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Analysis of Molecular and Biological Basis of Systemic Effects Provoked by Periodontal Diseases

Research Project

Project/Area Number 16390611
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Periodontal dentistry
Research InstitutionTohoku university

Principal Investigator

SHIMAUCHI Hidetoshi  Tohoku University, Graduate School of Dentistry, Professor, 大学院歯学研究科, 教授 (70187425)

Co-Investigator(Kenkyū-buntansha) KANAYA Sousuke  Tohoku University, Hospital, Dentist, 病院・医員 (80375097)
ITAGAKI Yumi  Tohoku University, Graduate School of Dentistry, Assistant professor, 大学院歯学研究科, 助手 (10223067)
SUGAWARA Shunji  Tohoku University, Graduate School of Dentistry, Professor, 大学院歯学研究科, 教授 (10241639)
TAKAHASHI Nobuhiro  Tohoku University, Graduate School of Dentistry, Professor, 大学院歯学研究科, 教授 (60183852)
SHOJI Kanako  Tohoku University, Graduate School of Dentistry, Assistant professor, 大学院歯学研究科, 助手 (90302158)
根本 英二  東北大学, 大学院・歯学研究科, 助手 (40292221)
Project Period (FY) 2004 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥14,400,000 (Direct Cost: ¥14,400,000)
Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2005: ¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2004: ¥9,700,000 (Direct Cost: ¥9,700,000)
Keywordsperiodontitis / systemic diseases / metabolic syndrome / Porphyromonas gingivalis / immune escape / 全疫エスケープ / アディポネクチン / 血糖値 / TNF-α / TLR2 / 樹状細胞 / 実験的歯周炎モデル / P.gingivalis
Research Abstract

The purpose of this study is to explore the unidentified "missing link" to connect the relationship between periodontal and systemic diseases by molecular biological approaches. For this purpose, we focused on the most potent pathogen of chronic periodontitis, Porphyromonas gingivalis and its components, and analyzed the molecular basis of exerting virulence of this bacterium on both periodontal lesions and bodies in vivo and in vitro. Using in vivo animal models, we investigated a series of studies clarifying ; 1)the role of P.gingivalis infection on hyperlipidemia in periodontitis patients ; 2)the effect of P.gingivalis virulence factors on production of adipocytokines from adipose tissues ; 3)the molecular effects of type 2 diabetes on the healing process of periodontium. First, our in vitro study revealed that P.gingivalis LPS and fimbriae preferentially induced a unique dendritic cell subset with a weak immunostimulatory activity via TLR2-mediated signaling, finally contributing t … More o the immune escape of this bacterium in the periodontal lesion. Furthermore, in vivo studies indicated that infection of P.gingivalis is essential for up-regulation of serum triglycerides and its LPS down-regulated the serum level of adiponectin, suggesting P.gingivalis could exert its virulence after invasion into the systemic circulation. The concept of metabolic syndrome (MetS) has been evolving, that is a clustering of simple clinical measures including waist circumferences, blood pressure, triglycerides, high-density lipoproteins and glucose. This clustering appears depend on two major factors: excess body fat and metabolic susceptibility. Taken our results into this concept, invaded P.gingivalis may work as a MetS risk factor in periodontitis patients via down-regulating the serum adiponectin level. The increased risk of MetS possibly started the sequential of "Metaboic Domino" that increasing the susceptibility to diabetes and coronary heart diseases. Diabetes can delay the healing process of periodontally diseased tissue that may increase the chance of P.gigivalis invasion. In conclusion, P.gingivalis may have an adaptation system by dealing with the local immune defense that finally contributes to systemic-periodontal connection. Less

Report

(4 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (10 results)

All 2007 2006 2005 2004

All Journal Article (7 results) Book (3 results)

  • [Journal Article] Implication of Immune Interactions for the Bacterial Virulence : Is Porphyromonas gingivalis an "Invader" or "Stealth" in the Periodontal Lesion?2007

    • Author(s)
      Shimauchi H, Ogawa T
    • Journal Title

      Interface Oral Health Science 2007 (Makoto Watanabe, Haruhiko Takada, Nobuhiro Takahashi eds.)(Springer) (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Porphyromonas gingivalis lipopolysaccharides がラット血中のアデイポカイン並びに中性脂肪濃度に及ぼす影響の検討2006

    • Author(s)
      片岡 由佳
    • Journal Title

      東北大学歯学雑誌 25・1

      Pages: 19-29

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effect of lipopolysaccharides from Porphyromonas gingivalis on serum adiponectin and triglycerides levels in rats.2006

    • Author(s)
      Yuka Kikuchi
    • Journal Title

      Tohoku Univ Dent.J. 25

      Pages: 19-29

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Porphyromonas gingivalis lipopolysaccharidesがラット血中のアデイポカイン並びに中性脂肪濃度に及ぼす影響の検討2006

    • Author(s)
      片岡 由佳
    • Journal Title

      東北大学歯学雑誌 25・1

      Pages: 19-26

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Porphyromonas gingivalis fimbriae induce CD14^+CD16^+ dendritic cell phenotype via TLR2.2005

    • Author(s)
      Kanaya S, Nemoto E, Ogawa T, Minamibuchi M, Honda T, Shimauchi H
    • Journal Title

      International Congress Series 1284 International Oral Health Science (Makoto Watanabe, Nobuhiro Takahashi and Haruhiko Takada eds.)(Elsevier)

      Pages: 169-174

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Porphyromonas gingivalis fimbriae induce CD14^+CD16^+ dendritic cell phenotype via TLR22005

    • Author(s)
      Kanaya S, Nemoto E, Ogawa T, Minamibuchi M, Honda T, Shimauchi H
    • Journal Title

      International Congress Series Oral Health Science 1284

      Pages: 169-174

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Porphyromonas gingivalisによるsystemic effects2004

    • Author(s)
      菊池由佳, 板垣由美, 島内英俊
    • Journal Title

      日本歯科保存学雑誌 47・特別号

      Pages: 45-45

    • Related Report
      2004 Annual Research Report
  • [Book] mplication of Immune Interactions for the Bacterial Virulence : Is Porphyromonas gingivalis an "Invader" or "Stealth" in the Periodontal Lesion? /In Interface Oral Health Science 20072007

    • Author(s)
      Shimauchi H, Ogawa T
    • Publisher
      Springer(印刷中)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] Implication of Immune Interactions for the Bacterial Virulence : Is Porphyromonas gingivalis an "Invader" or "Stealth" in the Periodontal Lesion? In Interface Oral health Science 2007 (Makoto Watanabe, Haruhiko Takada, Nobuhiro Takahashi eds.)2007

    • Author(s)
      Shimauchi H, Ogawa T
    • Publisher
      Springer(350予定)
    • Related Report
      2006 Annual Research Report
  • [Book] Porphyromonas gingivalis fimbriae induce CD14^+CD16^+dendritic cell phenotype via TLR2, In International Congress Series 1284 International Oral Health Science2005

    • Author(s)
      Kanaya S, Nemoto E, Ogawa T et al.
    • Total Pages
      300
    • Publisher
      Elsevier
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary

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Published: 2004-04-01   Modified: 2016-04-21  

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