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Effects of physical stimulations on regeneration of peripheral nerves and denervated muscle fibers

Research Project

Project/Area Number 16500342
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionKobe University

Principal Investigator

MIKI Akinori  Kobe University, School of Medicine, Professor, 医学部, 教授 (20144561)

Co-Investigator(Kenkyū-buntansha) ANDO Hiroshi  Kobe University, School of Medicine, Professor, 医学部, 教授 (30144562)
MATSUBARA Takako  Kobe University, School of Medicine, Assistant, 医学部, 助手 (30294234)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2005: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2004: ¥2,300,000 (Direct Cost: ¥2,300,000)
Keywordselectromagnetic stimulation / electrical stimulation / ultrasound stimulation / nerve regeneration / muscle regeneration / wound healing / 末梢神経 / 再生 / 脱神経 / 骨格筋 / 物理刺激 / 物理療法 / 関節可動域運動 / 廃用性筋萎縮 / マウス坐骨神経 / 免疫組織化学
Research Abstract

Effects of physical stimulations (electromagnetic stimulation, electric stimulation, ultrasound stimulation, stretch) on nerve and muscle regeneration and wound healing were morphologically and immunohistochemically investigated
1.Effects of physical stimulation on wound healing were morphologically studied in the injured mouse skin. Our findings suggest that ultrasound stimulation and electromagnetic stimulation promote the wound healing, but leaser irradiation was not effective.
2.When the stretch was applied soon after the eccentric exercise, muscle swelling and secondary degeneration at the injury site were lightened and muscle regeneration was promoted It has been said that one of the reasons for delayed onset muscle soreness (DOMS) might be the swelling of muscles occurring one or two days after the extensive exercise. The findings of the present study suggest that adequate stretch soon after the exercise might be useful to reduce the DOMS.
3.It has been widely accepted that electrical and electromagnetic stimulation promotes peripheral nerve regeneration, and also that macrophages and Schwann cells play important role for nerve regeneration. In the present study, influence of electromagnetic stimulation on expression of nerve growth factor (NGF) in the injured sciatic nerve was immunohistochemically investigated. When the electromagnetic stimulation was applied one day after the injury, expression of NGF at the injury site increased. Electron microscopically, immunoreaction for NGF was detected in the cytoplasm of Schwann cell and fibroblasts and along the basal lamina of Schwann cells.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (8 results)

All 2005 2004 Other

All Journal Article (8 results)

  • [Journal Article] Effects of stretch on muscle regeneration in the damaged mouse soleus muscle after eccentric exercise.2005

    • Author(s)
      T.Matsubara, A.Miki
    • Journal Title

      Bull. Health Sciences Kobe 21

      Pages: 1-11

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of stretch on muscle regeneration in the damaged mouse soleus muscle after eccentric exercise.2005

    • Author(s)
      Matsubara T, Miki A
    • Journal Title

      Bull Health Sciences Kobe 21

      Pages: 1-11

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of stretch on muscle regeneration in the damaged mouse soleus muscle after eccentric exercise2005

    • Author(s)
      T Matsubara
    • Journal Title

      Bull.Health Sci.Kobe 21(in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 皮膚組織修復における物理刺激の有効性2004

    • Author(s)
      篠原英記, 小形晶子, 三木明徳
    • Journal Title

      理学療法 21・11

      Pages: 1349-1357

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of physical stimulation on wound healing in the injured mouse skin (in Japanese)2004

    • Author(s)
      Shinohara H, Ogata A, Miki A
    • Journal Title

      Rigakuryouhou 21(11)

      Pages: 1349-1357

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 皮膚組織修復における物理療法の有効性2004

    • Author(s)
      篠原英記
    • Journal Title

      理学療法 21巻11号

      Pages: 1349-1357

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Repairing process in the transected muscle fibers of the mouse tibialis anterior.

    • Author(s)
      M.Matsumoto, T.Matsubara, A.Miki
    • Journal Title

      J. Physical Therapy (in press)

    • NAID

      10024170441

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Repairing process in the transected muscle fibers of the mouse tibialis anterior.

    • Author(s)
      Matsumoto M, Matsubara T, Miki A
    • Journal Title

      J.Physical Therapy (in press)

    • NAID

      10024170441

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary

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Published: 2004-04-01   Modified: 2016-04-21  

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