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Analysis of periodontal tissue remodeling mechanism induced by mechanical stress and the regulation by gene transfer

Research Project

Project/Area Number 16390602
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthodontic/Pediatric dentistry
Research InstitutionTohoku University

Principal Investigator

CHIBA Mirei  Tohoku University, Tohoku University, Graduate School of Dentistry, Associate Professor (10236820)

Co-Investigator(Kenkyū-buntansha) IGARASHI Kaoru  Tohoku University, Graduate School of Dentistry, Professor (70202851)
KANZAKI Hiroyuki  Tohoku University Hospital, 病院, Assistant Professor (30333826)
Project Period (FY) 2004 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥14,960,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥660,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2006: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 2005: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 2004: ¥7,900,000 (Direct Cost: ¥7,900,000)
KeywordsMechanical stress / Periodontal tissue / Gene transfer / Orthodontic tooth movement / Remodeling / Periodontal ligament cells / Osteoblasts / Osteoclasts / リモデリング / エレクトロポレーション / Bone Morphogenetic Protein / 超音波 / 血管新生因子 / アポトーシス / 骨吸収 / 骨形成 / OPG / RANKL / BMP-4
Research Abstract

The purpose of this research is to analyze the expression of molecules induced by the mechanical stress, and then to select the functional bone remodeling regulatory molecules, and to transfer these genes into the periodontal tissue, and finally, to control the local bone remodeling mechanism.
1. The analysis of molecules induced by mechanical stress in the cells of the periodontal tissue
(1) Both the osteoblasts differentiation-regulating factor and the osteoclast differentiation-regulating factor produced from the periodontal ligament (PDL) cells: Soluble factor produced from PDL cells stimulated by cyclic tension force inhibited osteoblast differentiation, suppressing the expression of transcription factor, osterix and runx-2. Osteoprotegerin (OPG) was also produced by PDL cells, and on the other hand, inhibited the osteoclast formation.
(2) The differences of the response to continuous compression force between PDL cells and the osteoblasts: The PDL cells were resistance to the compre … More ssion force, and promoted the production of the angiogenesis factor corresponding to the compression force. On the other hand, osteoblasts were caused apoptosis by activation of caspase-3 via caspase-8 signaling pathway.
2. Development of appropriate in vivo delivery system of in vivo gene transfer to periodontal tissue and functional analysis
(1) Receptor activator of NF- r B ligand (RANKL) and the OPG gene transfer by the HVJ-envelop vector method: RANKL gene transfer promoted the experimental tooth movement (ETM). Moreover the OPG gene transfers inhibited ETM and relapse after ETM by regulating the osteoclast formation.
(2) Bone morphogenetic protein (BMP) -4-gene transfer by the in vivo electroporation method: The alveolar bone density increased by the BMP-4 gene transfer, and the relapse after ETM inhibited.
(3) The gene transfer by the ultrasound using nanobubbles together: Using the nanobubbles together, high efficiency and transient expression were observed in the experiment targeting to PDL cells in vitro, and to periodontal tissue in vivo. Less

Report

(5 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (74 results)

All 2008 2007 2006 2005 2004

All Journal Article (46 results) (of which Peer Reviewed: 14 results) Presentation (24 results) Book (4 results)

  • [Journal Article] Periodontal tissue activation by vibration: intermittent stimulation by resonance vibration accelerates experimental tooth movement in rats2008

    • Author(s)
      Nishimura M, Chiba M, Ohashi T, Sato M, Shimizu Y, Igarashi K, Mitani H.
    • Journal Title

      Am J Orthod Dentofacial Orthop 133(4)

      Pages: 572-583

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Periodontal tissue activation by vibration: intermittent stimulation by resonance vibration accelerates2008

    • Author(s)
      Nishimura M, Chiba M, Ohashi T, Sato M, Shimizu Y, Igarashi K, Mitani H.
    • Journal Title

      Am J Orthod Dentofacial Orthop. 133(4)

      Pages: 572-583

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Periodontal tissue activation by vibration: Intermittent stimulation by resonance vibration accelerates experimental tooth movement in rats2008

