| Project/Area Number |
16500460
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Niigata University of Health and Welfare |
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Principal Investigator |
SAITO Toshiko Niigata University of Health and Welfare, Professor, 教授 (40339958)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Kazutoshi Niigata University of Health and Welfare, Graduate School of Medical and Dental Sciences, Associate Professor, 大学院・医歯学総合研究科, 助教授 (70207869)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2005: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2004: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | Bone mass / Environment / Genetic polymorphism / Growth / Interaction / Longitudinal study / Vitamin D receptor / Young women / 青年期女子 / 体格 / カルシウム / 運動 |
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| Research Abstract |
The purpose of this study was to clarify associations between environmental factors, genetic factors, and their possible interaction v s.bone mineral density (BMD) of young women. Apa 1 and Taq 1 polymorphisms of vitamin D receptor were analyzed by restriction fragment length polymorphism (RFLP) method. Bone mineral density at the lumbar spine and hip was measured by dual-energy X-ray absorptiometry. Lifestyles were assessed by interview. 1)BMD was cross-sectionally associated with body weight, grip strength, and serum intact parathyroid hormone concentrations. 2)BMD was predicted by weight gain in infancy and the prepubertal period. 3)Subjects with an "AA" genotype had greater decrease in BMD at the femoral neck than those with an "Aa" or "aa" genotype. However, no interactions between environmental factors v.s.vitamin D polymorphisms on BMD were found.
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