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Genetic effects and biological concentration of radionuclides in plants and animals after Chernobyl catastrophe.

Research Project

Project/Area Number 16406019
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Hygiene
Research InstitutionOsaka University

Principal Investigator

NAKAJIMA Hiroo  Osaka University, Graduate School of Medicine, Assistant, 医学系研究科, 助手 (20237275)

Co-Investigator(Kenkyū-buntansha) SAITO Tadashi  Osaka University, Radioisotope Research Center, Professor, ラジオアイソトープ総合センター, 教授 (50153812)
HONGYO Tadashi  Osaka University, Graduate School of Medicine, Associate Professor, 医学系研究科, 助教授 (90271569)
梁 治子  大阪大学, 医学系研究科, 助手 (90301267)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥10,600,000 (Direct Cost: ¥10,600,000)
Fiscal Year 2005: ¥5,100,000 (Direct Cost: ¥5,100,000)
Fiscal Year 2004: ¥5,500,000 (Direct Cost: ¥5,500,000)
KeywordsChernobyl catastrophe / Biodosimeter / Biological concentration / Low dose radiation / Gene damages / Food chain / Low dose rate radiation / Radioactive contamination / 内部被爆 / 低線量率放射線被爆 / 内部被曝 / 低線量率放射線被
Research Abstract

South of Belarus is highly radiocontaminated even in 19 years after the Chernobyl catastrophe in 1986, and consequent environmental changes are stored in the soil, plants and animals. The major radionuclides in the contaminated areas are ^<137>Cs and ^<90>Sr, and their physical half lives are 30.2 and 28.9 years, respectively. Slow self-cleaning efficiency of the soil (estimated half life is 24 years) resulted in the long term radiocontamination in the closed environment. It is expected that the radionuclides are concentrated by the food chain into the organisms which are living in the contaminated area, and radionuclides remain in the irradiated organisms not only externally but also internally for long periods. The evidence of radiation effects for the organisms living in the contaminated area were reported by many scientists. Chromosome aberration rate in mice and frogs were increased twice higher than before catastrophe. But most of reports were not shown the exact radioactivity and period of exposure. The exact radioactivity in organisms should have been known to assess the long term low dose rate and low dose internal and external radiation effect.
We measured the ^<137>Cs radioactivity and its distribution in the plants (trees, berries) and animals (insects, frogs, moles, mice) in the highly contaminated area (Masani village, Gomel region, Belarus) and the low contaminated area (Babchin village, Gomel region, Belarus). The ^<137>Cs activity of mouse in 2005 was compared with mouse of 1997. The remaining rate of ^<137>Cs in organs at 2005 was about 2%. And it was estimated that the ecological half life was 1.511 years. Additionally, we tried the quantitative detection of contaminated radionuclides-induced DNA double-strand breaks by gamma-H2AX foci in mouse organs living in contaminated area. But the signal of gamma-H2AX foci was not detected even in animal cells in highly contaminated area.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (8 results)

All 2006 2005 2004

All Journal Article (7 results) Book (1 results)

  • [Journal Article] Germ-Line Mutations at a Mouse ESTR (Pc-3) Locus and Human Microsatellite Loci.2006

    • Author(s)
      Ryo, H.
    • Journal Title

      J.Radiat.Res. 47(in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Microsatellite mutations show no increases in the children of the Chernobyl liquidators.2005

    • Author(s)
      Furitsu, K.
    • Journal Title

      Mutation Research 581

      Pages: 69-82

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] P53,K-ras,c-kit and β-catenin gene mutations in sinonasal NK/T-cell lymphoma in Korea and Japan.2005

    • Author(s)
      Hongyo, T
    • Journal Title

      Oncol.Report 13

      Pages: 265-271

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] P-53, K-ras, c-kit and b-catenin gene mutations on sinonasal NK/T-cell lymphoma in Korea and Japan.2005

    • Author(s)
      Hongyo, T.
    • Journal Title

      Oncol.Report 13

      Pages: 265-271

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] P53,K-ras, c-kit and β-catenin gene mutations in sinonasal NK/T-cell lymphoma in Korea and Japan.2005

    • Author(s)
      Hongyo, T.
    • Journal Title

      Oncol.Report 13

      Pages: 265-271

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Microsatellite mutations show no increases in the children of the Chernobyl liquidators.2005

    • Author(s)
      Furitsu, K., et al.
    • Journal Title

      Mutation Research 581

      Pages: 69-82

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Transgenerational transmission of radiation- and chemically-induced tumors and congenital anomalies in mice : studies of their possible relationship to induced chromosomal and molecular changes.2004

    • Author(s)
      Nomura, T., et al.
    • Journal Title

      Cytogenet.Genome Res. 104

      Pages: 252-260

    • Related Report
      2004 Annual Research Report
  • [Book] Radiobiology and Bio-Medical Research ; A Novel SCID Biotechnology for Biomedical Studies in Human2004

    • Author(s)
      Nomura, T., et al.
    • Total Pages
      208
    • Publisher
      Narosa Pub.House, New Delhi
    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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