    • Author(s)
      Makoto Nishimura, Mirei Chiba, Toshiro Ohashi, Masaaki Sato, Yoshiyuki Shimizu, Kaoru Igarashi, Hideo Mitani
    • Journal Title

      American Journal of Orthodontics & Dentofacial Orthopedics 133

      Pages: 572-583

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Local osteoprotegerin gene transfer to periodontal tissue inhibits lipopolysaccharide-induced alveolar bone resorption.2008

    • Author(s)
      Chen R, Kanzaki H, Chiba M, Nishimura M, Kanzaki R, Igarashi K.
    • Journal Title

      J Periodontal Res. 43

      Pages: 237-245

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ナノバブルと超音波を用いた歯周組織への遺伝子導入2008

    • Author(s)
      陳鋭, 千葉美麗, 堀江佐知子, 渡邊夕紀子, 森士朗, 五十嵐薫, 小玉哲也
    • Journal Title

      日本機械学会第20回バイオエンジニアリング講演論文集 07-49

      Pages: 79-80

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Local osteoprotegerin gene transfer to periodontal tissue inhibits lipopolysaccharide-induced alveolar bone resorption.2007

    • Author(s)
      Chen R, Kanzaki H, Chiba M, Nishimura M, Kanzaki R, Igarashi K.
    • Journal Title

      J Periodontal Res 43(2):

      Pages: 237-245

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Osteoblast apoptosis by compressive force and its signaling pathway.2007

    • Author(s)
      Chiba M, Goga Y, Sato A, Igarashi K
    • Journal Title

      Interface Oral Health Science 2007

      Pages: 189-190

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Periodontal tissue activation by resonance vibration2007

    • Author(s)
      Nishimura M, Chiba M, Ohashi T, Sato M, Igarashi K
    • Journal Title

      Interface Oral Health Science 2007.

      Pages: 185-186

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Local osteoprotegerin gene transfer to periodontal tissue inhibits lipopolysaccharide-induced alveolar bone resoption2007

    • Author(s)
      Chen R, Kanzaki H, Chiba M, Nishimura M, Kanzaki R, Igarashi K.
    • Journal Title

      J Periodontal Res 43(2)

      Pages: 237-245

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Osteoblast apoptosis by compressive force and its signaling pathway2007

    • Author(s)
      Chiba M, Goga Y, Sato A, Igarashi K
    • Journal Title

      Interface Oral Health Science 2007

      Pages: 189-190

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] Periodontal tissue activation by resonance vibration2007

    • Author(s)
      Nishimura M, Chiba M, Ohashi T, Sato M, Igarashi K
    • Journal Title

      Interface Oral Health Science 2007

      Pages: 185-186

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] Periodontal tissue activation by vibration; intermittent stimulation by resonance vibration accelerates experimental tooth movement in rats2007

    • Author(s)
      Nishimura M
    • Journal Title

      American Journal of Orthodontics & Dentofacial Orthopedics (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Osteoblast apoptosis by compressive force and its signaling pathway2007

    • Author(s)
      M.Chibal, Y.Goga, A.Sato, K.Igarashi
    • Journal Title

      Interface Oral Health Science 2007 (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Periodontal tissue activation by resonance vibration2007

    • Author(s)
      M.Nishimura, M.Chiba, T.Ohashi, M.Sato, K.Igarashi
    • Journal Title

      Interface Oral Health Science 2007 (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Clodronate inhibits PGE(2) production in compressed periodontal ligament cells.2006

    • Author(s)
      Liu L, Igarashi K, Kanzaki H, Chiba M, Shinoda H, Mitani H.
    • Journal Title

      J Dent Res 85(8):

      Pages: 757-760

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Cyclical tensile force on periodontal ligament cells inhibits osteoclastogenesis through OPG induction2006

    • Author(s)
      Kanzaki H, Chiba M, Sato A, Miyagawa A, Arai K, Nukatsuka S, Mitani H.
    • Journal Title

      J Dent Res 85(5):

      Pages: 457-462

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Compressive force induces osteoblast apoptosis via caspase-8.2006

    • Author(s)
      Goga Y, ChibaM, Shimizu Y, Mitani H.
    • Journal Title

      J Dent Res. 85(3

      Pages: 240-244

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Local RANHL gene transfer to the periodontal tissue accelerates orthodontic tooth movement.2006

