| Project/Area Number |
16500290
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tokyo Medical and Dental University (2005)
Nagoya University (2004) |
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Principal Investigator |
TAKATANI Setsuo (2005) Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Professor, 生体材料工学研究所, 教授 (40154786)
吉川 雅治 (2004) 名古屋大学, 医学部附属病院, 講師 (80345892)
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| Co-Investigator(Kenkyū-buntansha) |
OHUCHI Katsuhiro Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Research Associate, 生体材料工学研究所, 助手 (20322084)
HOSHI Hideo Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Technologist, 生体材料工学研究所, 支援研究推進員 (30420251)
KATAOKA Hiroyuki Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Post Doctoral Fellow, 生体材料工学研究所, 機関研究員 (90397000)
高谷 節雄 東京医科歯科大学, 生体材料工学研究所, 教授 (40154786)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2005: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2004: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | Ventricular Assist Device / Centrifugal Blood Pump / Circuit Priming Volume / Heart Lung Machine / Extracorporeal Circulation / 小児補助循環 / 小児人工心肺 / 小児ECMO / 小児左心補助循環 / 数値流体解析 / 溶血指数 / 血栓 / 小児 / 重症心不全 / 遠心ポンプ / 溶血試験 / 生体適合性 / マグネットカップリング / マグネットサスペンジョン |
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| Research Abstract |
In this research, we have designed and tested a tiny centrifugal blood pump, TinyPUmp, intended for mechanical circulatory support of pediatric patients with the body weight ranging from 3 to 15 Kg. The TinyPump had the 30mm diameter impeller with 6 straight vanes supported by a hydrodynamic bearing at its center and driven by a magnetic coupling force between the external driver magnet and the follower magnet inside the impeller. The pump had the dimensions of 49mm external diameter, 42mm height including the motor driver, priming volume of 5 ml and 1/4 inch size inflow and outflow port. When the TinyPump was connected to the aorta of a 20 Kg piglet using the pediatric outflow cannlua of 2.6, 3.0 and 4.0 mm size, a stable low flow control down to 0.1 L/min was easily demonstrated. In another study, when the TinyPump was used to support both the lungs and heart of 3.0-3.5 Kg new born piglets, it showed improvement in hemodynamic and inflammatory responses incomparison to the clinical used Medtronic Bio-Pump BP-50. The TinyPump with extremely small priming volume of 5 ml, the total circuit prime including the pediatric oxygenator (Terumo Bany-RX) became only 68 ml in comparison to 118 ml of the Medtronic Bio-Pump BP-50. It was thus shown that the TinyPump because of its extremely small priming volume of 5 ml can be a potential candidate for open heart surgery in the pediatric patients to minimize complications such as infection and inflammatory responses due to blood transfusion and to improve the surgical outcomes.
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