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Prognostic study of the reattack of cerebral infarction by analyzing endothelial injury and platelet activation

Research Project

Project/Area Number 16500334
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionSaitama Medical School

Principal Investigator

KURABAYASHI Hitoshi  Saitama Medical School, Rehabilitation, Assoc.Prof, 医学部, 助教授 (70192036)

Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2005: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2004: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywordscerebral infarction / platelet / endothelial cell / insulin resistance / monocyte / atherosclerosis / motor function / respiratory function / 温熱療法 / 水治療
Research Abstract

We studied the association among endothelial function, platelet activation, monocyte activation, atherosclerosis, and thrombosis in order to evaluate the effect of therapeutic exercise and rehabilitation on the prevention of atherosclerosis and reattack of stroke. We reported previously that platelet activation in patients with stroke increased more than that in patients with hypertension, which increased more than that of healthy subjects, and concluded that platelet activation increased with atherosclerosis. We reported that insulin resistance associated closely with stroke and atherosclerosis. On the other hand, we reported that hyperthermal stress induced endothelial dysfunction and platelet activation, suggesting that hyperthermal stress results in thrombosis. These our previous reports accelerated us to further study the effect of therapeutic exercise on endothelial function, platelet activation, and monocyte activation. This study demonstrated a marked dysfunction of endothelial cells after stroke and a trend toward an improvement in endothelial function during therapeutic exercise or rehabilitation. Furthermore, our study showed a slight dysfunction of endothelial cells and a delayed manifestation of cerebral lesion in cerebral infarction not based on atherosclerosis. And disordered functions of endothelial cells and monocytes in patients with insulin resistance or metabolic syndrome were observed.
Taken together with our previous report that the rehabilitation improved not only motor function but also respiratory and immunological functions, the current study demonstrates that the rehabilitation would be associated with the prevention of atherosclerosis and stroke, besides the improvement in motor, respiratory, circulatory, immunological, and endocrinological functions.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (38 results)

All 2006 2005 2004

All Journal Article (34 results) Book (4 results)

  • [Journal Article] 湯治を現代医学で捉える2006

    • Author(s)
      倉林均
    • Journal Title

      臨床看護 32

      Pages: 729-736

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 真性多血症により脳梗塞を発症した1症例-動脈硬化を基盤にした脳梗塞との相違点-2005

    • Author(s)
      倉林均, 菱沼亜紀子, 間嶋満, 他
    • Journal Title

      リハビリテーション医学 42

      Pages: 883-889

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 慢性肺気腫における呼気訓練の臨床的効果2005

    • Author(s)
      倉林均, 田村耕成, 他
    • Journal Title

      日本温泉気候物理医学会雑誌 69

      Pages: 29-30

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] リハビリテーション医学における熱ショック蛋白質(2) 脳卒中片麻痺患者の骨格筋における健側と麻痺側の発見量の検討2005

    • Author(s)
      鶴川俊洋, 間嶋満, 倉林均
    • Journal Title

      リハビリテーション医学 42

      Pages: 895-896

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] メタボリックシンドロームを伴った外傷性頸髄損傷の1例.脊髄損傷で動脈硬化が惹起される機序に関する1考察2005

    • Author(s)
      間嶋満, 内田龍制, 倉林均, 他
    • Journal Title

      リハビリテーション医学 42

      Pages: 341-341

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 脳卒中患者のインスリン抵抗性に関与する因子の検討2005

    • Author(s)
      間嶋満, 倉林均
    • Journal Title

      リハビリテーション医学 42

      Pages: 250-251

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] 気候・気象が外来患者の主訴および疾患群に与える影響2005

    • Author(s)
      星野綾美, 田村遵一, 倉林均, 他
    • Journal Title

      日本温泉気候物理医学会雑誌 68

      Pages: 150-154

    • NAID

      10015686073

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A case report of cerebral infarction caused by polycythemia rubra vera ; Clinical difference from cerebral infarction based on atherosclerosis2005

