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Compartmental organization and integration of inputs in the cerebellar nuclei

Research Project

Project/Area Number 16500259
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurophysiology and muscle physiology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

SUGIHARA Izumi  Tokyo Medical and Dental University, Department of Systems Neurophysiology, Associate Professor, 大学院・医歯学総合研究科, 助教授 (60187656)

Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2005: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2004: ¥1,900,000 (Direct Cost: ¥1,900,000)
KeywordsCerebellum / Cerebellar nucleus / aldolase C / zebrin / climbing fiber / inferior olive / neuroanatomy / rat / ビオチン化デキストラン / 小胞核
Research Abstract

The cerebellum is concerned with the control of various kinds of movements, suggesting precise functional compartmentalization in it. Our previous studies revealed that the aldolase C expression pattern in the cerebellar cortex is tightly related with its functional compartmentalization. Purkinje cell axons, which are the output of the cerebellar cortex, project to the cerebellar nuclei. Compared to the cerebellar cortex, the cerebellar nuclei have not been much studied in terms of the input and output neuronal circuits and the functional compartmentalization.
In the cerebellar nuclei, aldolase C is expressed in the terminals of Purkinje cell axons. Therefore, I first reconstructed aldolase C-positive and negative areas in the cerebellar nuclei in the three-dimensional space in the rat. This revealed that the aldolase C-negative and positive areas are each collected in the rostrodorsal, and caudoventral and lateral parts of the cerebellar nuclei.
To relate these areas to the olivary projection, I mapped the nuclear collateral terminations of olivocerebellar axons in three-dimensional space in the rat. This revealed very precise topography in the nuclear projection olivary axons. Based on the topography, the functional compartmentalization in the cerebellar cortex is preserved nearly exactly in the cerebellar nuclei. This supported our hypothesis about the functional significance of aldolase C compartmentalization, and suggests that the rostrodorsal part of the cerebellar nuclei (aldolase C-negative) may be concerned with somatosensory-related functions and the caudoventral and lateral part of the cerebellar nuclei (aldolase C-positive) are concerned with other functions.
Furthermore, labeled Purkinje cells projections indicated that the closed-loop circuit between the inferior olive and cerebellar cortex and nuclei was generally formed. Thus, precise compartmentalization and integration of neuronal inputs in the cerebellar nuclei were revealed.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (23 results)

All 2006 2005 2004 Other

All Journal Article (21 results) Book (2 results)

  • [Journal Article] Olivocerebellar modulation of motor cortex ability to generate vibrissal movements in rat.2006

    • Author(s)
      Lang, E.J., Sugihara, I., Llinas, R.
    • Journal Title

      J. Physiol., 541・1

      Pages: 101-120

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Organization and remodeling of the olivocerebellar climbing fiber projection.2006

    • Author(s)
      Sugihara, I.
    • Journal Title

      Cerebellum 5・1

      Pages: 15-22

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Olivocerebellar modulation of motor cortex ability to generate vibrissal movements in rat.2006

    • Author(s)
      Lang, E.J., Sugihara, I., Llinas, R.
    • Journal Title

      J.Physiol. 541(1)

      Pages: 101-120

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Organization and remodeling of the olivocerebellar climbing fiber projection.2006

    • Author(s)
      Sugihara, I.
    • Journal Title

      Cerebellum 5(1)

      Pages: 15-22

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Olivocerebellar modulation of motor cortex ability to generate vibrissal movements in rat.2006

    • Author(s)
      Lang, E.J.
    • Journal Title

      J.Physiol. 571・1

      Pages: 101-120

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Molecular, topographic, and functional organization of the cerebellar cortex : a study with combined aldolase C and olivocerebellar labeling.2005

    • Author(s)
      Sugihara, I., Shinoda, Y.
    • Journal Title

      J. Comp. Neurol., 487・1

      Pages: 93-106

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Microzonal projection and climbing fiber remodeling in single olivocerebellar axons of newborn rats at postnatal days 4-7.2005

