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Neurotrophic role of hepatocytes growth factor (HGF) and its family member in the nervous system

Research Project

Project/Area Number 16500241
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionOsaka University

Principal Investigator

FUNAKOSHI Hiroshi  Osaka University, Graduate School Of Medicine, Associate Professor, 医学系研究科, 助教授 (40273685)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Toshikazu  Osaka University, Graduate School Of Medicine, Professor, 医学系研究科, 教授 (00049397)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2005: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2004: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsHGF / c-Met / HGF-like Protein (HLP) / Ron / neuron / microglia / neurodegeneration / neurotrophic / HLP / HFG / HGF-like Protein(HLP)
Research Abstract

HGF is originally purified and molecularly cloned as a mitogen for primary hepatocytes (Nakamura T et al., BBRC 1984 ; Nakamura T et al., Nature 1989). A large number of evidences revealed that HGF acts as a novel neurotrophic factor for a variety of neurons in vitro (Honda et al., Mol Brain Res. 1995 ; Funakoshi et al., Clin Chim Acta 2003). In addition, neurotrophic activity of HGF in a variety of neural disease model including amyotrophic lateral sclerosis is evident (Sun et al., J. Neurosci. 2002). Here we analyzed the roles for HGF in neurodegenerative disease and anxiolytic function. In addition, we analyzed the potential methods for the delivery of HGF in neural diseases, such as protein and gene therapy.
Our findings suggest that HGF plays an important role in a variety of neural diseases.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (32 results)

All 2006 2005 2004

All Journal Article (32 results)

  • [Journal Article] Prevention of apoptosis-inducing factor translocation is a possible mechanism for protective effects of hepatocyte growth factor against neuronal cell death in the hippocampus after transient forebrain ischemiai2006

    • Author(s)
      Nishimura M, Funakoshi H, 他7名
    • Journal Title

      J Cereb Blood Flow Metab. 26(3)

      Pages: 1-12

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Novel therapeutic strategy for stroke in rats by bone marrow stromal cells and ex vivo HGF gene transfer with HSV-1 vector.2006

    • Author(s)
      Zhao MZ, Funakoshi H, 他13名
    • Journal Title

      J Cereb Blood Flow Metab 18

      Pages: 1-13

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of hepatocyte growth factor on phosphorylation of extracellular signal-regulated kinase and hippocampal cell death in rats with transient forebrain ischemia.2006

    • Author(s)
      Nishimura M, Funakoshi H, 他7名
    • Journal Title

      Eur J Pharmacol. 535

      Pages: 114-124

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Anxiolytic effect of hepatocyte growth factor infused into rat brain.2006

    • Author(s)
      Isogawa K, Funakoshi H, 他5名
    • Journal Title

      Neuropsychobiology 5(1)

      Pages: 34-38

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Inhibition of apoptosis-inducing factor translocation is involved in protective effects of hepatocyte growth factor against excitotoxic cell death in cultured hippocampal neurons.2006

    • Author(s)
      Ishihara N, Funakoshi H, 他8名
    • Journal Title

      J Neurochem. 319(4)

      Pages: 1277-1286

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Intraventricular administration of hepatocyte growth factor treats mouse communicating hydrocephalus induced by transforming growth factor beta1.2006

    • Author(s)
      Tada T, Nakamura T, 他4名
    • Journal Title

      Neurobiol Dis. 21(3)

      Pages: 576-586

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of hepatocyte growth factor on signal-regulated kinase and hippocampal cell death forebrain ischemia.2006

    • Author(s)
      Niimura M, Takagi N, Takagi K, Funakoshi H, Nakamura T, Takeo S
    • Journal Title

      Eur J Pharmacol 535

      Pages: 114-124

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Novel therapeutic strategy for stroke in rats by bone and ex vivo HGF gene transfer with HSV-1 vector.2006

    • Author(s)
      Zhao MZ, Nonoguchi N, Ikeda N, Watanabe T, Furutama D, Miyazawa D, Funakoshi H, Kajimoto Y, Nakamura T, Dezawa M, Shibata MA, Otsuki Y, Coffin RS, Liu WD, Kuroiwa T, Miyatake SI
    • Journal Title

      J Cereb Blood Flow Metab 18

      Pages: 1-13

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Prevention of apoptosis-inducing factor mechanism for protective effects of hepatocyte neuronal cell death in the hippocampus after transient forebrain ischemia.2006

    • Author(s)
      Niimura M, Takagi N, Takagi K, Mizutani R, Ishihara N, Matsumoto K, Funakoshi H, Nakamura T, Takeo S
    • Journal Title

      J Cereb Blood Flow Metab 1

      Pages: 1-1

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Intraventricular administration of hepatocyte communicating hydrocephalus induced by transforming.2006

    • Author(s)
      Tada T, Zhan H, Tanaka Y, Hongo K, Matsumoto K, Nakamura T
    • Journal Title

      Neurobiol Dis 21

      Pages: 576-586

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Expression of Hepatocyte Growth Factor in Rat Skeletal Muscle.2005

    • Author(s)
      Tanaka S, Funakoshi H, 他4名
    • Journal Title

      J Phys Ther Sci. 17

      Pages: 109-113

    • NAID

      10016945664

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of fukutin deficiency in the developing mouse brain.2005

    • Author(s)
      Chiyonobu Funakoshi, 他6名
    • Journal Title

      Neuromuscul Disord 15(6)