    • Author(s)
      Kurabayashi H, et al.
    • Journal Title

      Jpn J Rehabil Med 42

      Pages: 888-889

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Clinical effect of breathing-out exercise in patients with chronic emphysema2005

    • Author(s)
      Kurabayashi H, et al.
    • Journal Title

      J Jpn J Soc Balneol Climatol Phys Med 69

      Pages: 29-30

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Clinical analysis for the factors associated with insulin resistance in patients with stroke2005

    • Author(s)
      Majima M, Kurabayashi H, et al.
    • Journal Title

      Jpn J Rehabil Med 42

      Pages: 250-251

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A case report of traumatic cervical cord injury with metabolic syndrome ; A hypothesis for the mechanism of atherosclerosis caused by spinal cord injury2005

    • Author(s)
      Majima M, Kurabayashi H, et al.
    • Journal Title

      Jpn J Rehabil Med 42

      Pages: 341-341

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Heat shock protein in rehabilitation medicine ; The level of heat shock protein in skeletal muscle of affected and unaffected lower extremities in hemiplegic patients with stroke2005

    • Author(s)
      Tsurukawa T, Kurabayashi H, et al.
    • Journal Title

      Jpn J Rehabil Med 42

      Pages: 895-896

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effect of weather on chief complaints and disorders of outpatients2005

    • Author(s)
      Hoshino A, Kurabayashi H, et al.
    • Journal Title

      J Jpn J Soc Balneol Climatol Phys Med 68

      Pages: 150-154

    • NAID

      10015686073

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 真性多血症により脳梗塞を発症した1症例-動脈硬化を基盤にした脳梗塞との相違点-2005

    • Author(s)
      倉林均, 菱沼亜紀子, 内田龍制 他
    • Journal Title

      リハビリテーション医学 42

      Pages: 888-889

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 慢性肺気腫における呼気訓練の臨床的効果2005

    • Author(s)
      倉林均, 田村耕成, 久保田一雄 他
    • Journal Title

      日本温泉気候物理医学会雑誌 69

      Pages: 29-30

    • Related Report
      2005 Annual Research Report
  • [Journal Article] リハビリテーション医学における熱ショック蛋白質(2) 脳卒中片麻痺患者の骨格筋における健側と麻痺側の発現量の検討2005

    • Author(s)
      鶴川俊洋, 間嶋満, 倉林均 他
    • Journal Title

      リハビリテーション医学 42

      Pages: 895-896

    • Related Report
      2005 Annual Research Report
  • [Journal Article] メタボリックシンドロームを伴った外傷性頸髄損傷の1例.脊髄損傷で動脈硬化が惹起される機序に関する1考察2005

    • Author(s)
      間嶋満, 内田龍制, 倉林均 他
    • Journal Title

      リハビリテーション医学 42

      Pages: 341-341

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 気候・気象が外来患者の主訴および疾患群に与える影響2005

    • Author(s)
      星野綾美, 田村遵一, 倉林均 他
    • Journal Title

      日本温泉気候物理医学会雑誌 68

      Pages: 150-154

    • NAID

      10015686073

    • Related Report
      2005 Annual Research Report
  • [Journal Article] platelet activation as a possible marker for cerebral infarction2004

    • Author(s)
      Hitoshi Kurabayashi, et al.
    • Journal Title

      Proc Japanese-Korean joint Conf Rehabil Med 2

      Pages: 134-134

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Continuing rehabilitation enhances immune function in cerebral infarction2004

    • Author(s)
      Hitoshi Kurabayashi, et al.
    • Journal Title

      Proc Japanese-Korean Joint Conf Rehabil Med 2

      Pages: 133-134

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Clinical effects of breathing-out-water exercise by head-out water immersion in patients with COPD2004

    • Author(s)
      Hitoshi Kurabayashi, et al.
    • Journal Title

      proc Japanese-Korean Joint Conf Rehabil Med 2

      Pages: 105-105

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 脳梗塞患者におけるインスリン抵抗性の発見に関与する因子の検討2004

