| Project/Area Number |
16500304
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
TOMIZAWA Yasuko Tokyo Women's Medical University, Dept of Cardiovascular Surgery, Instructor, 医学部, 助手 (00159047)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2005: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2004: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | angiogenesis / scaffold / reconstruction / collagen / artificial organ / biomaterial / cytokine / wound healing / 組織親和性 / 細胞親和性 |
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| Research Abstract |
It is well known that collagen is a biocompatible material, however commercially available collagen hemostats are not equally made and cell affinity is different between the products.
For natural wound healing, the combination of cells, cytokines and scaffolds are the important factors to accelerate the healing. During angiogenesis in wound healing in a rabbit ear chamber model, angiogenesis was accelerated with cotton type atelo-collagen fiber, and recombinant human basic fibroblast growth factor (rhbFGF). We hypothesized that collagen fiber might absorb rhbFGF and worked as functional scaffold. This combination work in vivo, we could apply this into artificial organs and biomaterials to obtain angiogenesis and tissue reconstruction, as we plan.
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