      Pages: 416-426

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 肝細胞増殖因子(HGF)2005

    • Author(s)
      大谷若菜, 船越 洋, 中村敏一
    • Journal Title

      日本臨床 63

      Pages: 116-122

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of fukutin deficiency in the developing mouse.2005

    • Author(s)
      Chiyonobu T, Sasaki J, Nagai Y, Takeda S, Funakoshi H, Nakamura T, Sugimoto T, Toda T
    • Journal Title

      Neuromuscul Disord 15

      Pages: 416-426

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Inhibition of apoptosis-inducing factor protective effects of hepatocyte growth factor death in cultured hippocampal neurons.2005

    • Author(s)
      Ishihara N, Takagi N, Niimura M, Takagi K, Nakano M, Tanonaka K, Funakoshi H, Matsumoto K, Nakamura T, Takeo S
    • Journal Title

      J Neurochem 95

      Pages: 1277-1286

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Anxiolytic effect of hepatocyte growth factor.2005

    • Author(s)
      Isogawa K, Akiyoshi J, Kodama K, Matsushita H, Tsutsumi T, Funakoshi H, Nakamura T
    • Journal Title

      Neuropsychobiology 51

      Pages: 34-38

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Expression of hepatocyte growth factor in rat skeletal muscle.2005

    • Author(s)
      Tanaka S, Tanaka J, Kawahara E, Funakoshi H, Nakamura T, Tachino K
    • Journal Title

      J Phys Ther Sci 17

      Pages: 109-113

    • NAID

      10016945664

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Hepatocyte growth factor (HGF)2005

    • Author(s)
      Ohya W, Funakoshi H, Nakamura T
    • Journal Title

      Nihon Ronsho 63

      Pages: 116-122

    • NAID

      10005546016

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Anxiolytic effect of hepatocyte growth factor infused into rat brain.2005

    • Author(s)
      K.Isogawa et al.
    • Journal Title

      Neuropsychobiology 51

      Pages: 34-38

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Inhibition of apoptosis-inducing factor translocation is involved in protective effects of hepatocyte growth factor against excitotoxic cell death in cultured hippocampal neurons.2005

    • Author(s)
      Ishihara N et al.
    • Journal Title

      J.Neurochem. 319(4)

      Pages: 1277-1286

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Novel therapeutic strategy for stroke in rats by bone marrow stromal cells and ex vivo HGF genetransfer with HSV-1 vector.2005

    • Author(s)
      M.Z.Zhao et al.
    • Journal Title

      J.Cereb.Blood Flow Metab. 18

      Pages: 1-13

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Expression of Hepatocyte Growth Factor in Rat Skeletal Muscle.2005

    • Author(s)
      Tanaka S et al.
    • Journal Title

      J Phys Ther Sci. 17

      Pages: 109-113

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effects of fukutin deficiency in the developing mouse brain.2005

    • Author(s)
      T.Chiyonobu et al.
    • Journal Title

      Neuromusclar Disorders 15

      Pages: 416-426

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 肝細胞増殖因子(HGF)2005

    • Author(s)
      大谷若菜他
    • Journal Title

      広範囲血液・尿化学検査免疫学的検査(日本臨床社(東京)) 第6版

      Pages: 116-122

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Hepatocyte growth factor : from diagnosis to clinical applications.2005

    • Author(s)
      Mizuno S.
    • Journal Title

      FASEB J. (In press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Intrathecal injection of HVJ-E containing HGF gene to cerebrospinal fluid can prevent and ameliorate hearing impairment in rats.2004

    • Author(s)
      Oshima K, Shimamura M, Mizuno S, Tamai K, Doi K, Morishita R, Nakamura T, Kubo T, Kaneda Y.
    • Journal Title

      FASEB J. 8(1)

      Pages: 212-214

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Intrathecal injection of HVJ-E containing HGF gene can prevent and ameliorate hearing impairment in rats.2004

    • Author(s)
      Oshima K, Shimamura M, Mizuno S, Tamai K, Doi K, Morishita R, Nakamura T, Kubo T, Kaneda Y
    • Journal Title

      FASEB J 18

      Pages: 212-214

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Anxiolytic effect of hepatocyte growth factor infused into rat brain.2004

    • Author(s)
      Isogawa K.
    • Journal Title

      Neuropsychobiology 51(1)

      Pages: 34-38

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Hepatocyte growth factor attenuates cerebral ischemia-induced learning dysfunction.2004

    • Author(s)
      Date I.
    • Journal Title

      Biochem Biophys Res Commun. 319(4)

      Pages: 1152-1158

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Hepatocyte growth factor improved learning and memory dysfunction of microsphere-embolized rats.2004

    • Author(s)
      Date I.
    • Journal Title

      J Neurosci Res. 78(3)

      Pages: 442-445

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Intrathecal injection of HVJ-E containing HGF gene to cerebrospinal fluid can prevent and ameliorate hearing impairment in rats.2004

    • Author(s)
      Oshima K.
    • Journal Title

      FASEB J. 18(1)

      Pages: 212-214

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Bi-directional regulation of Ser-985 phosphorylation of c-met via protein kinase C and protein phosphatase 2A involves c-Met activation and cellular responsiveness to hepatocyte growth factor.2004

    • Author(s)
      Hashigasako A.
    • Journal Title

      J.Biol.Chem. 279(25)

      Pages: 26445-26452

    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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