• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Diagnostic and therapeutic application of checkpoint gene CHFR in oral squamous cell cancer.

Research Project

Project/Area Number 16390597
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionSapporo Medical University

Principal Investigator

TOKINO Takashi  Sapporo Medical University, Cancer Research Inst, Dept Molecular Biology, Professor, 医学部, 教授 (40202197)

Co-Investigator(Kenkyū-buntansha) HIRATSUKA Hiroyoshi  Sapporo Medical University, Professor, 医学部, 教授 (50165180)
KIDO Sachie  Sapporo Medical University, Instructor, 医学部, 助手 (20363690)
田中 信幸  札幌医科大学, 医学部, 助教授 (50163548)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥13,900,000 (Direct Cost: ¥13,900,000)
Fiscal Year 2005: ¥5,300,000 (Direct Cost: ¥5,300,000)
Fiscal Year 2004: ¥8,600,000 (Direct Cost: ¥8,600,000)
KeywordsCancer / Translational Research / Chemosensitivity / Cell Cycle Control / Ubiquitin ligase / ユビキチンリガーゼ / 癌 / 細胞周期 / 有糸分裂 / チェックポイント / 微小管脱重合阻害剤 / 口腔癌 / 感受性診断
Research Abstract

Alterations in the function of cell cycle checkpoints are frequently detected in oral squamous cell carcinomas (OSCCs), and are often associated with the sensitivity of the cancer cells to chemotherapeutic drugs. Recently, a mitotic checkpoint gene, Chfr, was shown to be inactivated by promoter methylation and point mutations in various human tumors. Here we show that the absence of its product, CHFR, is associated with mitotic checkpoint dysfunction, and that cancer cells lacking CHFR are sensitive to microtubule inhibitors. Checkpoint impairment appears to be caused by a prophase defect in this case, as OSCC cells lacking CHFR showed phosphorylation of histone H3 on Ser10 and translocation of cyclin B1 to the nucleus. When CHFR-deficient OSCC cells were treated with a microtubule inhibitor (docetaxel or paclitaxel), significant numbers of apoptotic cells were observed. Moreover, disruption of CHFR using small interfering RNA (siRNA) impaired the mitotic checkpoint, thereby reducing the ability of OSCC cells to arrest at G2/M phase and making them more sensitive to microtubule inhibitors. Our results suggest that CHFR could be a useful molecular target for chemotherapy.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (70 results)

All 2006 2005 2004 Other

All Journal Article (70 results)

  • [Journal Article] Comparative genome analysis identifies the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation.2006

    • Author(s)
      Maruyama R et al.
    • Journal Title

      Cancer Research (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The Ras effector RASSF2 is a novel tumor suppressor gene in human colorectal cancer.2006

    • Author(s)
      Akino K et al.
    • Journal Title

      Gastroenterology 129・1

      Pages: 156-169

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Antiangiogenic potency of BAI1 in vivo : Implications for gene therapy treatment of human glioblastomas.2006

    • Author(s)
      Kang X et al.
    • Journal Title

      Cancer Gene Therapy 13・4

      Pages: 385-392

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Genetic, epigenetic and clinicopathological features of gastric cancers with CpG island methylator phenotype and association to Epstein-Barr virus.2006

    • Author(s)
      Kusano M et al.
    • Journal Title

      Cancer 106・7

      Pages: 1467-1479

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Unique domain functions of p63 isotypes that differentially regulate distinct aspects of epidermal homeostasis.2006

    • Author(s)
      King KE et al.
    • Journal Title

      Carcinogenesis 27・1

      Pages: 53-63

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Epigenetic inactivation of the candidate tumor suppressor gene HOXB13 in human renal cell carcinoma.2006

    • Author(s)
      Okuda H et al.
    • Journal Title

      Oncogene 25・12

      Pages: 1733-1742

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Epigenetic inactivation of TCF2in ovarian cancer and various cancer cell lines.2006

    • Author(s)
      Terasawa K et al.
    • Journal Title

      British J Cancer 94・6

      Pages: 914-921

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Comparative genome analysis identifies the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation.2006

    • Author(s)
      Maruyama R et al.
    • Journal Title

      Cancer Research (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The Ras effector RASSF2 is a novel tumor suppressor gene in human colorectal cancer.2006

    • Author(s)
      Akino K et al.
    • Journal Title

      Gastroenterology 129-1

      Pages: 156-169

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Antiangiogenic potency of BAI1 in vivo : Implications for gene therapy treatment of human glioblastomas.2006