    • Author(s)
      Sugihara, I.
    • Journal Title

      J. Comp. Neurol., 487・1

      Pages: 93-106

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 小脳の機能2005

    • Author(s)
      那杰, 杉原泉, 篠田義一
    • Journal Title

      Clinical Neuroscience 23・12

      Pages: 1361-1364

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Microzonal projection and climbing fiber remodeling in single olivocerebellar axons of newborn rats at postnatal days 4-7.2005

    • Author(s)
      Sugihara, I.
    • Journal Title

      J.Comp.Neurol. 487(1)

      Pages: 93-106

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Microzonal projection and climbing fiber remodeling in single olivocerebellar axons of newborn rats at postnatal days 4-7.2005

    • Author(s)
      Sugihara, I.
    • Journal Title

      J.Comp.Neurol. 487・1

      Pages: 93-106

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 小脳の機能2005

    • Author(s)
      那杰
    • Journal Title

      Clinical Neuroscience 23・12

      Pages: 1361-1364

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Functional compartmentalization in the flocculus and the ventral dentate and dorsal group y nuclei : an analysis of single olivocerebellar axonal morphology.2004

    • Author(s)
      Sugihara, I., Ebata, S., Shinoda.Y.
    • Journal Title

      J. Comp. Neurol. 470・2

      Pages: 113-133

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Functional compartmentalization in the flocculus and the ventral dentate and dorsal group y nuclei : an analysis of single olivocerebellar axonal morphology.2004

    • Author(s)
      Sugihara, I., Ebata, S., Shinoda.Y.
    • Journal Title

      J.Comp.Neurol. 470(2)

      Pages: 113-133

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Molecular, topographic, and functional organization of the cerebellar cortex : a study with combined aldolase C and olivocerebellar labeling.2004

    • Author(s)
      Sugihara, I., Shinoda, Y.
    • Journal Title

      J.Neurosci. 24(40)

      Pages: 8771-8785

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Functional compartinentalization in the flocculus and the ventral dentate and dorsal group y nuclei : An analysis of single olivocerebellar axonal morphology.2004

    • Author(s)
      Sugihara I, Ehata S, Shinoda, Y
    • Journal Title

      J.Comp.Neurol. 470.2

      Pages: 113-133

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Molecular, topographic and functional organization of the cerebellar cortex : a study with combined aldolase C and olivocerebellar labeling.2004

    • Author(s)
      Sugihara I, Shinoda, Y.
    • Journal Title

      J.Neurosci. 24.40

      Pages: 8771-8785

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Functional significance of aldolase C expression pattern in the cerebellar cortex in its relationship to the olivocerebellar projection.2004

    • Author(s)
      Sugihara I, Shinoda, Y.
    • Journal Title

      Neurosci.Res. 50.Suppl.

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Relationship between the olivocerebellar projection pattarn and the aldolase C expression map in thin rat cerebellar cortex.2004

    • Author(s)
      Sugihara, I., Shinoda, Y.
    • Journal Title

      Abstract Viewer/Itinerary Planner. Washington, DC : Society for Neuroscience 2004

    • Related Report
      2004 Annual Research Report
  • [Journal Article] The olivocerebellar system modulates motor cortex evoked whisker movements.2004

    • Author(s)
      Lang, E.J., Sugihara, I., Llinas, R.
    • Journal Title

      Abstract Viewer/Itinerary Planner. Washington, DC : Society for Neuroscience 2004

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Organization and remodeling of the olivocerebellar climbing fiber projection.

    • Author(s)
      Sugihara I
    • Journal Title

      Cerebellum (印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Microzonal projection and climbing fiber remodeling in single olivocerebellar axons of newborn rats at postnatal days 4-7.

    • Author(s)
      Sugihara, I.
    • Journal Title

      J.Comp.Neurol. (印刷中)

    • Related Report
      2004 Annual Research Report
  • [Book] 聴覚と平衡覚。人体の正常構造と機能、第9巻、神経系(2) (坂井建雄・河原克雅編)2005

    • Author(s)
      杉原泉
    • Publisher
      東京、日本医事新報社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 聴覚と平衡覚。人体の正常構造と機能、第9巻、神経系(2)(坂井建雄・河原克雅編)2005

    • Author(s)
      杉原 泉
    • Publisher
      東京、日本医事新報社
    • Related Report
      2005 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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