| Project/Area Number |
16500372
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Tokyo Metropolitan Organization for Medical Research |
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Principal Investigator |
NEMOTO Masahito Tokyo Metropolitan Organization for Medical Research, Tokyo Institute of Psychiatry, Integrated Neuroscience, Researcher, 東京都精神医学総合研究所, 研究員 (80370980)
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| Co-Investigator(Kenkyū-buntansha) |
HOSHI Yoko Tokyo Metropolitan Organization for Medical Research, Tokyo Institute of Psychiatry, Integrated Neuroscience, Team leader, 東京都精神医学総合研究所, 副参事研究員 (50332383)
TERAKAWA Susumu Hamamatsu University School of Medicine, Photon Medical Research Center, Professor, 光量子医学研究センター, 副学長・教授 (50014246)
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| Project Period (FY) |
2004 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2006: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2005: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2004: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | Optical Intrinsic Signals / Photochemical Thrombosis / Neurovascular Coupling / Neural Plasticity / Reorganization / Brain Mapping / Functional Recovery / Functional Near-Infrared Spectroscopy |
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| Research Abstract |
Our research aim is to investigate relationships among neural activity, blood flow, metabolism and functional recovery during activation of impaired brain function.
1.We first set up automated systems that we could simultaneously measure neural activity (local field potential, LFP, and multiunit activity, MUA) and activity-related hemodynamic responses by imaging of intrinsic signals derived from changes in oxy- and deoxyhemoglobin concentration in rat cerebral cortex during sensory stimulation under chloralose /or isoflurane anesthesia.
2.We applied the systems to a study of unimpaired neurovascular coupling. To investigate how faithfully hemodynamic responses reflect neural interactions in complex stimulation paradigms, we delivered electrical stimulation pulses to contra-and/or ipsilateral rat hindpaw, and simultaneously measured neural (LFP<100Hz, MUA>300Hz) and hemodynamic responses in rat somatosensory cortices. The results are as follows. We observed both neural and hemodynamic si
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gnal responses in the bilateral primary somatosensory areas while applying unilateral stimulation, and we found the medio-caudal shift of the ipsilateral CBV responses relative to the contralateral responses, different-slope linearities in the LFP-MUA relationships, and different transfer functions from neural to hemodynamic signals between the contra-and ipsilateral responses. While applying bilateral stimulation with varying time lags, both neural and hemodynamic signals were strongly suppressed at 40 and 60 ms time-lags, but the hemodynamic signals were slightly enhanced without increases in the neural signals during simultaneous bilateral stimulation. We also found several types of non-linearities in the relationships among LFP, MUA and CBV responses associated with signal genesis and analysis methodology.
3.Now we are investigating neurovascular coupling in a pathological state. We introduced local cerebral ischemia with photochemical thrombosis of feeding arteries supplying the somatosensory cortex with blood. Then we are measuring neural and hemodynamic responses to sensory stimulation. We have not yet reached a clear conclusion. Less
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