| Project/Area Number |
16406003
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Drug development chemistry
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| Research Institution | Osaka university |
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Principal Investigator |
MURAKAMI Nobutoshi Osaka University, Graduate school of pharmaceutical sciences, Professor, 薬学研究科, 寄附講座教授 (00210013)
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| Co-Investigator(Kenkyū-buntansha) |
TSUJI Koji Osaka University, Graduate school of pharmaceutical sciences, Assistant Professor, 薬学研究科, 寄附講座助助手 (50359840)
TAMURA Satoru Osaka University, Graduate school of pharmaceutical sciences, Assistant Professor, 薬学研究科, 寄附講座助手 (30362619)
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| Project Period (FY) |
2004 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥12,900,000 (Direct Cost: ¥12,900,000)
Fiscal Year 2006: ¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 2005: ¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 2004: ¥4,300,000 (Direct Cost: ¥4,300,000)
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| Keywords | malaria / trypanosome / leishmania / parasitic infectious disease / Central Africa / traditional antiinfectious medicinal plants / biflavonoid / artemisinin / 中央アフリカ薬用植物 / コンゴ民主共和国 / プロアンソシアニジンン |
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| Research Abstract |
Extensive exploration research for traditional anti-infectious medicinal plants in Central Africa disclosed twenty candidate medicinal plants. As a result of evaluation for in vitro antimalarial and trypanocidal activity of these collected medicinal plants, the MeOH extracts from Garcinia kola and Artemisia annua were shown to exhibit significantly potent antimalarial and trypanocidal activity, respectively.
Bioassay guided separation of the extracts resulted in isolation of three biflavonoids and artemisinin as responsible bioactive principles.
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