• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Effects of Microbial Co-infections on HIV-infected Individuals and Intervention with Lactoferrin

Research Project

Project/Area Number 16406022
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Public health/Health science
Research InstitutionNagasaki University

Principal Investigator

MORIUCHI Hiroyuki  Nagasaki University, Graduate School of Biomedical Sciences, Professor (90315234)

Co-Investigator(Kenkyū-buntansha) OISHI Kazunori  Osaka University, Institute for Microbial Diseases, professor (80160414)
Project Period (FY) 2004 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥7,650,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2006: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 2005: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 2004: ¥2,800,000 (Direct Cost: ¥2,800,000)
Keywordsvirus / infectious diseases / biological molecules / microbes / immunology / ラクトフェリン / HIV-1 / GBウイルス / TTウイルス / viral load / quasispecies / フィールド研究 / タイ / HHV-7 / Viral load / quasi-species
Research Abstract

1. Effects of GB virus-C (GBV-C) infection on HIV-infected individuals
i) Field studies in Northern Thai Lampang HIV Cohort
Approximately 11% of HIV-infected individuals in the Cohort had GBV-C viremia. Genotypic analyses demonstrated that 27%, 51% and 22% were genotype-2 (G2), G3 and G4, respectively. With statistical significance, HIV (+)/GBV-C(+) patients had higher CD4-positive T cell counts, lower HIV loads, AIDS-defining illnesses in lower incidence, and better survival rate than HIV(+)/GBV-C(-) patients. Anti-HIV effect was most powerful in G2, followed by G4, while G3 had little effect.
ii)Bench studies
A series of infectious molecular GBV-C clones were constructed : they have Env gene derived from G2, G3 or G4 in the backbone of G2 genome. Peripheral blood mononuclear cells were transfected with those molecular clones or parent plasmid, and infected with HIV-1 in vitro. It was demonstrated that all those molecular clones variably suppressed HIV infection in this assay.
2. Studies on other viruses
i) TT virus (TTV)
Epidemiological surveys in healthy Japanese children and adults revealed that TTV infection rates were 6%, 34%, 90% and 84% among one-month-old infants, four-month-old infants, 42-month-old toddlers and adults, respectively. G3 is the most common genogroups throughout all age groups. G1 is the second most common at and beyond 42 months, while G4 is the second most common at or before 4 months. TTV infection rates were higher in febrile infants than healthy infants, suggesting its role in infantile febrile illnesses, including aseptic meningitis. ii)Human herpesvirus-8 (HHV-8)
Approximately 5% of HIV-infected individuals in the Cohort were also infected with HHV-8.
3. Antiviral effects of lactoferrin
Daily intake of lactoferrin (100 mg daily) significantly ameliorated rotaviral gastroenteritis in otherwise healthy Japanese children.

Report

(5 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (15 results)

All 2008 2007 2006 2004

All Journal Article (9 results) (of which Peer Reviewed: 2 results) Presentation (6 results)

  • [Journal Article] Does intake of bovine lactoferrin-containing products ameliorate rotaviral gastroenteritis2007

    • Author(s)
      Egashira M, Takayanagi T, Moriuchi M, Moriuchi H
    • Journal Title

      Acta Paediatrica 96

      Pages: 1242-1244

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Does intake of bovine lactoferrin-containing products ameliorate rotaviral gastroenteritis?2007

    • Author(s)
      Egashira, M., Takayanagi, T., Moriuchi, M
    • Journal Title

      Acta Paediatrica 96

      Pages: 1242-1244

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Does intake of bovine lactoferrin-containing products ameliorate rotaviral ga stroenteritis?2007

    • Author(s)
      Egashira M, Takayanagi T, Moriuchi M, Moriuchi H
    • Journal Title