    • Author(s)
      Kanzaki H, Chiba M, Arai K, Takahashi I, Haruyama N, Nishimura M, Mitani H.
    • Journal Title

      Gene Ther. ;13(8):

      Pages: 678-685

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Clodronate inhibits PGE(2) production in compressed periodontal liament cells2006

    • Author(s)
      Liu L, Igarashi K, Kanzaki H, Chiba M, Shinoda H, Mitani H.
    • Journal Title

      J Dent Res 85(8)

      Pages: 757-760

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cyclical tensile for ce on periodontal ligameng cells inhibits osteoclastogenesis through OPG induction2006

    • Author(s)
      Kanzaki H, Chiba M, Sato A, Miyagawa A, Arai K, Nukatsuka S, Mitani H.
    • Journal Title

      J Dent Res 85(5)

      Pages: 457-462

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Compressive force induces osteoblast apoptosis via caspase-82006

    • Author(s)
      Goga Y, Chiba M, Shimizu Y, Mitani H.
    • Journal Title

      J Dent Res 85(3)

      Pages: 240-244

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Local RANKL gene transfer to the periodontal tissue accelerates orthodontic tooth movement2006

    • Author(s)
      Kanzaki H, Chiba M, Arai K, Takahashi I, Haruyama N, Nishimura M, Mitani H.
    • Journal Title

      Gene Ther 13(8)

      Pages: 678-685

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Local RANKL gene transfer to the periodontal tissue accelerates orthodontic tooth movement.2006

    • Author(s)
      Kanzaki H, Chiba M, Arai K, Takahashi I, Haruyama N, Nishimura M, Mitani H
    • Journal Title

      Gene Ther 13・8

      Pages: 678-685

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Compressive force induces osteoblast apoptosis via caspase-8.2006

    • Author(s)
      Goga Y, Chiba M, Shimizu Y, Mitani H
    • Journal Title

      J Dent Res 85・3

      Pages: 240-244

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cyclical tensile force on periodontal ligament cells inhibits osteoclastogenesis through OPG induction.2006

    • Author(s)
      Kanzaki H, Chiba M, Sato A, Miyagawa A, Arai K, Nukatsuka S, Mitani H
    • Journal Title

      J Dent Res 85・5

      Pages: 457-462

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Clodronate inhibits PGE(2) production in compressed periodontal ligament cells.2006

    • Author(s)
      Liu L, Igarashi K, Kanzaki H, Chiba M, Shinoda H, Mitani H
    • Journal Title

      J Dent Res 85・8

      Pages: 757-760

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 超音波による歯根膜細胞への遺伝子導入の試み2006

    • Author(s)
      山崎 仁, 千葉美麗, 佐藤綾, 五十嵐薫, 小玉哲也
    • Journal Title

      日本実験力学会講演論文集 6

      Pages: 148-150

    • Related Report
      2006 Annual Research Report
  • [Journal Article] メカニカルストレス受容歯根膜細胞による破骨細胞分化誘導制御2006

    • Author(s)
      千葉美麗, 菅崎弘幸, 松本千登勢, 糖塚世毅
    • Journal Title

      日本実験力学会講演論文集 6

      Pages: 151-153

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Local RANKL gene transfer to the periodontal tissue accelerates orthodontic tooth movement2006

    • Author(s)
      Kanzaki H
    • Journal Title

      Gene Therapy 13・8

      Pages: 678-685

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Tension to PDL inhibited OC-genesis through OPG induction2006

    • Author(s)
      Kanzaki H
    • Journal Title

      Journal of Dental Research (印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Periodontal tissue activation by vibration ; intermittent stimulation by resonance vibration accelerates experimental tooth movement in rats2006

    • Author(s)
      Nishimura M
    • Journal Title

      American Journal of Orthodontics & Dentofacial Orthopedics (印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] メカニカルストレス受容歯根膜細胞による破骨細胞分化誘導制御2006