    • Author(s)
      Kang X et al.
    • Journal Title

      Cancer Gene Therapy 13-4

      Pages: 385-392

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Genetic, epigenetic and clinicopathological features of gastric cancers with CpG island methylator phenotype and association to Epstein-Barr virus.2006

    • Author(s)
      Kusano M et al.
    • Journal Title

      Cancer 106-7

      Pages: 1467-1479

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Unique domain functions of p63 isotypes that differentially regulate distinct aspects of epidermal homeostasis.2006

    • Author(s)
      King KE et al.
    • Journal Title

      Oncogene 27-1

      Pages: 53-63

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Epigenetic inactivation of the candidate tumor suppressor gene HOXB13 in human renal cell carcinoma.2006

    • Author(s)
      Okuda H et al.
    • Journal Title

      Oncogene 25-12

      Pages: 1733-1742

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Epigenetic inactivation of TCF2in ovarian cancer and various cancer cell lines.2006

    • Author(s)
      Terasawa K et al.
    • Journal Title

      British J Cancer 94-6

      Pages: 914-921

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Comparative genome analysis identifies the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation.2006

    • Author(s)
      Maruyama et al.
    • Journal Title

      Cancer Research (印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Genetic, epigenetic and clinicopathological features of gastric cancers with CpG island methylator phenotype and association to Epstein-Barr virus.2006

    • Author(s)
      Kusano M et al.
    • Journal Title

      Cancer (印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Unique domain functions of p63 isotypes that differentially regulate distinct aspects of epidermal homeostasis.2006

    • Author(s)
      King KE et al.
    • Journal Title

      Carcinogenesis (印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Epigenetic inactivation of TCF2in ovarian cancer and various cancer cell lines.2006

    • Author(s)
      Terasawa K et al.
    • Journal Title

      British J Cancer (印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Antiangiogenic potency of BAIL in vivo : Implications for gene therapy treatment of human glioblastomas.2006

    • Author(s)
      Kang X et al.
    • Journal Title

      Cancer Gene Therapy (印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Small interfering RNA-induced CHFR silencing sensitizes oral squamous cell cancer cells to microtuble inhibitors.2005

    • Author(s)
      Ogi K et al.
    • Journal Title

      Cancer Biology Therapy 4・7

      Pages: 773-780

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Identification of pigment epithelium derived factor as a direct target of the p53 family member genes.2005

    • Author(s)
      Sasaki Y et al.
    • Journal Title

      Oncogene 24・32

      Pages: 5131-5136

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Aberrant laminin beta3 isoforms downstream of EWS-ETS fusion genes in Ewing family tumors.2005

    • Author(s)
      Irifune H et al.
    • Journal Title

      Cancer Biology Therapy 4・4

      Pages: 449-455

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] A full genome scan for gastric cancer.2005

    • Author(s)
      Aoki M et al.
    • Journal Title

      J Medical Genetics 42・1

      Pages: 83-87

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Id2 protein is selectively upregulated by UVB in primary, but not in immortalized human keratinocytes and inhibits differentiation.2005

    • Author(s)
      Simbulan-Rosenthal CM et al.
    • Journal Title

      Oncogene 24・35

      Pages: 5443-5458

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer.2005

    • Author(s)
      Murai M et al.
    • Journal Title

      Clinical Cancer Research 11・3

      Pages: 1021-1027

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] The role of T-fimbrin in the response to DNA damage : Silencing of T-fimbrin by small interfering RNA sensitizes human liver cancer cells to DNA-damaging agents.2005

    • Author(s)
      Ikeda H et al.
    • Journal Title

      Int J Oncology 27・4

      Pages: 933-940

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Aberrant DNA methylation associated with silencing BNIP3 gene expression in haematopoietic tumours.2005

    • Author(s)
      Murai M et al.
    • Journal Title

      British J Cancer 92・6

      Pages: 1165-1172

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Abnormal beta-catenin expression of cyclin Dl and epidermal growth factor receptor, Ki-67 labeling index, and clinicopathological features.2005

    • Author(s)
      Odajima T et al.
    • Journal Title

      Human Pathology 36・3

      Pages: 234-241

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Tight junction protein MAGI-1 is up-regulated by transfection with connexin 32 in an immortalized mouse hepatic cell line : cDNA micrroarray analysis.2005

    • Author(s)
      Murata M et al.
    • Journal Title

      Cell Tissue Research 319・2

      Pages: 341-347

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Upregulation of BNIP3 by 5-aza-2' -deoxycytidine sensitizes pancreatic cancer cells to hypoxia-mediated cell death.2005

