1575-1578

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Molarless-induced changes of spines in hippocampal region of SAMP8 mice2005

    • Author(s)
      Kubo K
    • Journal Title

      Brainn Research 1057

      Pages: 191-195

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Skull base metastasis from hepatocellular carcinoma revealed by cranial nerve palsy : reports of two cases2005

    • Author(s)
      Kato H
    • Journal Title

      European Jouranl of Radiology Extra 54

      Pages: 1-4

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Suppression of stress immobilization-induced phosphorylation of ERK 1/2 by biting in the rat hypothalamic paraventricular nucleus2005

    • Author(s)
      Sasaguri K
    • Journal Title

      Neuroscience Letters 383

      Pages: 160-164

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Immunohistochemical analysis of monoaminergic neurons in the braqin of the common manoset, Calithric jaccus2005

    • Author(s)
      Karasawa N et al.
    • Journal Title

      Acta Histochemica et Cytochemica 38

      Pages: 353-356

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] ensitivity of serotonin synthesis to synthesis inhibitor GTP cyclohydrolase I in sensesenceaccelerated mouse-prone inbred strain2005

    • Author(s)
      SKarasawa N et al.
    • Journal Title

      Acta Histochemica et Cytochemica 38

      Pages: 367-371

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Ventral lateral geniculate nucleus projects to dorsal lateral geniculate nucleus in the cat2005

    • Author(s)
      Nakamura H et al.
    • Journal Title

      Neuroreport 16

      Pages: 1575-1578

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Molarless-induced changes of spines in hippocampal region of SAMP8 mice2005

    • Author(s)
      Kubo K et al.
    • Journal Title

      Brain Research 1057

      Pages: 191-195

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Skull base metastasis from hepatocellular carcinoma revealed by cranial nerve palsy : reports of two cases2005

    • Author(s)
      Kato H et al.
    • Journal Title

      European Journal of Radiology Extra 54

      Pages: 1-4

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Molarless-induced changes of spines in hippocampal region of SAMP8 mice2005

    • Author(s)
      Kubo K
    • Journal Title

      Brain Research 1057

      Pages: 191-195

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Optimizing scan delays of fixed duration contrast injection in contrast-enhanced biphasic multi-detector row CT for the liver and the detection of hypervascular hepatocellular carcinoma.2005

    • Author(s)
      Kanematsu M
    • Journal Title

      J Comput Assist Tomogr

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 前頭前野と咀嚼運動2005

    • Author(s)
      藤田雅文, 渡邊和子, 平野好幸, 小野塚実
    • Journal Title

      Clinical Neuroscience (In press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Suppression of stress immobilization-induced phosphorylation of ERK 1/2 by biting in the rat hypothalamic paraventricular nucleus

    • Author(s)
      Sasaguri K et al.
    • Journal Title

      Neuroscience Letters

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 歯周病と全身の健康を考える(分担)2004

    • Author(s)
      渡邊和子, 藤田雅文, 小野塚実
    • Total Pages
      362
    • Publisher
      医歯薬出版
    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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