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Detection of emboli in-vivo using high accuracy electrical impedance measurements

Research Project

Project/Area Number 16500300
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionKitasato University

Principal Investigator

SATORU Nebuya  Kitasato University, School of Allied and Health Sciences, Clinical Engineering, Lecturer, 医療衛生学部, 講師 (00276180)

Co-Investigator(Kenkyū-buntansha) NOSHIRO Makoto  Kitasato University, School of Allied and Health Sciences, Clinical Engineering, Professor, 医療衛生学部, 教授 (80014231)
Project Period (FY) 2004 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2006: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2005: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2004: ¥2,400,000 (Direct Cost: ¥2,400,000)
Keywordselectrical impedance / the common carotid artery / clot / non-invasive measurement / the finite element method / emboli detection / high accuracy / 電機インピーダンス / 頚動脈 / 導電率差 / 周波数特性 / 全血と凝固血液 / FEM / Bluetooth / 無線通信 / 高周波 / 頸部ファントム / 栓子 / 3D頸部モデル
Research Abstract

Doppler ultrasound has been used for the detection of emboli passing into the brain in order to forecast transient ischemic attacks, brain infarction and stroke. However, the Doppler ultrasound method has some disadvantages such as the attachment of an ultrasound transducer and maintenance of its direction. Electrical impedance measurement is a possible method for the in vivo detection of emboli and may overcome some of the disadvantages of the Doppler ultrasound method. However, the change in impedance caused by a bubble is expected to be very small and of short duration so that in vivo detection will be difficult. In this study, we had developed measurement techniques to detect emboli in vitro. The results of our study are as follows.
1. Development of an optically isolated impedance measurement system with high accuracy and speed.
We had suggested an optically isolated impedance measurement system. The system can measure real and imaginary components at 1.25MHz during 1ms. Transfer im … More pedance measurement accuracy was 0.1% at 1.25MHz. In addition, communication performance of Bluetooth module was also evaluated. The communication error was 0% at less than 30m of communication distance that is feasible for clinical use.
2. Development of electrical phantom of the neck and detection of emboli at the carotid model within the phantom.
The neck phantom consisted of materials to simulate the conductivity of skin, fat and muscle layers and a tube mimicking the common carotid artery. The whole model was a cube, 250x250x250 mm. Two disc drive electrodes of 3.5 mm in diameter were located 70 mm apart in a vertical linear array and two receive electrode were located 10mm apart in contact with the top of the skin layer. The measurement frequency was set at 100 kHz. Whole of Bovine blood had been filled into the carotid model and a 5mm cubic clot had also insulated into the center of the carotid model. The maximum impedance change was 0.12±0.16%.
3. Estimation of impedance change by passing through emboli using the lead field theory
The lead field theory developed by Geselowitz (1971) was used to calculate the theoretical impedance change as a function of the distance between the emboli and the electrode array for a homogenous phantom. We had also measured frequency characteristics of conductivity between whole of blood and clot of ten pigs to estimate absolute impedance change by passing thorough emboli with the theoretical function. Using the lead field theory and experimental results, the fundamental limit on the detectable size of emboli has been estimated for the common carotid artery. The theoretical results showed that a 0.5mm diameter emboli is detectable at a depth of 25mm, similar to the depth of the common carotid artery. Less

Report

(4 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (22 results)

All 2006 2005 2004

All Journal Article (22 results)

  • [Journal Article] Study of the optimum level of electrode placement for the evaluation of absolute lung resistivity with the Mk3.5 EIT system2006

    • Author(s)
      Satoru Nebuya et al.
    • Journal Title

      Physiological Measurement 27

      Pages: 129-137

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Comparison of absolute lung resistivity measured by using EIT between normal male, female and athlete subjects2006

    • Author(s)
      Satoru Nebuya et al.
    • Journal Title

      Proceedings of 7th Conference on Biomedical Applications of Electrical Impedance Tomography 7

      Pages: 90-90

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 電気インピーダンスCTを用いた肺抵抗率および換気量波形の推定2006

    • Author(s)
      根武谷 吾 他
    • Journal Title

      第21回生体・生理工学シンポジウム論文集 21

      Pages: 319-320

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 電気インピーダンス法による頸部電気ファントム中の栓子検出の試み2006

    • Author(s)
      根武谷 吾 他
    • Journal Title

      第21回生体・生理工学シンポジウム論文集 21

      Pages: 321-322

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 電気インピーダンスCTを用いた肺抵抗率測定のための電極配置2006

