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Investigation on Traditional Medicine system and Natural Drug Resources in Vietnam, Myanmar and Indoneisa

Research Project

Project/Area Number 16406002
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Chemical pharmacy
Research InstitutionUniversity of Toyama (2005-2006)
Toyama Medical and Pharmaceutical University (2004)

Principal Investigator

KADOTA Shigetoshi  University of Toyama, Institute of Natural Medicine, Professor, 和漢医薬学総合研究所, 教授 (90115163)

Co-Investigator(Kenkyū-buntansha) SAIKI Ikuo  University of Toyama, Institute of Natural Medicine, Professor, 和漢医薬学総合研究所, 教授 (80133776)
TEZUKA Yasuhiro  University of Toyama, Institute of Natural Medicine, Assoc.Professor, 和漢医薬学総合研究所, 助教授 (70236975)
TSUDA Masaaki  University of Toyama, Graduate School of Medicine and Pharmaceutical Sciences for Research, Professor, 大学院医学薬学研究部, 教授 (80132736)
AWALE Suresh  University of Toyama, Institute of Natural Medicine, Asst.Professor, 和漢医薬学総合研究所, 助手 (00377243)
Project Period (FY) 2004 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥13,000,000 (Direct Cost: ¥13,000,000)
Fiscal Year 2006: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2005: ¥4,600,000 (Direct Cost: ¥4,600,000)
Fiscal Year 2004: ¥5,700,000 (Direct Cost: ¥5,700,000)
KeywordsTraditional medicine / Ethnic minority / anti-malaria / Agar wood / Pancreatic cancer / BDNF / Gout / Field investigation / 薬草栽培 / オシン族 / インドネシア / 三七人参 / ベトナム / ミャンマー / チャンパ民族 / Aquilaria属植物 / 抗炎症 / 抗癌
Research Abstract

Vietnam : Conducted field investigation and interviewed traditional doctors and collected of crude drugs from a) Phu Quac island b) Cham ethnic minority area (Champa) in Ninh Thuan Raokai, Sapa, Deienbin and Namudein.
Myanmar : Visited the traditional medicinal hospitals and dispensaries in a) Yangon, Thandwae, Taung-gyi, Hindata, Pathein and collected information on traditional medicines, interviewed the healers. b) Visited Mandalay, Taung-gyi and Pindaya and collected crude drugs. Studied the preparation of fermented Cows urine medicine, its use and efficacy.
Indonesia : Conducted field survey of agarwood in Sulawesi. Information were collected on the cultivation of Aquilaria trees, infection by fungus to produce agarwood, quality evaluation and conservation methods. b) Interviewed healers from Surabaya, Madura, Singaraja and Banyuwangi, and collected information about traditional Jamu medicines.
Japan : The collected crude drugs during field investigation were screened for their anti-malaria, anti-hyperurecemia, anti-cancer (with focus on Pancreatic cancer) and brain derived neurotrophic factors (BDNF) activities. From the active plants, the principle active constituents were identified.Information on the field survey and interviews were also published as news letters.

Report

(4 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (49 results)

All 2006 2005 2004

All Journal Article (49 results)

  • [Journal Article] Angelmarin, a novel anti-cancer agent able to eliminate the tolerance of cancer cells to nutrient starvation2006

    • Author(s)
      Suresh Awale
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters 16・3

      Pages: 581-583

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation2006

    • Author(s)
      Suresh Awale
    • Journal Title

      Cancer Research 66・3

      Pages: 1751-1757

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Xanthine oxidase inhibitors from the flowers of Chrysanthemum sinense2006

    • Author(s)
      Mai Thanh, Thi Nguyen
    • Journal Title

      Planta Medica 72・1

      Pages: 46-51

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] New sesquiterpene from Vietnamese agarwood and its induction effect on brain-derived neurotrophic factor mRNA expression in vitro2006

    • Author(s)
      Jun-ya Ueda
    • Journal Title

      Bioorganic & Medicinal Chemistry 14・10

      Pages: 3571-3574

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Antimalarial activity of cassane- and norcassane-type diterpenes from Caesalpinia crista and their structure-activity relationship2006

    • Author(s)
      Surya Kant Kalauni
    • Journal Title

      Biological & Pharmaceutical Bulletin 29・5

      Pages: 1050-1052

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The healing art of traditional medicines in Myanmar2006

    • Author(s)
      Suresh Awale
    • Journal Title

      Journal of Traditional Medicines 23・2

      Pages: 47-68

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Investigation on traditional medicine at Phu Quoc Island and Ninh Thuan Province in Vietnam2006