    • Author(s)
      Abe T et al.
    • Journal Title

      J Gastroenterology 40・5

      Pages: 504-510

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Small interfering RNA-induced CHFR silencing sensitizes oral squamous cell cancer cells to microtuble inhibitors.2005

    • Author(s)
      Ogi K et al.
    • Journal Title

      Cancer Biology Therapy 4-7

      Pages: 773-780

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Identification of pigment epithelium derived factor as a direct target of the p53 family member genes.2005

    • Author(s)
      Sasaki Y et al.
    • Journal Title

      Oncogene 24-32

      Pages: 5131-5136

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Aberrant laminin beta3 isoforms downstream of EWS-ETS fusion genes in Ewing family tumors.2005

    • Author(s)
      Irifune H et al.
    • Journal Title

      Cancer Biology Therapy 4-4

      Pages: 449-455

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A full genome scan for gastric cancer.2005

    • Author(s)
      Aoki M et al.
    • Journal Title

      J Medical Genetics 42-1

      Pages: 83-87

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Id2 protein is selectively upregulated by UVB in primary, but not in immortalized human keratinocytes and inhibits differentiation.2005

    • Author(s)
      Simbulan-Rosenthal CM et al.
    • Journal Title

      Oncogene 24-35

      Pages: 5443-5458

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer.2005

    • Author(s)
      Murai M et al.
    • Journal Title

      Clinical Cancer Research 11-3

      Pages: 1021-1027

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The role of T-fimbrin in the response to DNA damage : Silencing of T-fimbrin by small interfering RNA sensitizes human liver cancer cells to DNA-damaging agents.2005

    • Author(s)
      Ikeda H et al.
    • Journal Title

      Int J Oncology 27-4

      Pages: 933-940

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Aberrant DNA methylation associated with silencing BNIP3 gene expression in haematopoietic tumours.2005

    • Author(s)
      Murai M et al.
    • Journal Title

      British J Cancer 92-6

      Pages: 1165-1172

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Abnormal beta-catenin expression of cyclin D1 and epidermal growth factor receptor, Ki-67 labeling index, and clinicopathological features.2005

    • Author(s)
      Odajima T et al.
    • Journal Title

      Human Pathology 36-3

      Pages: 234-241

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Tight junction protein MAGI-1 is up-regulated by transfection with connexin 32 in an immortalized mouse hepatic cell line : cDNA micrroarray analysis.2005

    • Author(s)
      Murata M et al.
    • Journal Title

      Cell Tissue Research 319-2

      Pages: 341-347

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Upregulation of BNIP3 by 5-aza-2'-deoxycytidine sensitizes pancreatic, cancer cells to hypoxia-mediated cell death.2005

    • Author(s)
      Abe T et al.
    • Journal Title

      J Gastroenterology 40-5

      Pages: 504-510

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Small interfering RNA-induced CHFR silencing sensitizes oral aquamous cell cancer cells to microtuble inhibitors.2005

    • Author(s)
      Ogi K et al.
    • Journal Title

      Cancer Biology Therapy 4・7

      Pages: 773-780

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Abnormal beta-catenin expression of cyclin D1 and epidermal growth factor receptor, Ki-67 labeling index, and clinicopathological features.2005

    • Author(s)
      Odajima T et al.
    • Journal Title

      Human Pathology 36・3

      Pages: 234-241

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Upregulation of BNIP3 by 5-aza-2'-deoxycytidine sensitizes pancreatic cancer cells to hypoxia-mediated cell death.2005

    • Author(s)
      Abe T et al.
    • Journal Title

      J Gastroenterology 40・5

      Pages: 504-510

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A full genome scan for gastric cancer.2005

    • Author(s)
      Aoki M
    • Journal Title

      J Medical Genetics 42・1

      Pages: 83-87

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Tight junction proteinMAGi-1 is up-regulated by tranfection with connexin 32 in an immortalized mouse hepatic cell line : cDNA microarray analysis.2005

    • Author(s)
      Murata M
    • Journal Title

      Cell Tissue Research 319・2

      Pages: 341-347

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Identification of SCN3B as a novel p53-inducible proapototic gene.2004

    • Author(s)
      Adachi K et al.
    • Journal Title

      Oncogene 23・47

      Pages: 7791-7798

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer.2004

    • Author(s)
      Suzuki H et al.
    • Journal Title

      Nature Genetics 36・4

      Pages: 417-422

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Dual roles of p53 in DNA binding.2004

    • Author(s)
      Tokino T
    • Journal Title

      Cancer Biology Therapy 3・12

      Pages: 1322-1323

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Epigenetic inactivation of classII transactivator (CIITA) is associated with the absence of interferon-gamma-induced HLA-DR expression in colorectal and gastric cancer cells.2004

