The clinical research or repetitive transcranial magnetic stimulation for patients with movement disorders
| Project/Area Number |
16500331
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Hokkaido University |
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Principal Investigator |
CHUMA Takayo Hokkaido Univ., Hokkaido University Hospital, Inst., 病院, 助手 (70281805)
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| Co-Investigator(Kenkyū-buntansha) |
IKOMA Katsunori Hokkaido Univ., Hokkaido University Hospital, Prof., 教授 (70202918)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2005: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2004: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | repetitive trancranial magnetic stimulation / Parkinson's disease / dorsolateral prefrontal cortex / cortical mapping / stroop test / stroop test |
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| Research Abstract |
rTMS (repetitive transcranial magnetic stimulation) has been reported the effects for depression and central nervous disorders. In 2004, we studied the effect of rTMS using 13 patients with Parkinson's disease. We used a twin coil. The patients received low frequency rTMS (0.3Hz, 50 pulses, intensity ; 120% motor threshold) over the dorsolateral prefrontal cortex (DLPFC), the supplementary motor area (SMA), the premotor cortex and the primary motor cortex, compared to sham stimulation. We measured cortical mapping of the abductor pollicis brevis muscle (APB) before rTMS and after rTMS. The cortical mapping area after rTMS over DLPFC became larger and the MEP amplitude of APB became higher than those before rTMS. This suggests that rTMS over DLPFC induced cortical excitability. In 2005, we studied the effect of high frequency rTMS for patients with Parkinson's disease. The patients received 10Hz high frequency rTMS over the DLPFC and the primary motor cortex, compared to sham stimulation. We measured stroop test, gait pattern and grasping power. By the rTMS over the DLPFC, stroop test times became shorter than that before rTMS. Then high frequency rTMS over the DLPFC for patients with Parkinson's disease might induce the effect of frontal function.
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Report
(3 results)
Research Products
(5 results)
