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Molecular mechanisms underlying progenitor migration following methylmercury exposure in the developing brain

Research Project

Project/Area Number 16500214
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionNiigata University

Principal Investigator

KAKITA Akiyoshi  Niigata University, Brain Research Institute, Associate Professor, 脳研究所, 助教授 (80281012)

Co-Investigator(Kenkyū-buntansha) SAKAMOTO Mineshi  National Institute for Minamata Disease, Department of Epidemiology, Director, 疫学研究部, 調査室長 (60344420)
TAKAHASHI Hitoshi  Niigata University, Brain Research Institute, Professor, 脳研究所, 教授 (90206839)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2005: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2004: ¥2,300,000 (Direct Cost: ¥2,300,000)
KeywordsProgenitor migration / Brain development / methylmercury / Fetal Minamata disease / Molecular pathology / DNA chip
Research Abstract

To understand the effects of methylmercury (MeHg) on neuronal and glial progenitor migration in the developing cerebral cortex, we examined profile alterations in gene expression in the telencephalic mantle following fetal or neonatal administration of MeHg, wher an apparent disrupition of the progenitor migration had been elucidated histopathologically. We applied extracted mRNA samples to two kinds of DNA microarrays, which had been made under different biotechnological concepts. Then, we performed analysis of the plenty of data according to the bioinformatics methodologies. We selected 11 molecules, which could be regarded as candidates of specific molecular cues closely associated with the migration disturbance underlying MeHg neurotoxicity.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (33 results)

All 2006 2005 2004

All Journal Article (33 results)

  • [Journal Article] Transcranial imaging of audiogenic epileptic foci in the cortex of DBA/2J mice.2006

    • Author(s)
      T.Takao
    • Journal Title

      Neuroreport 17・3

      Pages: 267-271

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Pathological heterogeneity of the precentral gyrus in Pick's disease: a study of 16 autopsy cases.2006

    • Author(s)
      K.Tsuchiya
    • Journal Title

      Acta Neuropathol. (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Transcranial imaging of audiogenic epileptic foci in the cortex of DBA/2J mice.2006

    • Author(s)
      T.Takao
    • Journal Title

      Neuroreport. 17・3

      Pages: 267-271

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Pathological heterogeneity of the precentral gyrus in Pick's disease : a study of 16 autopsy cases.2006

    • Author(s)
      K.Tsuchiya
    • Journal Title

      Acta Neuropathol (In press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Pathological heterogeneity of the precentral gyrus in pick's disease : a study of 16 autopsy cases.2006

    • Author(s)
      K.Tsuchiya
    • Journal Title

      Acta Neuropathol. (In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Pathologic features of dysplasia and accompanying alterations observed in surgical specimens from patients with intractable epilepsy.2005

    • Author(s)
      A.Kakita
    • Journal Title

      J.Child Neurol. 20・4

      Pages: 341-350

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cerebral lipoma and the underlying cortex of the temporal lobe: pathologic features associated with the malformation.2005

    • Author(s)
      A.Kakita
    • Journal Title

      Acta Neuropathol. 109・3

      Pages: 339-345

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] ErbB1 receptor ligands attenuate the expression of synaptic scaffolding proteins, GRIP1 and SAP97, in developing neocortex.2005

    • Author(s)
      D.Yokomaku
    • Journal Title

      Neuroscience 136・4

      Pages: 1037-1047

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] ヒト脳の形成障害: とくにMigratin Disordersの病理.2005

    • Author(s)
      柿田明美
    • Journal Title

      脳21 8・3

      Pages: 268-273

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Influences of dopaminergic lesion on epidermal growth factor-ErbB signals in Parkinson's disease and its model: neurotrophic implication in nigrostriatal neurons.2005

    • Author(s)
      Y.Iwakura
    • Journal Title

      J.Neurochem. 93・4

      Pages: 974-983

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] poradic four-repeat tauopathy with frontotemporal degeneration, parkinsonism and motor neuron disease.2005

    • Author(s)
      Y.-S.Piao
    • Journal Title

      Acta Neuropathol. 110・6

      Pages: 600-609

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 統合失調症の発達障害仮説とドパミン神経栄養因子2005

    • Author(s)
      那波宏之
    • Journal Title

      細胞 37・14

      Pages: 565-568

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Sporadic fatal insomnia with spongiform degeneration in the thalamus and widespread PrP^<Sc> deposition in the brain.2005

    • Author(s)
      Y.-S.Piao
    • Journal Title

      Neuropathology 25・2

      Pages: 144-149

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Frontotemporal dementia with co-occurrence of astrocytic plaques and tufted astrocytes, and severe degeneration of the cerebral white matter: a variant of corticobasal degeneration?2005

