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Study of verification and origin of a novel medullary respiratory neuron group (para-facial respiratory group)

Research Project

Project/Area Number 16500208
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionShowa University

Principal Investigator

ONIMARU Hiroshi  Showa Univ., School of Med., Dept. of Physiol., Associate Professor, 医学部, 助教授 (30177258)

Project Period (FY) 2004 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2006: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2005: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2004: ¥2,200,000 (Direct Cost: ¥2,200,000)
Keywordsrespiratory center / medulla / rat / rhythm generation / facial nerve / central chemoreceptor / optical recording / in vitro / オピオイド / 中枢化学受容
Research Abstract

Aim of this study was to reveal cellular level entity (e.g. distribution, morphology, physiological and pharmacological characteristics) and the function of novel medullary respiratory neuron group (para-facial respiratory group, pFRG ; Onimaru & Homma, 2003). For this analysis, we used the brainstem-spinal cord preparation isolated form newborn rats. The present study revealed the following : 1)The pFRG consisted predominantly of pre-inspiratory (Pre-I) neurons. 2)Cell soma of the pFRG/Pre-I neuron was located close to the ventral surface, immediately below the pia membrane, at the level of the facial nucleus. 3)Activity of the pFRG/Pre-I neurons was not inhibited by μ-opiate agonist, DAMGO. 4)Activity of the pFRG/Pre-I neurons was reflected in the facial nerve activity. 5)When the medulla was transversely cut between the pFRG and the pre-Botzinger complex (PBC), each block of the medulla could produced spontaneous rhythmic activity under the appropriate experimental conditions. 6)These rhythmic activity corresponded to the pFRG/Pre-I (in the rostral block) and PBC/inspiratory (in the caudal block) neuron activity. 7)Rhythm of the pFRG/Pre-I neurons was depressed by increasing extracellular potassium ion concentration, application of a persistent sodium channel blocker (riluzole) or lowering CO2 pressure, whereas the PBC/inspiratory activity was more resistant to these manipulations. 8)When the medulla was cut through the midline, rhythmic activity of the pFRG/Pre-I neurons was maintained independently in the right and left medulla, but PBC-inspiratory activity was stopped. These findings showed that mechanism of rhythm generation by the pFRG/Pre-I neurons are essentially different from that of PBC-inspiratory neurons and suggested that the pFRG/Pre-I neurons determine basic respiratory rhythm under normal experimental condition with normal (or lower) external potassium concentration.

Report

(4 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (39 results)

All 2007 2006 2005 2004 Other

All Journal Article (38 results) Book (1 results)

  • [Journal Article] Spontaneous Oscillatory Burst Activity in the Piriform-Amygd ala Region and its Relation to In Vitro Respiratory Activity in Newborn Rats.2007

    • Author(s)
      Onimaru H, Homma I.
    • Journal Title

      Neuroscience 144

      Pages: 387-394

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Novel axonal projection from the caudal end of the ventro lateral medulla to the intermediolateral cell column.2007

    • Author(s)
      Iigaya K, Kumagai H, Onimaru H, et al.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol. 292

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Spontaneous Oscillatory Burst Activity in the Piriform-Amygdala Region and its Relation to In Vitro Respiratory Activity in Newborn Rats.2007

    • Author(s)
      Onimaru H, Homma I.
    • Journal Title

      Neuroscience 144

      Pages: 387-394

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Novel axonal projection from the caudal end of the ventrolateral medulla to the intermediolateral cell column.2007

    • Author(s)
      Iigaya K, Kumagai H, Onimaru H, Kawai A, Oshima N, Onami T, Takimoto C, Kamayachi T, Hayashi K, Saruta T, Itoh H.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol 292

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Novel axonal projection from the caudal end of the ventrolateral medulla to the intermediolateral cell column.2007

    • Author(s)
      Iigaya K, Kumagai H, Onimaru H et al.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol. 292

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Respiration-related rhythmic activity in the rostral medulla of newborn rats.2006

    • Author(s)
      Onimaru H, Kumagawa Y, Homma I.
    • Journal Title

      J Neurophysiol. 96

      Pages: 55-61

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Mechanisms of CO2/H+ chemoreception by respiratory rhythm generator neurons in the medulla from newborn rats in vitro.2006

    • Author(s)
      Kawai A, Onimaru H, Homma I.
    • Journal Title

      J. Physiol. 527

      Pages: 525-537

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] The para-facial respiratory group (pFRG)/ pre-Botzinger Complex (preBotC) is the primary site of respiratory rhythm generation in the mammal.2006

