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Establishment of new inbred strains and development of useful model lines from the genetic resources of wild mice.

Research Project

Project/Area Number 16500275
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory animal science
Research InstitutionNagoya University

Principal Investigator

YAMAGATA Takahiro  Nagoya University, Graduate School of Bioagricultural Sciences, Assistant Professor, 大学院・生命農学研究科, 助手 (50242847)

Co-Investigator(Kenkyū-buntansha) ISHIKAWA Akira  Nagoya University, Graduate School of Bioagricultural Sciences, Associate Professor, 大学院・生命農学研究科, 助教授 (20211724)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2005: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2004: ¥1,900,000 (Direct Cost: ¥1,900,000)
Keywordswild mice / genetic resources / mutant / spontaneous disease model / congenic strain / recombinant inbred strains
Research Abstract

A purpose of this research is to discover useful mutant genes from genetic resources of wild mice, development of new spontaneous disease models from them and analyze their characteristic and heredity. We have established a new inbred line (CASP) from Philippine wild mice. And we discovered some mutants from the mating of the wild mice with existing inbred strains and bred them as lines. Research results provided during a research period are as follows. About a search of genetic characteristics of the new inbred strain, we performed polymorphism analysis using by microsatellite markers. As a result, it was different from that of existing inbred strains greatly and we confirmed it is useful for genetic analysis of the mutants discovered. About a breeding of mutant lines, an inbred line expressed stable hyperglycemia was established as an non-insulin dependent diabetes mellitus model by a selective inbreeding. We make a mating panel with this line and an existing inbred strains, and then … More we will perform genetic analysis about this hyperglycemia factor. Morphosis abnormality mice have been bred as a congenic line and we can go ahead with a goal of inbreeding. We investigated characteristics of these lines and it was predicted that they were new mutants which were not reported. About body size variant lines, we performed a functional analysis and refinement of candidate genes about mapped quantitative trait loci (QTLs) concerning body weight and growth of mice by making congenic strains. We reported the characteristic and expression patterns of these QTLs as novel genes influenced weight difference. About development and breeding of new recombinant inbred (RI) strains by mating between subspecies, we started the mating between CASP and BALB/cA strains and have been bred each of more than 15 lines from two F1 pairs with reciprocal mating. However, as reproductive performance fell off in many lines between F several and F ten and several generations, it is difficult to establish more than 20 lines in total as inbred strains finally. This cause investigation and measures are future examination problems. Less

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (16 results)

All 2006 2005 2004 Other

All Journal Article (16 results)

  • [Journal Article] Detection of quantitative trait loci causing abnormal spermatogenesis and reduced testis weight in the small testis (Smt) mutant mouse.2006

    • Author(s)
      Hasbaira, B. et al.
    • Journal Title

      Experimental Animals 55(2)

      Pages: 97-108

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Detection of quantitative trait loci causing abnormal spermatogenesis and reduced testis weight in the small testis mutant (Smt) mouse.2006

    • Author(s)
      Hasbaira, B. et al.
    • Journal Title

      Expelimental Animals 55(2)(in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Arrest of spermatogenesis at the early meiotic stage in the small testis mutant (Smt) mice.2005

    • Author(s)
      Hasbaira, B. et al.
    • Journal Title

      Experimental Animals 54(4)

      Pages: 327-337

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Further mapping of quantitative trait loci for postnatal growth in an inter subspecific backcross of wild Mus musculus castaneus and C57BL/6J mice.2005

    • Author(s)
      Ishikawa, A. et al.
    • Journal Title

      Genetic Researches Camb. 85

      Pages: 127-137

    • NAID

      120000976523

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Quantitative trait loci for glomerulosclerosis, kidney weight and body weight in the focal glomerulosclerosis mouse model.2005

    • Author(s)
      Kim,.-H.et al.
    • Journal Title

      Experimental Animals 54(4)

      Pages: 319-325

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Quantitative trait loci for proteinuria in the focal glomerulosclerosis mouse model.2005

    • Author(s)
      Kim,.-H.et al.
    • Journal Title

      Mammalian Genome 16

      Pages: 242-250

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Further mapping of quantitative trait loci for postnatal growth in an intersubspecific backcross of wild Mus musculus castaneus and C57BL/6J mice.2005

    • Author(s)
      Ishikawa, A. et al.
    • Journal Title

      Genetic Researches Camb. 85

      Pages: 127-137

    • NAID

      120000976523

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Quantitative trait loci for glomerulosclerosis, kidney weight and body weight in the focal glomerulosclerosis mouse model.2005

    • Author(s)
      Kim, E.-H.et al.
    • Journal Title

      Experimental Animals 54(4)

      Pages: 319-325

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Quantitative trait loci for proteinuria in the focal glomerulosclerosis mouse model.2005

    • Author(s)
      Kim, E.-H.et al.
    • Journal Title

      Mammalian Genome 16

      Pages: 242-250

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Arrest of spermatogenesis at the early meiotic stage in the small testis mutant (Smt) mice.2005

    • Author(s)
      Hasbaira, B. et al.
    • Journal Title

      Expelimental Animals 54(2)

      Pages: 327-337

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Further mapping of quantitative trait loci for postnatal growth in an intersubspecific backcross of wild Mus musculus castaneus and C57BL/6J mice.2005

    • Author(s)
      Ishikawa, A. et al.
    • Journal Title

      Genetic Researches Camb 85

      Pages: 127-137

    • NAID

      120000976523

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Quantitative trait loci for glomerulosclerosis, kidney weight and body weight in the focal glomerulosclerosis mouse model.2005

    • Author(s)
      Kim, E.-H.et al.
    • Journal Title

      Expelimental Animals 54(4)

      Pages: 319-325

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Mapping major quantitative trait loci for postnatal growth in an intersubspecific backcross between C57BL/6J and Philippine wild mice by using principal component analysis.2004

    • Author(s)
      Ishikawa, A., Namikawa, T
    • Journal Title

      Genes & Genetic Systems 79

      Pages: 27-39

    • NAID

      130000062099

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Mapping major quantitative trait loci for postnatal growth in an intersubspecific backcross between C57BL/6J and Philippine wild mice by using principal component analysis.2004

    • Author(s)
      Ishikawa, A., Namikawa, T.
    • Journal Title

      Genes & Genetic Systems 79

      Pages: 27-39

    • NAID

      130000062099

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Mapping major quantitative trait loci for postnatal growth in an intersubspecific backcross between C57BL/6J and Philippine wild mice by using principal component analysis.2004

    • Author(s)
      Ishikawa, A., Namikawa, T.
    • Journal Title

      Genes Genet.Syst. 79

      Pages: 27-39

    • NAID

      130000062099

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Quantitative trait loci for proteinuria in the focal glomerulosclerosis mouse model.

    • Author(s)
      Kim, E.-H.et al.
    • Journal Title

      Mammalian Genome (accepted)

    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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