    • Author(s)
      Mai Thanh, Thi Nguyen
    • Journal Title

      Journal of Traditional Medicines 23・2

      Pages: 69-82

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Angelmarin, a Novel Anticancer Agent Able to Eliminate the Tolerance of Cancer Cells to Nutrition Starvation2006

    • Author(s)
      Awale S., Nakashima E.M.N., Kalauni S.K., Tezuka Y., Lu J., Kurashima Y., Esumi H., Kadota S.
    • Journal Title

      Bioorg.Med.Chem.Lett. 16

      Pages: 581-583

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Identification of arctigenin as an Anti-tumor Agent having activity to Eliminate Cancer Cell's Tolerance to Nutrient Starvation2006

    • Author(s)
      Awale S., Lu J., Kalauni S.K., Kurashima Y., Tezuka Y., Kadota S., Esumi H.
    • Journal Title

      Cancer Res. 66

      Pages: 1751-1753

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Xanthine Oxidase Inhibitors from the Flowers of Chrysanthemum sinense2006

    • Author(s)
      Nguyen M.T., Awale S., Tezuka Y., Ueda J., Tran Q.L., Kadota S.
    • Journal Title

      Planta med. 72

      Pages: 46-51

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] New sesquiterpene from Vietnamese agarwood and its induction effect on brain-derived neurotrophic factor mRNA expression in vitro2006

    • Author(s)
      Ueda J., Imamura L., Tezuka Y., Tran A.L., Tsuda M., Kadota S.
    • Journal Title

      Bioorg.Med.Chem. 14

      Pages: 3571-3574

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Antimalarial Activity of Cassane- and Norcassane-type Diterpenes from Caesalpinia Crista and Their Structure-Activity Relationship2006

    • Author(s)
      Kalauni S.K., Awale S., Tezuka Y., Banskota A.H., Linn T.Z., Asih P.B.S., Syafruddin D., Kadota S.
    • Journal Title

      Biol.Pharm.Bull. 29

      Pages: 1050-1052

    • NAID

      110005602240

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The Healing Art of Traditional Medicines in Myanmar2006

    • Author(s)
      Awale S., Linn T.Z., Than M.M., Saiki I., Kadota S.
    • Journal Title

      J.Trad.Med. 23

      Pages: 47-68

    • NAID

      110004737722

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Investigation on traditional medicine at Phu uoc Island and Ninh Thuan Province in Vietnam2006

    • Author(s)
      Nguyen M.T., Tran Q.L., Nakashima E.M.N., Awale S., Kadota S.
    • Journal Title

      J.Trad.Med. 23

      Pages: 69-82

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Xanthine oxidase inhibitors from flowers of Chrysanthemum sinense2006

    • Author(s)
      Mai Thanh Thi Nguyen
    • Journal Title

      Planta Medica 72・1

      Pages: 46-51

    • Related Report
      2006 Annual Research Report
  • [Journal Article] New sesquiterpene from Vietnamese agarwood and its induction effect on brain-derived neurotrophic factor mRNA expression in vitro2006

    • Author(s)
      Jun-ya Ueda
    • Journal Title

      BIoorganic & Medicinal Chemistry 14・10

      Pages: 3571-3574

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Antimalarial activity of cassane-and norcassane-type diterpenes from Caesalpinia crista and their structure-activity relationship2006

    • Author(s)
      Surya K.Kalauni
    • Journal Title

      Biological & Pharmaceutical Bulletin 29・5

      Pages: 1050-1052

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cassane- and Norcassane-Type Diterpenes from Caesalpinia crista of Indonesia and Their Antimalarial Activity against the Growth of Plasmodium falciparum2005

    • Author(s)
      Thein Zaw Linn
    • Journal Title

      Journal of Natural Products 68・5

      Pages: 706-710

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Neoflavonoids and Related Constituents from Nepalese Propolis and Their Nitric Oxide Production Inhibitory Activity2005

    • Author(s)
      Suresh Awale
    • Journal Title

      Journal of Natural Products 68・6

      Pages: 858-864

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Xanthine Oxidase Inhibitors from the Heartwood of Vietnamese Caesalpinia sappan2005

    • Author(s)
      Mai Thanh, Thi Nguyen
    • Journal Title

      Chemical & Pharmaceutical Bulletin 53・8

      Pages: 984-988

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Methyl Migrated Cassane-Type Furanoditerpenes of Caesalpinia crista from Myanmar2005

