Mechanisms of sound sequence discrimination learning motivated by reward in the rat
| Project/Area Number |
16500197
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Niigata University |
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Principal Investigator |
KUDOH Masaharu Niigata Univ., Brain Research Institute, Associate Professor, 脳研究所, 助教授 (80153310)
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| Co-Investigator(Kenkyū-buntansha) |
HISHIDA Ryuichi Niigata Univ., Brain Research Institute, Assistant, 脳研究所, 助手 (90313551)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2005: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2004: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | Sound sequence / Discrimination / Learning / Reward / Dopamine receptors / Auditory cortex / Nucleus accumbens / Rats |
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| Research Abstract |
We have previously reported that sound sequence discrimination learning requires cholinergic inputs to the auditory cortex (AC) in rats. In that study, reward was used for motivating discrimination behavior in rats. Therefore, dopaminergic inputs mediating reward signals may have an important role in the learning. We tested the possibility in the present study. Rats were trained to discriminate sequences of two sound components, and licking behavior in response to one of the two sequences was rewarded with water. To identify the dopaminergic inputs responsible for the learning, dopaminergic afferents to the AC were lesioned with local injection of 6-hydroxydopamine (6-OHDA). The injection attenuated sound sequence discrimination learning, while it had no effect on discrimination between the sound components of the sequence stimuli. Local injection of 6-OHDA into the nucleus accumbens attenuated sound discrimination learning. However, not only discrimination learning of sound sequence but also that of the sound components were impaired. SCH23390 (0.2mg/kg, i.p.), a D1 receptor antagonist, had no effect on sound sequence discrimination learning, while it attenuated the licking behavior to unfamiliar stimuli. Haloperidol (0.5 mg/kg, i.p.), a D2 family antagonist, attenuated sound sequence discrimination learning, while it had no clear suppressive effect on discrimination of two different sound components and licking. These results suggest that D2 family receptors activated by dopaminergic inputs to the AC are required for sound sequence discrimination learning.
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Report
(3 results)
Research Products
(53 results)
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[Journal Article] Transcranial imaging of audiogenic epileptic foci in the cortex of DBA/2J mice.2006
Author(s)
Takao, T., Murakami, H., Fukuda, M., Kawaguchi, T., Kakita, A., Takahashi, H., Kudoh, M., Tanaka, R., Shibuki, K.
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Journal Title
Neuroreport 17
Pages: 267-271
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Transcranial fluorescence imaging of auditory cortical plasticity regulated by acoustic environments in mice.2006
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Takahashi, K., Hishida, R., Kubota, Y., Kudoh, M.,.Takahashi, S., Shibuki, K.
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Journal Title
Eur.J.Neurosci. 23
Pages: 1365-76
Description
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[Journal Article] Short-term plasticity visualized with flavoprotein autofluorescence in the somatosensory cortex of anaesthetized rats.2004
Author(s)
Murakami, H., Kamatani, D., Hishida, R., Takao, T., Kudoh, M., Kawaguchi, T., Tanaka, R., Shibuki, K.
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Journal Title
Eur.J.Neurosci. 19
Pages: 1352-1360
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