    • Author(s)
      千葉美麗
    • Journal Title

      日本実験力学会講演論文集 6

      Pages: 151-153

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 超音波による歯根膜細胞への遺伝子導入の試み2006

    • Author(s)
      山崎 仁
    • Journal Title

      日本実験力学会講演論文集 6

      Pages: 148-150

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Compressive Force Induces Osteoblast Apoptosis via Caspase-82005

    • Author(s)
      Goga Y
    • Journal Title

      Journal of Dental Research 85・3

      Pages: 240-244

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Local OPG gene transfer to periodontal tissue inhibits orthodontic tooth movement.2004

    • Author(s)
      Kanzaki H, Chiba M, Takahashi I, Haruyama N, Nishimura M, Mitani H.
    • Journal Title

      J Dent Res 83(12):

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Cytoskeletal changes and the system of regulation of alkaline phosphatase activity in human periodontal ligament cells induced by mechanical stress.2004

    • Author(s)
      Chiba M, Mitani H
    • Journal Title

      Cell Biochem Funct. 22(4):

      Pages: 249-256

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Establishment of Periodontal Ligament Cell Lines from Temperature-Sensitive Simian Virus 40 Large T-antigen Transgenic Rats.2004

    • Author(s)
      Kubota M, Chiba M, Obinata M, Ueda S, Mitani H
    • Journal Title

      Cytotechnology 44

      Pages: 55-65

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Local OPG gene transfer to periodontal tissue inhibits orthodontic tooth movement2004

    • Author(s)
      Kanzaki H, Chiba M, Takahashi I, Haruyama N, Nishimura M, Mitani H.
    • Journal Title

      J Dent res 83(12)

      Pages: 920-925

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cytoskeletal changes and the system of regulation of alkaline phosphatase activity in human periodontal ligament cells induced by mechanical stress2004

    • Author(s)
      Chiba M, Mitani H.
    • Journal Title

      Cell Biochem Funct 22(4)

      Pages: 249-256

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Establishment of Periodontal Ligament Cell Lines from Temperature-Sensitive Simian Virus 40 Large T-antigen Transgenic Rats2004

    • Author(s)
      Kubota M, chiba M, Obinata M, ueda S, Mitani H
    • Journal Title

      Cytotechnology 44

      Pages: 55-65

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Establishment of periodontal ligament cell lines from temperature-sensitive simian virus 40 large T-antigen transgenic rats2004

    • Author(s)
      Mamoru Kubota
    • Journal Title

      Cytotechnology 44

      Pages: 55-65

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Cytoskeletal changes and the system of regulation of alkaline phosphatase activity in human periodontal ligament cells induced by mechanical stress2004

    • Author(s)
      Mirei Chiba
    • Journal Title

      Cell Biochemistry and Function 22

      Pages: 249-256

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Local OPG gene transfer to periodontal tissue inhibits orthodontic tooth movement2004

    • Author(s)
      H.Kanzaki
    • Journal Title

      Journal of Dental Research 83

      Pages: 920-925

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 周期的伸展刺激受容により歯根膜細胞から産生される破骨細胞形成抑制因子の解析2004

    • Author(s)
      糠塚 世毅
    • Journal Title

      日本実験力学会講演論文集 4-2

      Pages: 188-189

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 機械的圧縮力による骨芽細胞の細胞死2004

    • Author(s)
      五賀 優子
    • Journal Title

      日本実験力学会講演論文集 4-2

      Pages: 190-192

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 共振周波数を用いた振動刺激が歯周組織に与える影響2004

    • Author(s)
      千葉 美麗
    • Journal Title

      日本実験力学会講演論文集 4-2

      Pages: 193-196

    • Related Report
      2004 Annual Research Report
  • [Presentation] ナノバブルと超音波を用いた歯周組織への遺伝子導入2008

    • Author(s)
      陳鋭, 千葉美麗, 堀江佐知子, 渡邊夕紀子, 森士朗, 五十嵐薫, 小玉哲也
    • Organizer
      日本機械学会第20回バイオエンジニアリング講演会
    • Place of Presentation
      芝浦工業大学豊洲キャンパス
    • Related Report
      2007 Annual Research Report
  • [Presentation] 歯周組織のリモデリングを制御する歯根膜細胞のバイオメカニクス2007

