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Morphological development of human hippocampus: cross-sectional and longitudinal studies by high-resolutionmagnetic resonance imaging

Research Project

Project/Area Number 16500215
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionUniversity of Toyama (2005-2007)
Toyama Medical and Pharmaceutical University (2004)

Principal Investigator

SUZUKI Michio  University of Toyama, Graduate School of Medicine and Pharmaceutical Science, Department of Neuropsychiatry, Professor (40236013)

Co-Investigator(Kenkyū-buntansha) KAWASAKI Yasuhiro  University of Toyama, Graduate School of Medicine and Pharmaceutical Sciences, Department of Neuropsychiatry, Lecturer (80242519)
TAKAHASHI Tsutomu  University of Toyama, Graduate School of Medicine and Pharmaceutical Sciences, Department of Neuropsychiatry, Assistant Professor (60345577)
KURACHI Masayoshi  University of Toyama, Graduate School of Medicine and Pharmaceutical Sciences, Department of Neuropsychiatry, Professor (80019603)
MATSUI Mie  University of Toyama, Graduate School of Medicine and Pharmaceutical Sciences, Department of Neuropsychiatry, Associate Professor (70209485)
Project Period (FY) 2004 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,580,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2006: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2005: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2004: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywordshippocampus / amygdala / prefrontal cortex / morphological development / adolescence / schizophrenia / magnetic resonance imaging / 神経発達 / 透明中隔腔 / 視床間橋 / 統合失調症圏 / 磁気共鳴画像 / 発達 / 体積計測 / voxel-based morphometry / 髄鞘化
Research Abstract

Morphological development of human hippocampus and related brain regions and its implications in the pathophysiology of schizophrenia were investigated using magnetic resonance imaging (MRI).
1. Volumes of the hippocampus and the amygdala were significantly larger in male elder adolescents than in male younger adolescents. These results suggest a robust maturational process ongoing in the human hippocampus and amygdala during adolescence, especially in males, which maybe relevant to progress in myelination.
2. Volumetric analyses demonstrated that, in patients with schizotypal disorder, volumes of the amygdala and hippocampus were significantly reduced, whereas prefrontal volumes were preserved. Shizophrenia patients had significant volume reductions in the prefrontal areas as well as in the amygdala and hippocampus. These findings suggest that volume reductions in the amygdala and hippocampus may represent the vulnerability, whereas additional widespread involvement of the prefrontal cortex in schizophrenia may play critical roles in the manifestation of overt psychosis.
3. Structural abnormalities in the cerebral midline structures such as the cavum septi pellucidi (CSP) and the adhesio interthalamica (AI), and their relation with the volumes of the medial temporal structures were explored in schizophrenia patients. The patients with a large CSP had smaller volumes of bilateral amygdala and left posterior parahippocampal gyrus than those without it. The patients without an AI had a smaller bilateral amygdala than those with an AL These findings suggest that the abnormalities in the cerebral midline structures and the medial temporal lobe regions may reflect developmental disturbance in the neural network including the midline and associated limbic structures of the brain in schizophrenia.

Report

(5 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (20 results)

All 2008 2007 2006 2005

All Journal Article (17 results) (of which Peer Reviewed: 5 results) Presentation (3 results)

  • [Journal Article] Association between absence of the adhesio interthalamica and amygdalavolume in schizophrenia2008

    • Author(s)
      Takahashi T., Suzuki M., Nakamura K., et. al.
    • Journal Title

      Psychiatry Research Neuroimaging 162

      Pages: 101-111

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of large cavum septi pellucidi and its relation to the medial temporal lobe structures in schlzophrenia spectrum2007

    • Author(s)
      Takahashi T., Suzuki M., HaginoH., et. al.
    • Journal Title

      Prog. Neuropsychopharmacol. Biol. Psychiatry 31

      Pages: 1235-1241

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 脳形態画像による統合失調症の発症脆弱性2007

    • Author(s)
      鈴木 道雄, 高橋 努, 周 世〓 ほか
    • Journal Title

      精神神経学雑誌 109

      Pages: 339-345

    • NAID

      10019987274

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Morphologic alterations of the parcellated superior temporal gyrus in schizohprenia spectrum.2006

    • Author(s)
      Takahashi T., Suzuki M., Zhou S.-Y., et al.
    • Journal Title

      Schizophr. Research 83

      Pages: 141-143

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Temporal lobe gray matter in schizophrenia spectrum : a volumetric MRI study of the fusiform gyrus, parahippicampal gyrus, and middle and inferior temporal gyri.2006