    • Author(s)
      C.-F.Tan
    • Journal Title

      Acta Neuropathol. 109・3

      Pages: 329-338

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cerebral lipoma and the underlying cortex of the temporal lobe : pathologic features associated with the malformation.2005

    • Author(s)
      A.Kakita
    • Journal Title

      Acta Neuropathol. 109・3

      Pages: 339-345

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] ErbB1 receptor ligands attenuate the expression of synaptic scaffolding proteins, GRIP1 and SAP97, in developing neocortex.2005

    • Author(s)
      D.Yokomaku
    • Journal Title

      Neuroscience. 136・4

      Pages: 1037-1047

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Pathologic features of migration disorders2005

    • Author(s)
      K.Kakita
    • Journal Title

      (in Japanese) No.21.8・3

      Pages: 268-273

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Influences of dopaminergic lesion on epidermal growth factor-ErbB signals in Parkinson's disease and its model : neurotrophic implication in nigrostriatal neurons.2005

    • Author(s)
      Y.Iwakura
    • Journal Title

      J.Neurochem. 93・4

      Pages: 974-983

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Sporadic four-repeat tauopathy with frontotemporal degeneration, parkinsonism and motor neuron disease.2005

    • Author(s)
      Y.-S.Piao
    • Journal Title

      Acta Neuropathol. 110・6

      Pages: 600-609

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Contribution of dopaminergic trophic factors to abnormal brain development of schizophremics2005

    • Author(s)
      H.Nawa
    • Journal Title

      Saibo.(in Japanese) 37・14

      Pages: 565-568

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Sporadic fatal insomnia with spongiform degeneration in the thalamus and widespread PrP^<Sc> deposition in the brain.2005

    • Author(s)
      Y.-S.Piao
    • Journal Title

      Neuropathology. 25・2

      Pages: 144-149

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Frontotemporal dementia with co-occurrence of astrocytic plaques and tufted astrocytes, and severe degeneration of the cerebral white matter : a variant of corticobasal degeneration?2005

    • Author(s)
      C.-F.Tan
    • Journal Title

      Acta Neuropathol. 109・3

      Pages: 329-338

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Pathologic features of dysplasia and accompanying alterations observed in surgical specimens from patients with intractable epilepsy.2005

    • Author(s)
      A.Karita
    • Journal Title

      J.Child Neurol. 20・4

      Pages: 341-350

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Cerebral lipoma and the underlying cortex of the temporal lobe : pathologic features associated with the malformation.2005

    • Author(s)
      A.Karita
    • Journal Title

      Acta Neuropathol 109・3

      Pages: 339-345

    • Related Report
      2005 Annual Research Report
  • [Journal Article] ヒト脳の形成障害:とくにMigratin Disordersの病理2005

    • Author(s)
      柿田明美
    • Journal Title

      脳21 8・3

      Pages: 268-273

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Sporadic fatal insomnia with spongiform degeneration in the thalamus and widespread PrP^<Se> deposition in the brain.2005

    • Author(s)
      Y.-S.Piao
    • Journal Title

      Neuropathology 25・2

      Pages: 144-149

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Frontotemporal dementia with co-occurrence of astrocytic plaques and tufted astrocytes, and severe degeneration of the cerebral white matter a variant of corticobasal degeneration?2005

    • Author(s)
      C.-F.Tan
    • Journal Title

      Acta Neuropathol. 109・3

      Pages: 329-338

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Cerebral lipoma and the underlying cortex of the temporal lobe : pathologic features associated with the malformation.2005

    • Author(s)
      A.Kakita
    • Journal Title

      Acta Neuropathol. (印刷中)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Pathologic features of dysplasia and accompanying alterations observed in surgical specimens from patients with intractable epilepsy.2005

    • Author(s)
      A.Kakita
    • Journal Title

      J.Child Neurol. (印刷中)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Changes in methylmercury accumulation in the brain of rat offspring throughout gestatin and during suckling.2004

    • Author(s)
      H.S.Pan
    • Journal Title

      Toxicol.Environ.Chem. 86

      Pages: 163-170

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Prefrontal abnormality of schizophrenia revealed by DNA microarray : impact on glial and neurotrophic gene expression.2004

    • Author(s)
      T.Sugai
    • Journal Title

      Ann.NY.Acad.Sci. 1025

      Pages: 84-91

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Dose-dependent effects of methylmercury administered during neonatal brain spurt in rats.2004

    • Author(s)
      M.Sakamoto
    • Journal Title

      Dev.Brain Res. 152・2

      Pages: 171-176

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Perinatal inflammatory cytokine challenge results in distinct neurobehavioral alterations in rats : implication in psychiatric disorders of developmental origin.2004

    • Author(s)
      M.Tohmi
    • Journal Title

      Neurosci.Res. 50・1

      Pages: 67-75

    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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