    • Author(s)
      間嶋満, 牧田茂, 倉林均, 他
    • Journal Title

      リハビリテーション医学 41812)

      Pages: 893-893

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 加齢による呼吸機能と運動機能について、開胸術前評価による検討2004

    • Author(s)
      長谷川信, 倉林均, 他
    • Journal Title

      The Kitakanto Medical Journal 54

      Pages: 182-183

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 温熱の多面的効果を科学する.血液系・免疫系への効果.2004

    • Author(s)
      倉林均
    • Journal Title

      日本温泉気候物理医学会雑誌 68(1)

      Pages: 24-26

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Platelet activation as a possible marker for cerebral infarction2004

    • Author(s)
      Kurabayashi H, et al.
    • Journal Title

      Proc Japanese-Korean Joint Conf Rehabil Med 2

      Pages: 134-134

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Continuing rehabilitation enhances immune function in cerebral infarction2004

    • Author(s)
      Kurabayashi H, et al.
    • Journal Title

      Proc Japanese-Korean Joint Conf Rehabil Med 2

      Pages: 133-134

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Clinical effects of breathing-out-into-water exercise by head-out water immersion in patients with COPD2004

    • Author(s)
      Kurabayashi H, et al.
    • Journal Title

      Proc Japanese-Korean Joint Conf Rehabil Med 2

      Pages: 105-105

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Scientific research of many-sided effect of hyperthermia ; the effect of hematological and immunological systems2004

    • Author(s)
      Kurabayashi H
    • Journal Title

      J Jpn J Soc Balneol Climatol Phys Med 68

      Pages: 24-26

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Respiratory and motor functions by aging ; Clinical analysis by preoperative assessment of chest surgery2004

    • Author(s)
      Hasegawa M, Kurabayashi H, et al.
    • Journal Title

      Kitakanto Med J 54

      Pages: 182-183

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Platelet activation as a possible marker for cerebral infarction2004

    • Author(s)
      Hitoshi Kurabayashi, et al.
    • Journal Title

      Proc Japanese-Korean Joint Conf Rehabil Med 2

      Pages: 134-134

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Clinical effects of breathing-out-into-water exercise by head-out water immersion in patients with COPD2004

    • Author(s)
      Hitoshi Kurabayashi, et al.
    • Journal Title

      Proc Japanese-Korean Joint Conf Rehabil Med 2

      Pages: 105-105

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 脳梗塞患者におけるインスリン抵抗性の発現に関与する因子の検討2004

    • Author(s)
      間嶋満, 牧田茂, 倉林均, 他
    • Journal Title

      リハビリテーション医学 41(12)

      Pages: 893-893

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 加齢による呼吸機能と運動機能について.開胸術前評価による検討2004

    • Author(s)
      長谷川信, 伊東有紀子, 倉林均, 他
    • Journal Title

      The Kitakanto Medical Journal 54(2)

      Pages: 182-183

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 温熱の多面的効果を科学する.血液系・免疫系への効果2004

    • Author(s)
      倉林均
    • Journal Title

      日本温泉気候物理医学会雑誌 68(1)

      Pages: 24-26

    • Related Report
      2004 Annual Research Report
  • [Book] 温泉療法医教育研修会テキスト2005

    • Author(s)
      日本温泉気候物理医学会編
    • Total Pages
      120
    • Publisher
      JTB印刷
    • Related Report
      2005 Annual Research Report
  • [Book] 新温泉医学2004

    • Author(s)
      日本温泉気候物理医学学会編
    • Total Pages
      416
    • Publisher
      JTB印刷
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 温泉療法医教育研修会テキスト2004

    • Author(s)
      日本温泉気候物理医学学会編
    • Total Pages
      120
    • Publisher
      JTB印刷
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 新温泉医学2004

    • Author(s)
      日本温泉気候物理医学会編
    • Total Pages
      420
    • Publisher
      JTB印刷
    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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