    • Author(s)
      根武谷 吾 他
    • Journal Title

      日本生体医工学会誌生体医工学 44-S1

      Pages: 349-349

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Study of the optimum level of electrode placement for the evaluation of absolute lung resistivity with the Mk3.5 EIT system2006

    • Author(s)
      Satoru Nebuya et al.
    • Journal Title

      Physiological Measurement April(In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Detection of emboli in vessels using electrical impedance measurements : phantom and electrodes2005

    • Author(s)
      Satoru Nebuya et al.
    • Journal Title

      Physiological Measurement 26

      Pages: 111-118

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] 肝腫瘍焼灼における電極配置と温度分布シミユレーション2005

    • Author(s)
      木浦千夏子, 根武谷吾 他
    • Journal Title

      医科器械学 75-12

      Pages: 837-844

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 人工股関節ステムの最適応力分布-有限要素解析と応力分布測定による各種ステムの評価-2005

    • Author(s)
      酒井利奈, 糸満盛憲, 根武谷吾, 馬淵清資
    • Journal Title

      バイオメカニズム学会誌 29-4

      Pages: 210-218

    • NAID

      110004820306

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] 特徴的な形状を有する人工股関節ステムにおける制動能の比較2005

    • Author(s)
      酒井利奈, 糸満盛憲, 根武谷吾, 馬淵清資
    • Journal Title

      バイオメカニズム学会誌 29-4

      Pages: 219-226

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] Simulation of temperature distribution for various electrode configuration in radiofrequency ablation for the liver cancer2005

    • Author(s)
      Chikako Konoura, Satoru Nebuya et al.
    • Journal Title

      Journal of the Japanese Society of Medical Instrumentation 75-12

      Pages: 837-844

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Appropriate stress distribution on a hip prosthesis -Assessments of different kinds of stems by measurements and FEM analysis-2005

    • Author(s)
      Rina Sakai, Moritoshi Itoman, Satoru Nebuya et al.
    • Journal Title

      Journal of the Society of Biomechanisms 29-4

      Pages: 210-218

    • NAID

      110004820306

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Comparisons of fixation stiffness of some hip stems with specific geometries2005

    • Author(s)
      Rina Sakai, Moritoshi Itoman, Satoru Nebuya et al.
    • Journal Title

      Journal of the Society of Biomechanisms 29-4

      Pages: 219-226

    • NAID

      110004820307

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 肝腫瘍焼灼における電極配置と温度分布シミュレーション2005

    • Author(s)
      木浦千夏子, 根武谷吾 他
    • Journal Title

      医科器械学 75-12

      Pages: 837-844

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Optimal configuration of ring-shaped electrodes for detecting emboli by impedance -analysis using the finite element method-2005

    • Author(s)
      Satoru Nebuya et al.
    • Journal Title

      6th Asian-Pacific Conference on Medical and Biological Engineering (in Tsukuba, Japan) 6

      Pages: 139-140

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Detection of emboli in vessels using electrical impedance measurements : phantom and electrodes2005

    • Author(s)
      Satoru Nebuya
    • Journal Title

      Physiological Measurement April(In press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Optimal configuration of ring-shaped electrodes for detecting emboli by impedance -analysis using the finite element method-2005

    • Author(s)
      Satoru Nebuya
    • Journal Title

      6th Asian-Pacific Conference on Medical and Biological Engineering (in Tsukuba, Japan) April(発表予定)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Study of the optimum level of electrode placement for the evaluation of absolute lung impedance with Mk3.5 EIT system2005

    • Author(s)
      Satoru Nebuya
    • Journal Title

      6th Conference on Biomedical Applications of Electrical Impedance Tomography (in London, UK) June(発表予定)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Estimation of the size of air emboli detectable by electrical impedance measurement2004

    • Author(s)
      Satoru Nebuya et al.
    • Journal Title

      Medical & Biological Engineering & Computing 42

      Pages: 142-144

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Estimation of the size of air emboli detectable by electrical impedance measurement2004

    • Author(s)
      Satoru Nebuya
    • Journal Title

      Medical & Biological Engineering & Computing 42

      Pages: 142-144

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 凝固による血液の電気インピーダンス変化の検討2004

    • Author(s)
      根武谷 吾
    • Journal Title

      第41回日本エム・イー学会抄録・論文集 43

      Pages: 502-502

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 電気インピーダンス法を用いた頸部血管ファントム内の栓子検出2004

    • Author(s)
      根武谷 吾
    • Journal Title

      第17回生体・生理工学シンポジウム論文集 19

      Pages: 177-178

    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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