    • Author(s)
      千葉美麗, 五賀優子, 菅崎弘幸, 山本照子
    • Organizer
      第46回日本生体医工学会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2007-04-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] New Trial of Ultrasound Gene Transfer to Periodontal Ligament Cells2007

    • Author(s)
      M. CHIBA, A. SATO, H. YAMAZAKI, K. IGARASHI, and T. KODAMA
    • Organizer
      The IADR/AADR/CADR 85th General Session and Exhibition
    • Place of Presentation
      New Orleans, LA, USA.
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The inhibition of osteoblast differentiation by periodontal ligament cells 1940 The inhibition of osteoblast differentiation by periodontal ligament cells2007

    • Author(s)
      A. SATO, M. CHIBA, M. KUBOTA, and K. IGARASHI
    • Organizer
      The IADR/AADR/CADR 85th General Session and Exhibition
    • Place of Presentation
      New Orleans, LA, USA.
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] LPS Induces Alveolar Bone Resorption by Stimulating RANKL Expression2007

    • Author(s)
      R. CHEN, M. CHIBA, H. KANZAKI, and K. IGARASHI
    • Organizer
      The IADR/AADR/CADR 85th General Session and Exhibition
    • Place of Presentation
      New Orleans, LA, USA.
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Compression force induces angiogenic factor in human periodontal ligament fibroblasts2007

    • Author(s)
      A. MIYAGAWA, M. CHIBA, and K. IGARASHI
    • Organizer
      The IADR/AADR/CADR 85th General Session and Exhibition
    • Place of Presentation
      New Orleans, LA, USA.
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] New Trial of Ultrasound Gene Transfer to Periodontal Ligament Cells2007

    • Author(s)
      M. CHIBA, A. SATO, H. TAMAZAKI, K. IGARASHI, and T. KODAMA
    • Organizer
      The IADR/AADR/CADR 85th General Session and Exhibition
    • Place of Presentation
      New Orleans, LA, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The inhibition of osteoblast differentiation by periodontal ligament cells 1940 The inhibition of osteoblast differentiation by periodontal ligament cells2007

    • Author(s)
      A. SATO, M. CHIBA, M. KUBOTA, and K. IGARASHI
    • Organizer
      The IADR/AADR/CADR 85th General Session and Exhibition
    • Place of Presentation
      New Orleans, LA, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] LPS Induces Alveolar Bone Resorption by Stimulating RANKL Expression2007

    • Author(s)
      R. CHEN, M. CHIBA, H. KANZAKI, and K. IGARASHI
    • Organizer
      The IADR/AADR/CADR 85th General Session and Exhibition
    • Place of Presentation
      New Orleans, LA, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Compression force induces angiogenic factor in human periodontal ligament fibroblasts2007

    • Author(s)
      A. MIYAGAWA, M. CHIBA, and K. IGARASHI
    • Organizer
      The IADR/AADR/CADR 85th General Session and Exhibition
    • Place of Presentation
      New Orleans, LA, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] TACE regulate inert-osteoclastogenesis in tensile-side of orthodontic-tooth-movement by RANKL-modification2006

    • Author(s)
      H. KANZAKI, M. CHIBA, and K. ARAI
    • Organizer
      The IADR 84th General Session & Exhibition
    • Place of Presentation
      Brisbane, Australia
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Retentive effects of local OPG-gene transfer on tooth movement2006

    • Author(s)
      K. ARAI, KANZAKI, and M. CHIBA
    • Organizer
      The IADR 84th General Session & Exhibition
    • Place of Presentation
      Brisbane, Australia
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] TACE regulated inert-osteoclastogenesis in tensile-side of orthodontic-tooth-movement by RANKL-modification2006

    • Author(s)
      H. KANZAKI, M. CHIBA, and K. ARAI
    • Organizer
      The IADR General Session & Exhibition
    • Place of Presentation
      Brisbane, Australia
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Retentive effects of local OPG-gene transfer on tooth movement2006

    • Author(s)
      K. ARAI, KANZAKI, and M. CHIBA
    • Organizer
      The IADR General Session & Exhibition
    • Place of Presentation
      Brisbane, Australia
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] In vivo site-specific gene transfer targeting periodontal ligament2005

