Studies on mechanisms underlying lasting effects of rTMS in monkeys
| Project/Area Number |
16500194
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | The University of Toky |
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Principal Investigator |
UGAWA Yoshikazu The University of Tokyo, Faculty of Medicine, Lecturer, 医学部附属病院, 講師 (50168671)
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| Co-Investigator(Kenkyū-buntansha) |
TERAO Yasuo The University of Tokyo, Faculty of Medicine, Research Associate, 医学部附属病院, 助手 (20343139)
HAYASHI Takuya National Cardiovascular Center, Primary investigator, 放射線医学部, 室長 (50372115)
ISHIDA Yasushi University of Miyazaki, Faculty of Medicine, Professor, 医学部, 教授 (20212897)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2005: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2004: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | TMS / Repetitive TIMS / Dopamine / Motor cortex / Cerebral blood flow / PET / LTP / LTD / repetitive transcranial magnetic stimulation(rTMS) / 機能画像 / PET / 難治性疼痛 / 治療 |
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| Research Abstract |
PET studies in monkeys
Glucose metabolic changes and endogenous dopamine changes were recorded during and after 2000 pulse, 5Hz rTMS with biphasic pulses by using positron emission tomography (PET) in five monkeys. Two main findings were shown. The first is that metabolic changes in the brain continued to be present for at least one week and probably two weeks (Hayashi et al, 2004). This indicates that we can elicit a continuous effect on the brain of patients when we give rTMS once a week or two weeks in the treatment. Another finding is that rTMS evokes dopamine release at basal ganglia (Ohnishi et al, 2004). This suggests that rTMS may be effective for thetreatment of patients with some kinds of movement disorders.
Studies on mechanisms for rTMS in humans
PET measurements during rTMS over DLPFC showed that it activates the ventral striatum (Ohnishi et al, in press). This means that rTMS over DLPFC must be useful for the treatment of psychiatric disorders. We also studied cerebral blood
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flow (CBF) changes under the magnetic coil using near infrared spectroscopic recordings (NIRS). The results indicate that TMS activation causes a different pattern of CBF changes from those seen in physiological activation or deactivation (Mochizuki et al, in press). This gives us useful information to elucidate which stimulation method is most effective for producing a powerful, lasting effect.
rTMS treatment for pain
rTMS over the motor cortex reduced the degree of acute pain induced by artificial injection, and PET studies during stimulation suggested that TMS reduced the pain by changing the activity of the cingulated cortex (Tamura et a., 2004a). In contrast, the same stimulation may aggravate the chronic pain induced by a special laser stimulator (Tamura et al, 2004b). These results suggest that we should carefully consider which stimulation method is effective for which pain.
Monophasic pulses are more powerful for producing a lasting effect than biphasic pulses
MEP enhancement during rTMS was much more drastic when using monophasic pulses than when using biphasic pulses (Arai et al, 2005). The lasting effect after rTMS was also more powerful in monophasic stimulation than biphasic stimulation. We are now considering a new stimulation method which must be more effective than an usual monophasic rTMS.
Based on the above results, we try to elucidate a new stimulation method best for the treatment Less
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Report
(3 results)
Research Products
(32 results)
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[Journal Article] Endogenous dopamine release induced by repetitive transcranial magnetic stimulation over the primary motor cortex : An [11C] raclopride PET study in anesthetized macaque monkeys.2004
Author(s)
Ohnishi T, Hayashi T, Okabe S, Nonaka I, Matsuda H, Iida H, Imabayashi E, Watabe H, Miyake Y, Ogawa M, Teramoto N, Ohta Y, Ejima N, Sawada T, Ugawa Y
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Journal Title
Biol Psychiat 55
Pages: 484-489
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Motor Cortical Repetitive Transcranial Magnetic Stimulation Induces Long-Term Lasting Effects in Brain Regions with Functional Connections -A monkey PET study2004
Author(s)
Hayashi T, Ohnishi T, Okabe S, Teramoto N, Nonaka Y, Watabe H, Imabayashi E, Oht Y, Jino H, Ejima N, Sawada T, Iida H, Matsuda H, Ugawa Y
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Journal Title
Ann Neurol 56
Pages: 77-85
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Endogenous dopamine release induced by repetitive transcranial magnetic stimulation over the primary motor cortex : An[11C]raclopride PET study in anesthetized macaque monkeys.2004
Author(s)
Ohnishi T, Hayashi T, Okabe S, Nonaka I, Matsuda H, Iida H, Imabayashi E, Watabe H, Miyake Y, Ogawa M, Teramoto N, Ohta Y, Ejima N, Sawada T, Ugawa Y
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Journal Title
Biol Psychiat 55:484-489, 2004 55
Pages: 484-499
Related Report
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[Journal Article] Motor Cortical Repetitive Transcranial Magnetic Stimulation Induces Long-Term Lasting Effects in Brain Regions with Functional Connections-A monkey PET study2004
Author(s)
Hayashi T, Ohnishi T, Okabe S, Teramoto N, Nonaka Y, Watabe H Imabayashi E, Oht Y, Jino H, Ejima N, Sawada T, Iida H, Matsuda H, Ugawa Y
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Journal Title
Ann Neurol 56
Pages: 77-85
Related Report
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[Journal Article] Facilitatory effect on the motor cortex by electrical stimulation over the cerebellum in humans2004
Author(s)
Iwata NK, Hanajima R, Furubayashi T, Tarao Y, Uesugi H, Shio Y, Enomoto H, Mochizuki H, Kanazawa I, Ugawa Y
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Journal Title
EXP Brain Res 159: 418-424, 2004 159
Pages: 418-424
Related Report
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[Journal Article] Vocal amusia in a professinal tango singer due to a right superior temporal cortex infarction.
Author(s)
Terao Y, Mizuno T, Shindoh M, Sakurai Y, Ugawa Y, Kobayashi S, Nagai C, Furubayashi T, Arai N, Okabe S, Mochizuki H, Hanajima R, Shoji Tsuji
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Journal Title
Neuropsychologia (in press)
Description
「研究成果報告書概要(欧文)」より
Related Report
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