| Project/Area Number |
16500352
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | International University of Health and Welfare |
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Principal Investigator |
KATO Hiroyuki International University of Health and Welfare, Department of Health, Professor, 保健学部, 教授 (60224531)
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| Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Ritsuo International University of Health and Welfare, Department of Health, Professor, 保健学部, 教授 (50254917)
HIWATARI Masao International University of Health and Welfare, Graduate School, Professor, 大学院, 教授 (20189898)
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| Project Period (FY) |
2004 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2005: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2004: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | Functional MRI / Stroke / Hemiparesis / Functional recovery / Reorganization |
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| Research Abstract |
The mechanism of motor functional recovery after stroke is still largely unknown. The purpose of this study was to reveal various patterns of brain activation induced by paretic hand movement during motor recovery after stroke using functional MRI. We selected 21 stroke patients who suffered from mild to moderate hemiparesis. Functional MRI was performed during a task of unilateral hand movement within 28 days of stroke onset and again at least one month later. Nine control subjects were also included. Normal hand movements activated predominantly contralateral primary sensorimotor cortex, supplementary motor areas, and ipsilateral cerebellum. At acute/subacute stages after stroke (15±9 days after onset), activations in these typical motor cortical areas were reduced, with or without activation in additional motor-related areas, such as ipsilateral primary motor cortex and contralateral parietal cortex. At chronic stages (46±16 days after onset), activities in the typical motor areas were restored in many patients. Activation in additional motor-related areas was decreased, persisted or appeared late. The findings suggest that motor functional recovery occurred primarily using the original motor system when damage to it was mild or reversible, recruiting related motor sites transiently or persistently, and that motor reorganization occurred when the damage was not small and irreversible. These restorative and reorganizing processes occurred predominantly within the first 1 to 2 months, and this period seemed critical to motor functional recovery.
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