    • Author(s)
      Onimaru H, Homma I, Feldman JL, Janczewski WA.
    • Journal Title

      J Appl Physiol. 100

      Pages: 2094-2095

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Respiration-related rhythmic activity in the rostral medulla of newborn rats.2006

    • Author(s)
      Onimaru H, Kumagawa Y, Homma I.
    • Journal Title

      J Neurophysiol 96

      Pages: 55-61

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Mechanisms of CO2/H+ chemoreception by respiratory rhythm generator neurons in the medulla from newborn rats in vitro.2006

    • Author(s)
      Kawai A, Onimaru H, Homma I.
    • Journal Title

      J Physiol 572

      Pages: 525-537

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The para-facial respiratory group (pFRG)/ pre Botzinger Complex (preBotC) is the primary site of respiratory rhythm generation in the mammal.2006

    • Author(s)
      Onimaru H, Homma I, Feldman JL, Janczewski WA.
    • Journal Title

      J Appl Physiol 100

      Pages: 2094-2095

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Respiration-related rhythmic activity in the rostral medulla of newborn rats2006

    • Author(s)
      Onimaru, H., Kumagawa, Y., Homma, I
    • Journal Title

      Journal of Neurophysiology (In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Mechanisms of CO_2/H^+ chemoreception by respiratory rhythm generator neurons in the medulla from newborn rats in vitro2006

    • Author(s)
      Kawai, A, Onimaru, H., Homma, I
    • Journal Title

      Journal of Physiology (In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Optical imaging of respiratory neuron activity from the dorsal view of the lower brainstem.2005

    • Author(s)
      Onimaru H, Homma I.
    • Journal Title

      Clinical and Experimental Pharmacology and Physiology 32

      Pages: 297-301

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] Developmental changes in the spatio-temporal pattern of respiratory neuron activity in the medulla of late fetal rat.2005

    • Author(s)
      Onimaru H, Homma I.
    • Journal Title

      Neuroscience 131

      Pages: 969-977

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] Electrophysiological properties of rostral ventrolateral medulla neurons in ansiotensin II 1a receptor knockout mice.2005

    • Author(s)
      Matsuura T, Onimaru H
    • Journal Title

      Hypertension 46

      Pages: 349-354

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Localization and properties of respiratory neurons in the rostral pons of the newborn rat.2005

    • Author(s)
      Kobayashi S, Onimaru H, Inoue M, Inoue T, Sasa R
    • Journal Title

      Neuroscience 134

      Pages: 317-325

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Facilitation of respiratory rhythm by aμ-opioid agonist in newborn rat pons-medulla-spinal cord preparations.2005

    • Author(s)
      Tanabe A, Fujii T, Onimaru H
    • Journal Title

      Neurosci Lett 375

      Pages: 19-22

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Cannabinoid suppressed bicuculline-induced convulsion without respiratory depression in the brainstem-spinal cord preparation from newborn rats.2005

    • Author(s)
      Koda S, Takeda S, Onimaru H, Akada S, Sakamoto A.
    • Journal Title

      Biomed Res 26

      Pages: 241-247

    • NAID

      130004903694

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Electrophysiological properties of rostral ventrolateral medulla neurons in angiotensin II la receptor knockout mice.2005

    • Author(s)
      Matsuura T, Kumagai H, Onimaru H, Kawai A, Iigaya K, Onami T, Sakata K, Oshima N, Sugaya T, Saruta T.
    • Journal Title

      Hypertension 46

      Pages: 349-54

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Homma I Developmental changes in the spatio-temporal pattern of respiratory neuron activity in the medulla of late fetal rat.2005

    • Author(s)
      Onimaru H
    • Journal Title

      Neuroscience 131

      Pages: 969-977

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Onimaru H Facilitation of respiratory rhythm by a μ-opioid agonist in newborn rat pons-medulla-spinal cord preparations.2005

    • Author(s)
      Tanabe A, Fujii T
    • Journal Title

      Neurosci Lett 375

      Pages: 19-22

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Electrophysiological properties of rostral ventrolateral medulla neurons in angiotensin II 1a receptor knockout mice.2005

    • Author(s)
      Matsuura T, Onimaru H
    • Journal Title

      Hypertension 46

      Pages: 349-354

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Localization and properties of respiratory neurons in the rostral pons of the newborn rat.2005