    • Author(s)
      Surya Kant Kalauni
    • Journal Title

      Chemical & Pharmaceutical Bulletin 53・10

      Pages: 1300-1304

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Field survey of agarwood cultivation at Phu Quoc Island in Vietnam2005

    • Author(s)
      Eduardo Massao, N. Nakashima
    • Journal Title

      Journal of Traditional Medicines 22・5

      Pages: 296-300

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] Hypouricemic Effects of Acacetin and 4, 5-O-Dicaffeoylquinic Acid Methyl Ester on Serum Uric Acid Levels in Potassium Oxonate-Pretreated Rats2005

    • Author(s)
      Mai Thanh, Thi Nguyen
    • Journal Title

      Biological & Pharmaceutical Bulletin 28・ 12

      Pages: 2231-2234

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] New Cassane- and Norcassane-type Diterpenes from Caesalpinia crista of Indonesia and Their Antimalarial Activity against the Growth of Plasmodium falciparum2005

    • Author(s)
      Linn T.Z., Awale S., Tezuka Y., Banskota A.H., Kalauni S.K., Attamimi F., Ueda J., Asih P.B.S., Syafruddin D., Tanaka K., Kadota S.
    • Journal Title

      J.Nat.Prod. 68

      Pages: 706-710

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Flavanoids from Nepalese Propolis and Their Nitric Oxide Production Inhibitory Activity2005

    • Author(s)
      Awale S., Shrestha S.P., Tezuka Y., Ueda J., Matsushige K., Kadota S.
    • Journal Title

      J.Nat.Prod. 68

      Pages: 858-864

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Xanthine Oxidase Inhibitors from the Heartwood of Vietnamese Caesalpinia sappan2005

    • Author(s)
      Nguyen M.T., Awale S., Tezuka Y., Tran Q.L., Kadota S.
    • Journal Title

      Chem.Pharm.Bull. 53

      Pages: 984-988

    • NAID

      10016655946

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] New Cassane-type Diterpenes of Caesalpinia crista from Myanmar2005

    • Author(s)
      Kalauni S.K., Awale S., Tezuka Y., Banskota A.H., Linn T.Z., Kadota S.
    • Journal Title

      Chem.Pharm.Bull. 53

      Pages: 214-218

    • NAID

      10016652259

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Methyl Migrated Cassane-Type Furanoditerpenes of Caesalpinia crista from Myanmar2005

    • Author(s)
      Kalauni S.K., Awale S., Tezuka Y., Banskota A.H., Linn T.Z., Kadota S.
    • Journal Title

      Chem.Pharm.Bull. 53

      Pages: 1300-1304

    • NAID

      110003666262

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Field survey of agarwood cultivation at Phu Quoc Island in Vietnam2005

    • Author(s)
      Nakashima E.M.N., Nguyen M.T.T., Tran Q.L., Kadota S.
    • Journal Title

      J.Trad.Med. 22

      Pages: 296-300

    • NAID

      130004495463

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Hypouricemic Effects of Acacetin and 4,5-O-Dicaffeoylquinic Acid Methyl Ester on Serum Uric Acid Levels in Potassium Oxonate-Pretreated Rats2005

    • Author(s)
      Nguyen M.T., Awale S., Tezuka Y., Shi L., Zaidi S.F.H., Ueda J., Tran Q.L., Murakami Y., Matsumoto K., Kadota S.
    • Journal Title

      Biol.Pharm.Bull. 28

      Pages: 2231-2234

    • NAID

      110004049121

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Xanthine oxidase inhibitors from the heartwood of Vietnamese Caesalpinia sappan2005

    • Author(s)
      Mai Thanh Thi Nguyen
    • Journal Title

      Chemical and Pharmaceutical Bulletin 53・8

      Pages: 984-988

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Cassane- and norcassane-type diterpenes from Caesalpinia crista of Indonesia and their antimalarial activity against the growth of Plasmodium falciparum2005

    • Author(s)
      Thein Zaw Linn
    • Journal Title

      Journal of Natural Products 68・5

      Pages: 706-710

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Methyl migrated cassane-type furanoditerpenes of Caesalpinia crista from Myanmar2005

    • Author(s)
      Surya Kant Kalauni
    • Journal Title

      Chemical and Pharmaceutical Bulletin 53・10

      Pages: 1300-1304

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Hypouricamic effects of acacetin and 4,5-O-dicaffeoylquinic acid methyl ester on serum uric acid levels in potassium oxonate-pretreated rats2005

    • Author(s)
      Mai Thanh Thi Nguyen
    • Journal Title

      Biological and Pharmaceutical Bulletin 28・12

      Pages: 2231-2234

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A field survey of agarwood in Indonesia2005

