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The proposal of eating habits reduced oxidative stress

Research Project

Project/Area Number 16500504
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionOchanomizu University

Principal Investigator

SUSUKI Emiko  Ochanomizu Univ., Fac.Human Life and Environ.Sciences, Assistant Professor, 生活科学部, 助教授 (80154524)

Co-Investigator(Kenkyū-buntansha) KURARTA Tadao  Nigata Univ., Pharmacy and Applied Life Sciences, Fac.Applied Life Sciences, Professor, 応用生命科学部, 教授 (60011920)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2005: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2004: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywordsoxidative stress / vitamin C
Research Abstract

Vitamin C (AsA) which is known as antioxidant, can be taken in from food. It is expected that the increase in AsA content in the body can prevent the development of symptoms of diseases caused by oxidative stress. However, there is few information of the behavior of AsA in the body. This study was done to clarify the AsA behavior in the body on the oxidative condition.
The tissue AsA concentration in streptozotocin-induced diabetic rats was higher than that of normal rats. However the TBA value of plasma of diabetic rats tended to be higher than that of normal rats. It is well known that xenobiotics promote active oxygen production. Furthermore, HepG2 cell was cultured with the medium added 3-metylchoranthrene (3-MC) and AsA, and AsA concentration of the HepG2 was measured. The concentration of AsA in the cells which were cultured with a medium added 3-MC tended to increase. It is assumed that oxidative stress stimulates the AsA uptake in the tissues. The blood of the rats exposed to pure oxygen was collected from vein and AsA plasma concentration was measured. Furthermore, the AsA concentrations and TBA value in the tissues were measured. The concentration of oxidized formed of AsA increased immediately after oxygen exposure, but remained constant after. On the other hand, there was no apparently change in the concentration of reduced-formed of AsA in the plasma. The concentration of reduced-formed of AsA in lungs of rats exposed to oxygen tended to be higher, but the oxidized-formed of AsA to be lower than those of rats not exposed... There was no significant difference in the content of 8-OHdG of lungs between oxygen exposed and not exposed rats. The TBA values of lungs in oxygen exposed rats were higher than those of not oxygen exposed rats.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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