      Acta Paediatrica 96

      Pages: 1242-1244

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] AIDS(後天性免疫不全症候群)2006

    • Author(s)
      森内浩幸
    • Journal Title

      今日の小児治療指針 第14版

      Pages: 261-261

    • Related Report
      2006 Annual Research Report
  • [Journal Article] HIV感染症2006

    • Author(s)
      森内浩幸
    • Journal Title

      小児科診療 69:増刊号

      Pages: 221-225

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Norepinephrine inhibits human immunodeficiency virus type-1 infection through the NF-kappaB inactivation.2006

    • Author(s)
      Moriuchi M
    • Journal Title

      Virology 345

      Pages: 167-173

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Seminal Fluid Enhances Replication of Human T-Cell Leukemia Virus Type I : Implications for Sexual Transmission.2004

    • Author(s)
      Moriuchi, M., Moriuchi, H.
    • Journal Title

      Journal of Virology 78

      Pages: 12709-12711

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Cell-Type-Dependent Effect of Transforming Growth Factor-β, a Major Cytokine in Breast Milk, on HIV-1 Infection of Mammary Epithelial MCF-7 Cells or Macrophages.2004

    • Author(s)
      Moriuchi, M., Moriuchi, H.
    • Journal Title

      Journal of Virology 78

      Pages: 13046-13052

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Persistent Hepatitis Associated with Chronic Active Epstein-Barr Virus Infection.2004

    • Author(s)
      Yuge A, Kinoshita E, Moriuchi M, Ohno Y, Haga H, Moriuchi H.
    • Journal Title

      Pediatric Infectious Disease Journal 23

      Pages: 74-76

    • Related Report
      2004 Annual Research Report
  • [Presentation] Favorable Clinical 0utcome in HIV-1/GB Virus-C-Coinfected Individuals in the Lampang HIV Cohort in Northern Thailand2008

    • Author(s)
      Thaisri H, Tominaga N, Naganuma M, Rojanawiwat A, Tsuchiya N, Moriuchi M, Pathipvanich P, Sawanpanyalert P, Ariyoshi K, Moriuchi H
    • Organizer
      Keystone Symposia(P1/X7/X8)
    • Place of Presentation
      カナダ・バンフ
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] avorable Clinical Outcome in HIV-1/GB Virus-C-Coinfected Individuals in the Lampang HIV Cohort in Northern Thailand2008

    • Author(s)
      Thaisri, H., Tominaga, N., Naganuma, M., Rojanawiwat, A., Tsuchiya, N., Moriuchi, M., PatTnipvanich, P., Sawanpanyalert, P., Ariyoshi K., Moriuchi, H
    • Organizer
      Keystone Symposia(P1/X7/X8)
    • Place of Presentation
      Banff, Canada.
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effects of bovine lactoferrin-containing products on rotaviral gastroenteritis in previously healthy children2007

    • Author(s)
      Egashira M, Moriuchi M, Moriuchi H
    • Organizer
      VIIIth International Lactoferrin Conference
    • Place of Presentation
      フランス・ニース
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effects of bovine lactoferrin-containing products on rotaviral gastroenteritis in previously healthy children2007

    • Author(s)
      Egashira, M., Moriuchi, M., Moriuchi, H
    • Organizer
      VIIIth International Lactoferrin Conference
    • Place of Presentation
      Nice, France
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effects of bovine lactoferrin-containing products on rotaviral gastroenteritis in previously healthy children2007

    • Author(s)
      Egashira M, Moriuchi M, Moriuchi H
    • Organizer
      第8回 国際ラクトフェリン会議
    • Place of Presentation
      フランス ニース
    • Related Report
      2007 Annual Research Report
  • [Presentation] タイ北部HIV感染者コホートにおけるGB virus-C(GBV-C)の分子疫学的調査2007

    • Author(s)
      森内 浩幸, 森内 昌子, 有吉 紅也
    • Organizer
      第21回日本エイズ学会学術集会
    • Place of Presentation
      広島
    • Related Report
      2007 Annual Research Report

URL: 

Published: 2004-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi