| Project/Area Number |
16500228
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Showa University |
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Principal Investigator |
GUAN Jian-Lian Showa Univ., Sch.of Med., Dept.of Anatomy, Assistant, 医学部, 助手 (20276538)
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| Co-Investigator(Kenkyū-buntansha) |
FUNAHASHI Hisayuki Showa Univ., Sch.of Med., Dept.of Anatomy, Associate Professor, 医学部, 助教授 (20317514)
ARATA Satoru Showa Univ., Centaer for Biotechnology, Assistant Professor, 組換えDNA実験室, 講師 (20159502)
SHIODA Seiji Showa Univ., Sch.of Med., Dept.of Anatomy, Professor, 医学部, 教授 (80102375)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2005: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2004: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | Galanin-like peptide / GPCR / feeding regulation / hypothalamus / 神経ペプチド / ニューロンネットワーク / シナプス / 免疫電顕 |
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| Research Abstract |
The hypothalamus plays a critical role in regulation of feeding behavior, energy metabolism and reproduction. A novel peptide discovered in porcine hypothalamus has 60 amino acid peptide and a non-amidated C-terminus. Since a portion of this peptide is homology with galanin, it is named galanin-like peptide (GALP). GALP is mainly produced in the hypothalamic arcuate nucleus. GALP acts in the central nervous system, where it is involved in the regulation of feeding behavior. GALP-producing neurons make neuron networks with several feeding related peptide- producing neurons. Since GALP controls food intake and energy balance, it is possible that GALP is an important factor in development of obesity. Furthermore, we have succeeded to make transgenic (Tg) mice that express green fluorescence (EGFP) in GALP-containing neurons and also to make Tg mice that express EGFP in afferent GALP neurons in brain. As a result, it appeares that GALP-containing neurons make synaptic input from the piriform cortex and amygdala. Therefore, GALP may involve in feeding behavior, energy metabolism and reproduction, further studies on the morphology and function of GALP should continue to demonstrate further the understanding in brain function.
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