| Budget Amount *help |
¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2005: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2004: ¥900,000 (Direct Cost: ¥900,000)
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| Research Abstract |
Metabolic syndrome is a pathological condition that may cause vascular complications such as myocardial infarction and cerebral infarction. Accumulation of visceral fat is the most important causative factor and it is essential for its diagnosis by the Japanese criteria of metabolic syndrome. Recently we have reported that non-obese subjects (BMI < 25 kg/m^2) with visceral fat area measured by CT scan at the umbilical level are more than 100 cm2 show metabolic abnormalities similar to obese metabolic syndrome. This group is commonly called 'metabolically obese with normal-weight (MONW)'. In our study, the population was MONW subjects from Mihama town of Mie prefecture and the purpose of the study was to investigate influence on life style. We examined abdominal circumference and metabolic parameters before and after the modification of their diet and exercise.
Eight hundred and twenty nine people (male/female: 288/541) visited our diabetic examination in Mihama, and 32 men were selected as MONW subjects, but there were no women with MONW. We held a workshop about metabolic syndrome to perform an intervention program in life style. 7 MONW and 2 obese subjects were enrolled in this program. Before intervention, their life styles were examined. Energy expenditure, salt and iron intake were appropriate. However, protein and fat intake were excessive, and carbohydrate and dietary fiber and calcium intake were deficient. Furthermore, we investigated the details regarding fat intake, energy % of fat, saturated fatty acid intake, n3 and n6 fatty acid intake, all of them were found to be appropriate. This intervention program based on the above data is now in progress. Moreover, we are making all possible effort to increase the number of the subjects in MONW and obese metabolic syndrome group to elucidate whether the effect of improvement of metabolic abnormalities by modifying life style affects oxidative stress and the unbalanced adipokine network.
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