    • Author(s)
      Kobayashi S, Onimaru H, Inoue M, Inoue T, Sasa R.
    • Journal Title

      Neuroscience 134

      Pages: 317-325

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Facilitation of respiratory rhythm by a μ-opioid agonist in newborn rat pons-medulla-spinal cord preparations.2005

    • Author(s)
      Tanabe A, Fujii T., Onimaru H.
    • Journal Title

      Neuroscience Letters 375

      Pages: 19-22

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Malfunction of Respiratory-Related Neuronal Activity in Na+, K+-ATPase α2 Subunit-Deficient Mice Is Attributable to Abno rmal Cl- Homeostasis in Brainstem Neurons.2004

    • Author(s)
      Ikeda K, Onimaru H, et al.
    • Journal Title

      J Neurosci 24

      Pages: 10693-10701

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] In vitro visualization of respiratory neuron activity in the newborn mouse ventral medulla.2004

    • Author(s)
      Onimaru, H., Arata, A., Arata, S., Cleary, M.L.
    • Journal Title

      Dev Brain Res 153

      Pages: 275-297

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Pbx3 deficiency results in central hypoventilation.2004

    • Author(s)
      Rhee, J.W., Onimaru, H.(7人中6番目)
    • Journal Title

      Amer. J. Pathol. 165

      Pages: 1343-1350

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates.2004

    • Author(s)
      Cheng, L., Onimaru, H.(15人中14番目)
    • Journal Title

      Nature Neurosci. 7

      Pages: 510-517

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Pbx3 deficiency results in central hypoventilation.2004

    • Author(s)
      Rhee, J.W., Arata A., Selleri L., Jacobs Y., Arata S., Onimaru, H.Cleary M.L.
    • Journal Title

      Amer. J. Pathol 165

      Pages: 1343-1350

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Kawakami K Malfunction of Respiratory-Related Neuronal Activity in Na+, K+-ATPase a2 Subunit-Deficient Mice Is Attributable to Abnormal Cl- Homeostasis in Brainstem Neurons.2004

    • Author(s)
      Ikeda K, Onimaru H, Yamada J, Inoue K, Ueno S, Onaka T, Toyoda H, Arata A, Ishikawa T, Taketo MM, Fukuda A
    • Journal Title

      J Neurosci 24

      Pages: 10693-10701

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Cleary ML In vitro visualization of respiratory neuron activity in the newborn mouse ventral medulla.2004

    • Author(s)
      Onimaru H, Arata A, Arata S
    • Journal Title

      Dev Brain Res 153

      Pages: 275-279

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Ma Q Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates.2004

    • Author(s)
      Cheng L, Arata A, Mizuguchi R, Qian Y, Karunaratne A, Gray PA, Arata S, Shirasawa S, Bouchard M, Luo P, Chen CL, Busslinger M, Goulding M, Onimaru H
    • Journal Title

      Nature Neurosci 7

      Pages: 510-517

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Malfunction of respiratory-related neuronal activity in Na^+, K^+-ATPase α2 subunit-deficient mice is attributable to abnormal Cl-homeostasis in brainstem neurons.2004

    • Author(s)
      Ikeda K, Onimaru H.他
    • Journal Title

      J.Neurosceince 24

      Pages: 10693-10701

    • Related Report
      2004 Annual Research Report
  • [Journal Article] In vitro visualization of respiratary neuron activity in the newborn mouse ventral medulla2004

    • Author(s)
      Onimaru H., Arata A., 他
    • Journal Title

      Dev.Brain Res. 153

      Pages: 275-279

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates.2004

    • Author(s)
      Cheng L., Arata, A.他
    • Journal Title

      Nature Neuroscience 7

      Pages: 510-517

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Optical imaging of respiratory neuron activity from the dorsal view of the lower brainstem.

    • Author(s)
      Onimaru H., Homma I.
    • Journal Title

      Clinical and Experimental Pharmacology and Physiology (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Developmental changes in the spatio-temporal pattern of respiratory neuron activity in the medulla of late fetal rat.

    • Author(s)
      Onimaru H., Homma I.
    • Journal Title

      Neuroscience (in press)

    • Related Report
      2004 Annual Research Report
  • [Book] 呼吸の辞典 : 11.胎児の呼吸中枢2006

    • Author(s)
      鬼丸 洋
    • Publisher
      朝倉書店
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary

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Published: 2004-04-01   Modified: 2016-04-21  

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