    • Author(s)
      Satoh A et al.
    • Journal Title

      Oncogene 23・55

      Pages: 8876-8886

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Epigenetic inactivation of TMS1/ASC in ovarian cancer.2004

    • Author(s)
      Terasawa K et al.
    • Journal Title

      Clinical Cancer Research 10・6

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Inactivation of class II transactivator by DNA methylation and histone deacetylation associated with absence of HLA-DR induction by interferon gamma in hematopoietic tumor cells.2004

    • Author(s)
      Morimoto Y et al.
    • Journal Title

      British J Cancer 90・4

      Pages: 844-852

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Regulation of MHC class II expression in glioma cells by class II transactivator (CIITA).2004

    • Author(s)
      Takamura Y et al.
    • Journal Title

      Glia 45・4

      Pages: 392-405

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Aberrant methylation and histone deacetylation associated with silencing of SLC5A8 in gastric cancer.2004

    • Author(s)
      Ueno M et al.
    • Journal Title

      Tumor Biology 25・3

      Pages: 134-140

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Identification of SCN3B as a novel p53-inducible proapototic gene.2004

    • Author(s)
      Adachi K et al.
    • Journal Title

      Oncogene 23-47

      Pages: 7791-7798

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer.2004

    • Author(s)
      Suzuki H et al.
    • Journal Title

      Nature Genetics 36-4

      Pages: 417-422

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Dual roles of p53 in DNA binding.2004

    • Author(s)
      Tokino T et al.
    • Journal Title

      Cancer Biology Therapy 3-12

      Pages: 1322-1323

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Epigenetic inactivation of classII transactivator (CIITA) is associated with the absence of interferon-gamma-induced HLA-DR expression in colorectal and gastric cancer cells.2004

    • Author(s)
      Satoh A et al.
    • Journal Title

      Oncogene 23-55

      Pages: 8876-8886

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Epigenetic inactivation of TMS1/ASC in ovarian cancer.2004

    • Author(s)
      Terasawa K et al.
    • Journal Title

      Clinical Cancer Research 10-6

      Pages: 2000-2006

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Inactivation of class II transactivator by DNA methylation and histone deacetylation associated with absence of HLA-DR induction by interferon gamma in hematopoietic tumor cells.2004

    • Author(s)
      Morimoto Y et al.
    • Journal Title

      British J Cancer 90-4

      Pages: 844-852

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Inactivation of class II transactivayor by DNA methylation and histone deacetylation associated with absence of HLA-DR induction by interferon gamma in hematopoietic tumor cells.2004

    • Author(s)
      Morimoto Y
    • Journal Title

      British J Cancer 90・4

      Pages: 844-852

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Regulation of MHC class II expression in glioma cells by class II transactivator (CIITA).2004

    • Author(s)
      Takamura Y
    • Journal Title

      Glia 45・4

      Pages: 392-405

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Epigenetic inactivation of TMS1/ASC in ovarian cancer.2004

    • Author(s)
      Terasawa K
    • Journal Title

      Clinical Cancer Research 10・6

      Pages: 2000-2006

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer.2004

    • Author(s)
      Suzuki H
    • Journal Title

      Nature Genetics 36・4

      Pages: 417-422

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Aberrant methylation and histone deacetylation associated with silencing of SLC5A8 in gastric cancer.2004

    • Author(s)
      Ueno M
    • Journal Title

      Tumor Biology 25・3

      Pages: 134-140

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Identification of SCN3B as a novel p53-inducible proapoptotic gene.2004

    • Author(s)
      Adachi K
    • Journal Title

      Oncogene 23・47

      Pages: 7791-7798

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Epigenetic inactivation of class II transactivator (CIITA) is associated with the absence of interferon-g-induced HLA-DR expression in colorectal and gastric cancer cells.2004

    • Author(s)
      Satoh A
    • Journal Title

      Oncogene 23・55

      Pages: 8876-8886

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Dual roles of p53 in DNA binding.

    • Author(s)
      Tokino T
    • Journal Title

      Cancer Biology & Therapy (発表予定)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer.

    • Author(s)
      Murai M
    • Journal Title

      Clinical Cancer Research (発表予定)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Aberrant laminin b3 isoforms downstream of EWS-ETS fusion genes in Ewing family tumors.

    • Author(s)
      Irifune H
    • Journal Title

      Cancer Biology & Therapy (発表予定)

    • Related Report
      2004 Annual Research Report

URL: 

Published: 2004-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi