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Development of periodontal custom made therapy based on gene polymorphisms

Research Project

Project/Area Number 16390612
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Periodontal dentistry
Research InstitutionNiigata University

Principal Investigator

HIROMASA Yoshie  Niigata University, Institute of Medicine and Dentistry, Professor, 医歯学系, 教授 (20143787)

Co-Investigator(Kenkyū-buntansha) NARITA Ichiei  Niigata University, Institute of Medicine and Dentistry, Associate Professor, 医歯学系, 助教授 (20272817)
KOGAYASHI Tetsuo  Niigata University, Medical and Dental Hospital, general Dentistry and Clinical Education Unit, Associate Professor, 医歯学総合病院, 助教授 (00215344)
KURODA Takeshi  Niigata University, Institute of Medicine and Dentistry, Associate Professor, 医歯学系, 助手 (00372475)
田井 秀明  新潟大学, 医歯学総合病院, 講師 (30272826)
Project Period (FY) 2004 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥11,800,000 (Direct Cost: ¥11,800,000)
Fiscal Year 2006: ¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2005: ¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 2004: ¥4,200,000 (Direct Cost: ¥4,200,000)
Keywordsperiodontitis / gene polymorphisms / Immunoglobulin Fc receptor / Interleukin-1 / custom-made therapy / antibody therapy / cytokine therapy / Anti-TNFα antibody / 抗TNFα抗体 / リスク診断 / 特異的抗体療法 / FcγR / FcαR / IL-6R
Research Abstract

The purposes of this project were 1) establishment of genetic diagnosis for high-risk periodontitis patients, and 2) development of periodontal antibody and cytokine therapy based on genetic polymorphisms.
1) Establishment of genetic diagnosis
Fc γ R IIa-R/R131, Fc γ R IIB-232T/T and IL-1B+3954T were candidate genes of periodontitis with SLE or RA.There was strong relation between Fc α R1, IL-GR+48892A/C and aggressive periodontitis. Genes ofFc γ R IIa-H/H131, TNFR2+587, IL-6R+48892A/C, IL-6-373A9T11 correlated with the severity of chronic periodontitis. High risk-periodontitis may be explained by several common polymorphisms with cumulative profiles.
2) Development of periodontal antibody and cytokine therapy
TC-mouse-derived human monoclonal antibody to Porphyromonas gingivalis 40kDa OMP promoted neutrophil phagocytosis of P.gingivalis. This antibody to P. gingivalis 40kDa OMP protected periodontal bone loss infected by P.gingivalis in rats. Improvement of periodontal tissue was observed by administration of TNF-α antibody in a RA patient with periodontitis. These findings suggest that specific antibody and cytokine therapy may be possible in high-risk periodontitis patients.

Report

(4 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (24 results)

All 2007 2006 2005 2004

All Journal Article (22 results) Book (2 results)

  • [Journal Article] The role of genetic polymorphisms in periodontitis2007

    • Author(s)
      H.Yoshie
    • Journal Title

      Periodontology 2000 43

      Pages: 102-132

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] The r40-kDa OMP human monoclonal antibody protects against P. gingivalis-induced bone loss in rat.2007

    • Author(s)
      N.Hamada
    • Journal Title

      Journal of Periodontology (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] The r40-kDa OMP human monoclonal antibody protects against P gingivalis-induced bone loss in rat.2007

    • Author(s)
      N.Hamada
    • Journal Title

      Journal of Periodontology (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Salivary enzyme levels after scaling and Interluekin-1 genotypes in Japanese patients with chronic periodontitis2007

    • Author(s)
      H.Yoshie
    • Journal Title

      Journal of Periodontology 78/3

      Pages: 498-503

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Interleukin-6 receptor gene polymorphisms and periodontitis in a non-smoking Japanese population.2006

    • Author(s)
      J.C.Galicia
    • Journal Title

      Jouranl Clinical Periodontology 33/10

      Pages: 704-709

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Interleukin-6 receptor gene polymorphisms and periodontitis in a non-smoking Japanese populatio2006

    • Author(s)
      J.C.Galicia
    • Journal Title

      Jouranl Clinical Periodontology 33/10

      Pages: 704-709

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Antibody responses to Porphyromonas gingivalis hemagglutinin A and outer membrane protein in chronic periodontitis2006

    • Author(s)
      T.Kobayashi
    • Journal Title

      Journal of Periodontology 77/3

      Pages: 364-369

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Interleukin-6 receptor gene polymorphisms and periodontitis in a non-smoking Japanese population.2006

    • Author(s)
      J.C.Galicia
    • Journal Title

      Journal Clinical Periodontology 33/10

      Pages: 704-709

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Antibody responses to Porphyromonas gingivalis hemagglutinin A and outer membrane protein in chronic periodontitis2006

    • Author(s)
      Tetsuo Kobayashi
    • Journal Title

      Journal of Periodontology 77・3(In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The role of genetic polymorphisms in periodontitis2006

    • Author(s)
      Hiromasa Yoshie
    • Journal Title

      Periodontology 2000 (印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Interleukin-6 (IL-6) -373A9T11 allele is associated with reduced susceptibility to chronic periodontitis in Japanese subjects and decreased serum IL-6 level.2005

    • Author(s)
      K.Komatsu
    • Journal Title

      Tissue Antigens 65/1

      Pages: 110-114

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The trans-chromosomic mouse-derived human monoclonal antibody promotes phagocytosis of Porphyromonas gingivalis by neutrophils.2005

    • Author(s)
      A.Takauchi
    • Journal Title

      Journal of Periodontology 76/5

      Pages: 680-685

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Interleukin-6(IL-6)-373A9T11 allele is associated with reduced susceptibility to chronic periodontitis in Japanese subjects and decreased serum IL-6 level2005

    • Author(s)
      K.Komatsu
    • Journal Title

      Tissue Antigens 65/1

      Pages: 110-114

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The trans-chromosomic mouse-derived human monoclonal antibody promotes phagocytosis of Porphyromonas gingivalis by neutrophils2005

    • Author(s)
      A.Takauchi
    • Journal Title

      Journal of Periodontology 76/5

      Pages: 680-685

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Genetic polymorphisms and periodontitis2005

    • Author(s)
      H.Yoshie
    • Journal Title

      Interface Oral Health Science

      Pages: 131-139

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The trans-chromosomic mouse-derived human monoclonal antibody promotes phagocytosis of Porphyrowonas gingivalis by neutrophils2005

    • Author(s)
      Ayano Takauchi
    • Journal Title

      Journal of Periodontology 76・5

      Pages: 18-23

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Association of Fcγ receptor IIa genotype with chronic periodontitis in Caucasians.2004

    • Author(s)
      K.Yamamoto
    • Journal Title

      Journal of Periodontology 75/4

      Pages: 517-522

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Association of Fcy receptor lla genotype with chronic periodontitis in Caucasians2004

    • Author(s)
      K.Yamamoto
    • Journal Title

      Journal of Periodontology 75/4

      Pages: 517-522

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Targeting of Porphyromonas gingivalis with a bispecific antibody directed to FcαRI(CD89) improves in vitro clearance by gingival crevicular neutrophils.2004

    • Author(s)
      T.Kobayashi
    • Journal Title

      Vaccine 23(5)

      Pages: 585-594

    • Related Report
      2004 Annual Research Report
  • [Journal Article] A novel polymorphism of FcαRI(CD89) associated with aggressive periodontitis.2004

    • Author(s)
      S.Kaneko
    • Journal Title

      Tissue Antigens 63(6)

      Pages: 572-577

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Association of Fcgamma receptor IIa genotype with chronic periodontitis in Caucasians.2004

    • Author(s)
      K.Yamamoto
    • Journal Title

      Journal of Periodontology 75(4)

      Pages: 515-520

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Polymorphisms in the IL-6 receptor(IL-6R) gene : strong evidence that serum levels of of soluble IL-6R are genetically influenced.2004

    • Author(s)
      JC.Galicia
    • Journal Title

      Genes and Immunity 5(6)

      Pages: 513-516

    • Related Report
      2004 Annual Research Report
  • [Book] Interface Oral Health Science ; Genetic polymorphisms and periodontitis2005

    • Author(s)
      H.Yoshie
    • Total Pages
      10
    • Publisher
      International Congress Series
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] Interface Oral Health Science2005

    • Author(s)
      Hiromasa Yoshie
    • Total Pages
      9
    • Publisher
      Genetic polymorphisms and periodontitis
    • Related Report
      2005 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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