| Project/Area Number |
16500468
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | National Institute of Advanced Industrial Science and Technology (2007)
Tokyo Metropolitan Organization for Medical Research (2004-2006) |
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Principal Investigator |
SATO Chie National Institute of Advanced Industrial Science and Technology, AIST, Res, Inst. Of Instrumentation Frontier, Post-Doctoral Research Scientist (00356255)
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| Co-Investigator(Kenkyū-buntansha) |
HOSHI Yoko Tokyo Metropolitan Organization for Medical Research, Tokyo Institute of Psychiatry, Research Scientist (50332383)
IGUCHI Yoshinobu Tokyo Metropolitan Organization for Medical Research, Tokyo Institute of Psychiatry, Research Scientist (10342916)
NEMOTO Masahito Tokyo Metropolitan Organization for Medical Research, Tokyo Institute of Psychiatry, Research Scientist (80370980)
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| Project Period (FY) |
2004 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,280,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2006: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2005: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2004: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | brain, nerve / near infrared spectroscopy (NIRS) / mastication / cerebral blood flow change / aging / neuroscience / dementia / 計測工学 / 近赤外分光計測 / 認知・記憶 / 記憶 / 認知症(痴呆症) |
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| Research Abstract |
Recently, some researchers have reported the possibility that impairment of ability for mastication was one of the trigger factors of dementia. There are, however, only a few studies on the relationship between mastication and cognitive function. The aim of this study is to investigate the relationship between mastication and hemodynamics, which is the first step toward our health care and the prevention of some neurological diseases.
First, for selective monitoring of the cerebral perfusion, we studied some characteristics of optical signals measured from the human head by near-infrared spectroscopy(NIRS), which has some advantages over other methods in terms of, for example, the measurement under sitting on the seat. We clarified the usefulness and limitations of the NIRS(time-resolved spectroscopic method) for monitoring of cerebral hemodynamics.
Next, we examined Hb concentration changes evoked by chewing and cognitive tasks using NIRS By chewing, oxy-Hb increased in the temporal area(Brodmann's Area 9 and 46) and decreased in the region of parietal By doing verbal fluency task, decreases of oxy-Hb in the regions of the frontal and parietal were observed. We can suppose that there is a similarity of activation area between the two tasks.
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