    • Author(s)
      Takahashi T., Suzuki M., Zhou S.-Y., et al.
    • Journal Title

      Schizophr. Research 87

      Pages: 116-126

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 統合失調症の脳形態学的研究-病態形成との関わりと客観的診断法への応用-.2006

    • Author(s)
      鈴木道雄, 川崎康弘, 周 世いく, ら
    • Journal Title

      精神神経学雑誌 108

      Pages: 654-660

    • NAID

      10018363867

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 統合失調症の脆弱性と発症に関わる脳形態の変化について.2006

    • Author(s)
      鈴木道雄, 高橋 努, 周 世いく, ら
    • Journal Title

      社会精神医学会雑誌 15

      Pages: 49-54

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Male-specific volume expansion of the human hippocampus during adolescence.2005

    • Author(s)
      Suzuki M, et. al.
    • Journal Title

      Cerebral Cortex 15

      Pages: 187-193

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Morphological brain changes associated with Schneider's first rank symptoms in schizophrenia: an MRI study.2005

    • Author(s)
      Suzuki M, et. al.
    • Journal Title

      Psychological Medicine 35

      Pages: 549-560

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Differential contributions of prefrontal and temporolimbic pathology to mechanisms of psychosis.2005

    • Author(s)
      Suzuki M, et. al.
    • Journal Title

      Brain 128

      Pages: 2109-2122

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Male specific volume expansion of the human hippocampus during adolescence2005

    • Author(s)
      Suzuki, M., Hagino, H., Nohara, S., Zhou, S.Y., Kawasaki, Y., Takahashi. T., Matsui, M., Seto H., Ono, T., Kurachi, M
    • Journal Title

      Cerebral Cortex 15

      Pages: 187-193

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Morphological brain changes associated with Schneider's first rank symptoms in schizophrenia: an MRI study2005

    • Author(s)
      Suzuki, M., Zhou, S.Y., Hagino, H., Niu, L., Takahashi, T., Kawasaki, Y., Matusi, M., Seto, H., Ono, T., Kuraehi, M
    • Journal Title

      Psychological Medicine 35

      Pages: 549-560

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Differential contributions of prefrontal and temporolimbic pathology to mechanisms of psychosis2005

    • Author(s)
      Suzuki, M., Zhou, S.Y., Takahashi, T., Hagino, H., Kawasaki, Y., Niu, L., Matsui, M., Seto, H., Kurachi, M
    • Journal Title

      Brain 128

      Pages: 2109-2122

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Differential contributions of prefrontal and temporolimbic pathology to mechanisms of psychosis.2005

    • Author(s)
      Suzuki M, Zhou S-Y, Takahashi T, et al.
    • Journal Title

      Brain 128

      Pages: 2109-2122

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Morphological brain changes associated with Schneider's first rank symptoms in schizophrenia : a MRI study.2005

    • Author(s)
      Suzuki M, Zhou S-Y, Hagino H, et al.
    • Journal Title

      Psychological Medicine 35

      Pages: 549-560

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Volumetric analysis of sulci/gyri-defined in vivo frontal lobe regions in schizophrenia : precentral gyrus, cingulate gyrus and prefrontal region.2005

    • Author(s)
      Zhou S-Y, Suzuki M, Hagino H, et al.
    • Journal Title

      Psychiatry Research Neuroimaging 139

      Pages: 127-139

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Male-specific volume expansion of the human hippocampus during adolescence.2005

    • Author(s)
      Suzuki M, Hagino H, Nohara S, et al.
    • Journal Title

      Cerebral Cortex 15(2)

      Pages: 187-193

    • Related Report
      2004 Annual Research Report
  • [Presentation] Structural brain changes underlying vulnerability to schizophrenia2007

    • Author(s)
      Suzuki M.
    • Organizer
      The 2nd World Conference of Stress
    • Place of Presentation
      Budapest(Hungary)
    • Year and Date
      2007-08-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] Medial temporal volume reduction as a vulnerability marker for schizophrenia.2005

    • Author(s)
      Suzuki M, et. al.
    • Organizer
      The 8th World Congress of Biological Psychiatry
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2005-06-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Medial temporal volume reduction as a vulnerability marker for schizophrenia2005

    • Author(s)
      Suzuki, M., Hagino, H., Niu, L., Zhou, S.Y., Takahashi, T., Kawasaki, Y., Matsui, M., Kurachi, M
    • Organizer
      World Federation of Societies of Biological Psychiatry(WFSBP)- The 8th World Congress of Biological Psychiatry
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2005-06-29
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2004-04-01   Modified: 2016-04-21  

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