    • Author(s)
      Subehan
    • Journal Title

      Journal of Traditional Medicines 22・4

      Pages: 244-251

    • Related Report
      2005 Annual Research Report
  • [Journal Article] New cassane-type Diterpenes of Caesalpinia crista from Myanmar2005

    • Author(s)
      Surya K.Kalauni
    • Journal Title

      Chemical Pharmaceutical Bulletin (印刷中)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Neoorthosiphonone A; a nitric oxide (NO) inhibitory diterpene with new carbon skeleton from Orthosiphon stamineus2004

    • Author(s)
      Suresh Awale
    • Journal Title

      Tetrahedron Letters 45・7

      Pages: 1359-1362

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Staminane- and Isopimarane-Type Diterpenes from Orthosiphon stamineus of Taiwan and Their Nitric Oxide Inhibitory Activity2004

    • Author(s)
      Mai Thanh, Thi Nguyen
    • Journal Title

      Journal of Natural Products 67・4

      Pages: 654-658

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Xanthine Oxidase Inhibitory Activity of Vietnamese Medicinal Plants2004

    • Author(s)
      Mai Thanh, Thi Nguyen
    • Journal Title

      Biological & Pharmaceutical Bulletin 27・9

      Pages: 1414-1421

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Neosappanone A, a xanthine oxidase (XO) inhibitory dimeric methanodibenzoxocinone with a new carbon skeleton from Caesalpinia sappan2004

    • Author(s)
      Mai Thanh, Thi Nguyen
    • Journal Title

      Tetrahedron Letters 45・46

      Pages: 8519-8522

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Cassane- and Norcassane-Type Diterpenes of Caesalpinia crista from Myanmar2004

    • Author(s)
      Surya Kant Kalauni
    • Journal Title

      Journal of Natural Products 67・11

      Pages: 1859-1863

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Neoorthosiphonone A, a Nitric oxide (NO) Inhibitory Diterpene with a New Carbon Skeleton from Orthosiphon stamineus2004

    • Author(s)
      Awale S., Tezuka Y., Kobayashi M., Ueda J., Kadota S.
    • Journal Title

      Tetrahedron Lett. 45

      Pages: 1359-1362

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Staminane-and Isopimarane-type Diterpenes from Orthosiphon stamineus of Taiwan and Their Nitric Oxide Inhibitory Activity2004

    • Author(s)
      Nguyen M.T., Awale S., Tezuka Y., Chien-Hsiung C., Kadota S.
    • Journal Title

      J.Nat.Prod. 67

      Pages: 654-658

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Xanthine Oxidase Inhibitory Activity of Vietnamese Medicinal Plants2004

    • Author(s)
      Nguyen M.T., Awale S., Tezuka Y., Tran Q.L., Watanabe H., Kadota S.
    • Journal Title

      Biol.Pharm.Bull. 27

      Pages: 1414-1421

    • NAID

      110003608986

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Neosappanone A, a Xanthine Oxidase (XO) Inhibitory Dimeric Methanodibenzoxocinone with a New Carbon Skeleton from Caesalpinia sappan2004

    • Author(s)
      Nguyen M.T., Awale S., Tezuka Y., Tran Q.L., Kadota S.
    • Journal Title

      Tetrahedron Lett. 45

      Pages: 8519-8522

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Cassane- and Norcassane-type Diterpenes from Caesalpinia crista from Myanmar2004

    • Author(s)
      Kalauni S.K., Awale S., Tezuka Y., Banskota A.H., Linn T.Z., Kadota S.
    • Journal Title

      J.Nat.Prod. 67

      Pages: 1859-1863

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Neoorthosiphonone A ; A nitric oxide (NO) inhibitory diterpene with new carbon skeleton from Orthosiphon stamineus2004

    • Author(s)
      Suresh Awale
    • Journal Title

      Tetrahedron Letters 45・7

      Pages: 1359-1362

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Neosappanone A, a xanthine oxidase (XO) inhibitory dimeric methano-dibenzoxocinone with a new carbon skeleton from Caesalpinia sappan2004

    • Author(s)
      Mai Thanh Thi Nguyen
    • Journal Title

      Tetrahedron Letters 45・46

      Pages: 8519-8522

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Cassane- and Norcassane-Type Diterpenes of Caesalpinia crista from Myanmar2004

    • Author(s)
      Surya K.Kalauni
    • Journal Title

      Journal of Natural Products 67・11

      Pages: 1859-1863

    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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