    • Author(s)
      M. CHIBA, S. TSUCHIYA, and H. KANZAKI
    • Organizer
      The IADR/AADR/CADR 83rd General Session & Exhibition
    • Place of Presentation
      Baltimore, MD, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mechanically stimulated periodontal ligament cells inhibit osteoclastogenesis via soluble factor (s)2005

    • Author(s)
      M. CHIBA, S. NUKATSUKA and H. KANZAKI
    • Organizer
      The IADR/AADR/CADR 83rd General Session & Exhibition
    • Place of Presentation
      Baltimore, MD, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] BMP-4 gene transfer into rat periodontium using in vivo electroporation2005

    • Author(s)
      M. CHIBA, and S. TSUCHIYA
    • Organizer
      The IADR/AADR/CADR 83rd General Session & Exhibition
    • Place of Presentation
      Baltimore, MD, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] RANKL-sheddase Increased by Tension but not by Compression in PDL-cells2005

    • Author(s)
      H. KANZAKI, M. CHIBA, and K. IGARASHI
    • Organizer
      The LADR/AADR/CADR 83rd General Session & Exhibition
    • Place of Presentation
      Baltimore, MD, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Continuous Compressive Force induces Osteoblast Apoptosis but not PDL Cells2005

    • Author(s)
      Y. GOGA, and M. CHIBA
    • Organizer
      The IADR/AADR/CADR 83rd General Session & Exhibition
    • Place of Presentation
      Baltimore, MD, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] In vivo site-specific gene transfer targeting periodontal ligament2005

    • Author(s)
      M. CHIBA, S. TSUCHIYA, and H. KANZAKI
    • Organizer
      The IADR/AADR/CADR 83rd General Session
    • Place of Presentation
      Baltimore, MD, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mechanically stimulated periodontal ligament cells inhibit osteoclastogenesis via soluble factor(s)2005

    • Author(s)
      M. CHIBA, S. NUKATSUKA and H. KANZAKI
    • Organizer
      The IADR/AADR/CADR 83rd General Session
    • Place of Presentation
      Baltimore, MD, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] BMP-4 gene transfer into rat periodontium using in vivo electroporation2005

    • Author(s)
      M. CHIBA, and S. TSUCHIYA
    • Organizer
      The IADR/AADR/CADR 83rd General Session
    • Place of Presentation
      Baltmore, MD, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] RANKL-sheddase Increased by Tension but not by Compression in PDL-cells2005

    • Author(s)
      H. KANZAKI, M. CHIBA, and K. IGARASHI
    • Organizer
      The IADR/AADR/CADR 83rd General Session
    • Place of Presentation
      Baltimore, MD, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Continuous Compressive Force induces Osteoblast Apoptosis but not PDL Cells2005

    • Author(s)
      Y. GOGA, and M. CHIBA
    • Organizer
      The IADR/AADR/CADR 83rd General Session
    • Place of Presentation
      Baltimore, MD, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 15章 新たな歯の移動のコントロール方法、3)歯根膜細胞への遺伝子導入によるアプローチ、『歯の移動のバイオメカニクス』下野正基, 前田健康, 溝口 到編集2006

    • Author(s)
      千葉美麗
    • Total Pages
      296
    • Publisher
      医歯薬出版
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Clinical Biomechanics on Tooth Movement-Dynamism of Bone and Periodontal Ligament-, Chapter 15 Gene Transfer into Periodontal Ligament Cells: New approach to regulate orthodontic tooth movement. (Edited by Masaki SHIMONO, et. al.)2006

    • Author(s)
      Mirei CHIBA
    • Total Pages
      296
    • Publisher
      Ishiyaku Publishers Inc.
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 歯の移動のバイオメカニクス骨と歯根膜のダイナミズム2006

    • Author(s)
      千葉美麗
    • Total Pages
      296
    • Publisher
      医歯薬出版
    • Related Report
      2006 Annual Research Report
  • [Book] 臨床家のための歯の移動の生物学2006

    • Author(s)
      千葉美麗
    • Publisher
      医歯薬出版(印刷中)
    • Related Report
      2005 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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