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Development of the noble biomaterial for re-implantation to host consisiting of chondrocyte culture system and titanium system

Research Project

Project/Area Number 16390571
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 補綴理工系歯学
Research InstitutionAichi-Gakuin University

Principal Investigator

KAWAI Tatsushi  Aichi-Gakuin University, Proffessor, 歯学部, 教授 (60167351)

Co-Investigator(Kenkyū-buntansha) MAEDA Hatsuhiko  Aichi-Gakuin University, Associate Professor, 歯学部, 助教授 (30175591)
YOSHINANK Nobuo  Aichi-Gakuin University, Lecturer, 歯学部, 講師 (20231699)
TSURUTA Shozo  Aichi-Gakuin University, Associate Professor, 歯学部, 助教授 (40183488)
HAYASHI Tatsuhide  Aichi-Gakuin University, Assistant Professor, 歯学部, 助手 (70367621)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥11,900,000 (Direct Cost: ¥11,900,000)
Fiscal Year 2005: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 2004: ¥7,900,000 (Direct Cost: ¥7,900,000)
KeywordsBMP / Bone morphogenetic protein / Diffusion chamber / Biomaterial / Functionalmaterial / Implant / Bone induce / Titanium / チタン
Research Abstract

Host derived chondrocyte culture system and BMP-biomaterial composite system were integrated to promote the biological activity of chondrocyte. Experiment was performed mainly on the basis of porous titanium frame work. Porous titanium and bone morphogenetic protein was stably produced, and the culture work on porous titanium was successfully completed. New bone formation was observed by BMP-porous composite system, and chondrocyte-porous titanium system induced cartilage in vivo but no new bone formation. Diffusion chamber system was newly established to culture cells not in the in vitro system but inner body culture system. This system showed large amount of calcification in the chamber. As mentioned as above, primarily objectives of this project was successfully performed, and related research works raised new findings which were concerned with biological effect of titanium oxide, which is the thin surface layer of titanium, and with effectiveness of DNA micro array system for the molecular biological understanding. The future work based on these valuable information will be carried out in the next project.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (20 results)

All 2006 2004

All Journal Article (20 results)

  • [Journal Article] Global gene expression analyses of mouse fibroblast L929 cells exposed to IC50MMA by DNA microarray and confirmation of four detoxification genes'expression by real-time PCR.2006

    • Author(s)
      Ishikawa, A., et al.
    • Journal Title

      Dent. Mater. J. 25・2

      Pages: 205-213

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Influence of newly developmed resin and MMA resin on mouse fibroblasts cellular viability.2006

    • Author(s)
      Jinno, S., et al.
    • Journal Title

      Key Engineering materials 309・311

      Pages: 817-820

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Influence of novel resin monomer on viability of L-929 mouse fibroblasts in vitro.2006

    • Author(s)
      Jinno, S., et al.
    • Journal Title

      Dent. Mater. J. 25・4

      Pages: 693-699

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The biological properties of a novel ethyl methacrylate resin.2006

    • Author(s)
      Suzuki, T., et al.
    • Journal Title

      J. Int. Med. Res. 34

      Pages: 256-263

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Bone repair of rabbit mandibulartranssection using uhBMP-2 and atelocollagen gel.2006

    • Author(s)
      Kimura, A., et al.
    • Journal Title

      Euro. J. Med. Res. 11

      Pages: 355-358

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Global gene expression analyses of mouse fibroblast L929 cells exposed to IC5OMMA by DNA microarray and confirmation of four detoxification genes'expression by real-time PCR2006

    • Author(s)
      Ishikawa, A. et al.
    • Journal Title

      Dent. Mater. J. 25(2)

      Pages: 205-213

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Influence of newly developmed resin and MMA resin on mouse fibroblasts cellular viability.2006

    • Author(s)
      Jinno, S., et al.
    • Journal Title

      Key Engineering materials 309-311

      Pages: 817-820

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Influence of novel resin monomer on viability of L-929 mouse fibroblasts in vitro.2006

    • Author(s)
      Jinno, S., et al.
    • Journal Title

      Dent. Mater. J. 25(4)

      Pages: 693-699

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The biological properties of a novel ethyl methacrylate resin.2006

    • Author(s)
      Suzuki, T.,.et al.
    • Journal Title

      J.Int. Med. Res. 34

      Pages: 256-263

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Bone repair of rabbit mandibular transsection using rhBMP-2 and atelocollagen gel.2006

    • Author(s)
      Kimura, A., et al.
    • Journal Title

      Euro. J. Med. Res. 11

      Pages: 355-358

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Global gene expression analyses of mouse fibroblast L929 cells exposed to IC50 MMA by DNA microarray and confirmation of four de-toxication gene's expression by real-time PCR.2006

    • Author(s)
      Ishikawa, A., et al.
    • Journal Title

      Dent.Mater.J. 25(2)(in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Possibility of clinical usage of BMP in periodontal application-basic study.2006

    • Author(s)
      Jinno, S., et al.
    • Journal Title

      Clinical Calcium 16(2)

      Pages: 326-331

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Influence of newly developed resin and MMA resin on mouse fibroblasts cellular viability2006

    • Author(s)
      Jinno, S., et al.
    • Journal Title

      Key Engineering materials 310

      Pages: 817-820

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The Biological Properties of a Novel Ethyl Methacrylate Resin.2006

    • Author(s)
      Suzuki, T., et al.
    • Journal Title

      Journal of International Medical Research 34(3)(In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Calcium phosplate deposit on pearl in vitro2004

    • Author(s)
      Tsuruta, S., et al.
    • Journal Title

      Aichi-Gakuin Dent Sci 17(1)

      Pages: 29-32

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 有限要素法によるインプラントの応力解析-ディンプル型とスクリュー型インプラントの応力解析-2004

    • Author(s)
      有元 通敏 他4名
    • Journal Title

      歯材器 23(4)

      Pages: 268-272

    • Related Report
      2004 Annual Research Report
  • [Journal Article] ADSインプラントのイメージベース三次元応力解析2004

    • Author(s)
      有元 通敏
    • Journal Title

      愛院大歯誌 42(4)

      Pages: 509-515

    • Related Report
      2004 Annual Research Report
  • [Journal Article] His topathological Safety Evaluation of Polyethylene Glycol AppliedSubcutaneously in Mice2004

    • Author(s)
      Kawakami, T., et al.
    • Journal Title

      J.Int.Med.Res. 32(1)

      Pages: 66-69

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 新β型チタン合金(Ti-13Ta-29Nb-4.6Zr)の生体親和性に関する病理組織学的研究2004

    • Author(s)
      伊藤 正満 他8名
    • Journal Title

      歯材器 23(1)

      Pages: 21-28

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Biocompatibility of composite membrane consisting of oriented needle-like apatite and biodetradable copoly2004

    • Author(s)
      Watanabe, T., et al.
    • Journal Title

      Dent.Mater.J. 23(4)

      Pages: 609-612

    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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