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Study on metabolism in vivo mediated by gut hormone

Research Project

Project/Area Number 16500508
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionKyoto University

Principal Investigator

YAMADA Yuichiro  Kyoto University, Graduate School of Medicine, Associate Professor, 医学研究科, 助教授 (60283610)

Co-Investigator(Kenkyū-buntansha) FUSHIKI Tohru  Kyoto University, Graduate School of Agriculture, Professor, 農学研究科, 教授 (20135544)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2005: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2004: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywordsincretin / GIP / GLP-1 / diabetes / obesity / energy expenditure
Research Abstract

The hormonal factor(s) implicated as transmitters of signals from the gut to pancreatic β-cells is referred to incretin and gastric inhibitory polypeptide (GIP) is identified as one of the incretins. GIP is a gastrointestinal peptide hormone of 42 amino acids that is released from duodenal endocrine K-cells after absorption of glucose or fat and exerts its effects by binding to its specific receptor, the GIP receptors (GIPR). We have characterized mice with a targeted mutation of the GIPR gene and found that IRS-1(-/-)GIPR(-/-) mice exhibited both reduced adiposity and ameliorated insulin resistance, indicating GIP plays a crucial role in switching from fat oxidation to fat accumulation under the diminished insulin action as a potential target for secondary prevention of insulin resistance. Furthermore, bone histomorphometrical analyses revealed that bone formation parameters were significantly lower and that the number of osteoclasts was significantly increased, indicating that GIP receptor(-/-) mice have high-turnover osteoporosis. These results indicated that GIP has not only an insulinotropic role but also physiological roles on fat-accumulation into adipose tissues and calcium-accumulation into bone. We here propose a new acronym GIP for Gut-derived nutrient-Intake Polypeptide.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (17 results)

All 2006 2005 2004 Other

All Journal Article (17 results)

  • [Journal Article] Gastric inhibitory polypeptide as an endogenous factor promoting new bone formation after food ingestion.2006

    • Author(s)
      Tsukiyama K
    • Journal Title

      Mol Endocrinol (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Autoantibodies against the exocrine pancreas in fulminant type 1 diabetes2005

    • Author(s)
      Taniguchi T
    • Journal Title

      Pancreas 30(2)

      Pages: 191-2

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Chronic exposure to beta-hydroxybutyrate inhibits glucose-induced insulin release from pancreatic islets by decreasing NADH contents.2005

    • Author(s)
      Takehiro M
    • Journal Title

      Am J Physiology 282(2)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Distinct effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 on insulin secretion and gut motility.2005

    • Author(s)
      Miki T
    • Journal Title

      Diabetes 54(4)

      Pages: 1056-1063

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Nestin-positive cells in adult pancreas express amylase and endocrine precursor cells.2005

    • Author(s)
      Ueno H
    • Journal Title

      Pancreas 31(2)

      Pages: 126-31

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Gastric inhibitory polypeptide modulates adiposity and fat oxidation under diminished insulin action.2005

    • Author(s)
      Zhou H
    • Journal Title

      Biochem Biophys Res Commun 335(3)

      Pages: 937-942

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] ATP enhances exocytosis of insulin secretory granules in pancreatic islets under Ca^<2+>-depleted condition.2005

    • Author(s)
      Shimono D
    • Journal Title

      Diabetes Res Clin Pract 69(3)

      Pages: 216-223

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Autoantibodies against the exocrine pancreas in fulminant type 1 diabetes.2005

    • Author(s)
      Taniguchi T
    • Journal Title

      Pancreas 30(2)

      Pages: 191-192

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Chronic exposure to β-hydroxybutyrate inhibits glucose-induced insulin release from pancreatic islets by decreasing NADH contents.2005

    • Author(s)
      Takehiro M
    • Journal Title

      Am J Physiol 288(2)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Chronic exposure to beta-hydroxybutyrate inhibits glucose-induced insulin release from pancreatic islets by decreasing NADH contents2005

    • Author(s)
      Takehiro M
    • Journal Title

      Am J Physiolo 282(2)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Sulfonylurea and non-sulfonylurea hypoglycemic agents : pharmachological properties and tissue selectivity.2004

    • Author(s)
      Nagashima K
    • Journal Title

      Diabetes Res Clin Pract 66(supple 1)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Heparin-binding EGF-like growth factor induces expression of lectin-like oxidized LDL receptor-1 in vascular smooth muscle cells.2004

    • Author(s)
      Mukai E
    • Journal Title

      Athorosclerosis 176(2)

      Pages: 289-96

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Sulfonylurea and non-sulfonylurea hypoglycemic agents : pharmacological properties and tissue selectivity.2004

    • Author(s)
      Nagashima K
    • Journal Title

      Diabetes Res Clin Pract 66

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Heparin-binding EGF-like growth factor induces expression of lectin-like oxidized LDL receptor-1 in vascular smooth muscle cells.2004

    • Author(s)
      Mukai E
    • Journal Title

      Atherosclerosis 176(2)

      Pages: 289-296

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Sulfonylurea and non-sulfonylurea hypoglycemic agents : pharmachological properties and tissue selectivity2004

    • Author(s)
      Nagashima K
    • Journal Title

      Diabetes Res Clin Pract 66(supple1)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Gastric inhibitory polypeptide as an endogenous factor promoting new bone formation after food ingestion.

    • Author(s)
      Tsukiyama K
    • Journal Title

      Mol Endocrinol (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Gastric inhibitory polypeptide as an endogenous factor promoting new bone formation following food ingestion.

    • Author(s)
      Tsukiyama K
    • Journal Title

      Mol Endocrinol (in press)

    • Related Report
      2005 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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