| Project/Area Number |
16500326
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Kinki University |
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Principal Investigator |
KUDO Masatoshi Kinki University, School of Medicine, Professor, 医学部, 教授 (10298953)
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| Co-Investigator(Kenkyū-buntansha) |
MUNAKATA Hiroshi Kinki University, School of Medicine, Professor, 医学部, 教授 (90111294)
FUKUNAGA Toyokazu Kinki University, School of Medicine, Assistant Professor, 医学部, 講師 (90330315)
地挽 隆夫 GE横河メディカル超音波研究室, 室長
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2005: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2004: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | Hepatocellular Carcinoma / Dysplastic nodule / Pure arterial phase imaging / Nodule-in-nodule HCC / Vascular imaging / Early hepatocellular carcinoma / Arterial flow / Portal flow / nodule-in-nodule / Coded phase inversion harmonic / CD68 / Kupffer細胞 |
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| Research Abstract |
Hepatocarcinogenesis is a multistep process, evolving from a hyperplastic nodule to early HCC, through early overt HCC, eventually to advanced overt hypervascular HCC. During this process, changes in intranodular hemodynamics also occur. We clarified in this research that at the initial phase of carcinogenesis, the hemodynamic pattern shows arterial vascularity with hypovascular and portal perfusion (type I). In the next step, both arterial and portal blood supplies decrease (type II). Subsequently, intranodular arterial vascularity increases to isovascularity (type III), and then to hypervascularity (type IV). Another hemodynamic transition occurs from the initial pattern to nodule-in-nodule pattern (arterial vascularity with regional vascular spots in a hypovascular background of portal perfusion (type V).
Pure arterial phase imaging has been developed by a development of several technologies including Raw data management technology and accumulation image technology (MIP image). By this method, separate analysis of intranodular, portal flow from arterial flow has been possible, which is a novel technique. This was not possible by CT or MRI. Hepatocellular carcinoma, dysplastic nodule, and nodule-in-nodule type HCC can be successfully diagnosed by using this technique, pure arterial phase imaging.
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