Cooperative Effects of Isoflavones and Exercise on Bone and Lipid Metabolism in Postmenopausal Japanese Women.

• Project/Area Number: 16500536
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: National Institute of Health and Nutrition
• Principal Investigator: ISHIMI Yoshiko National Institute of Health and Nutrition, Division of applied Food Science, Laboratory Chief of Biological Function of Food Component., 食品表示分析・規格研究部, 室長 (50154159)
• Co-Investigator(Kenkyū-buntansha): TABATA Izumi National Institute of Health and Nutrition, Division of Health Promotion, Director, 健康推進研究部, 部長 (20188402) ; 呉 堅 独立行政法人国立健康・栄養研究所, 食品表示分析・規格研究部, 研究員 (40392534)
• Project Period (FY): 2004 – 2005
• Project Status: Completed (Fiscal Year 2005)
• Budget Amount: ¥3,200,000 (Direct Cost: ¥3,200,000); Fiscal Year 2005: ¥1,500,000 (Direct Cost: ¥1,500,000); Fiscal Year 2004: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: Isoflavone / Walking Exercise / Bone mineral density / Fat mass / Postmenopausal woman / Osteoporosis / 栄養調査 / 閉経後 / ウォーキング

Research Abstract

Introduction : The additive effects of isoflavones and exercise on bone and lipid metabolism have been demonstrated in estrogen-deficient animals. In this study, we determined the effects of isoflavone intake, walking exercise, and their interaction on bone, fat mass, and lipid metabolism over 1 year in postmenopausal Japanese women.
Methods : A total of 136 postmenopausal women at <5 years after the onset of menopause were randomly assigned to four groups : (1) placebo, (2) walking (45 min/day, 3 days/week) with placebo, (3) isoflavone intake (75 mg of isoflavone conjugates/day), and (4) combination of isoflavone plus walking. Bone mineral density (BMD), fat mass, serum lipid, and serum and urinary isoflavone concentrations were assessed.
Results : A significant main effect of isoflavone on the reduction in trunk fat mass was obtained at 12 months. Significant main effects of walking on the reduction in fat mass in the whole body and the trunk were observed at 3, 6, and 12 months and th at in the legs and arms at 6 and 12 months. Serum HDL cholesterol concentration significantly increased by 12 months following the walking and the combined intervention. After 12 months, a significant main effect of isoflavone on BMD was observed only at Ward's triangle. Walking prevented bone loss at the total hip and the Ward's triangle to significant degrees. The effect of the combined intervention on BMD and fat mass was greater than that of either alone. No significant interaction was observed between isoflavone and walking in any measurements recorded during the study.
Conclusion : Our study suggest that combined intervention of 75 mg/day of isoflavone intake and walking exercise 3 times/week for 1 year showed a trend for a greater effect on BMD at total hip and Ward's triangle regions than either alone. Intervention with isoflavone in postmenopausal Japanese women showed a modest effect on BMD when compared with those in the Westerners. Further studies over longer treatment duration that include assessment of BMD at various regions are necessary to ascertain the clinical significance of the combined intervention of isoflavone plus walking in postmenopausal women.

Research Products

• [Journal Article] Cooperative Effects of Isoflavones and Exercise on Bone and Lipid Metabolism in Postmenopausal Japanese Women : A Randomized Placebo-Controlled Trial (2006)
  • Author(s): Wu J, 0ka J, Higuchi M, Tabata I, Toda T, Fujioka M, Fuku N, Teramoto T, 0kuhira T, Ueno T, Uchiyama S, Urata K, Yamada Y, Ishim Y.
  • Journal Title: Metabolism 55・4 Pages: 423-433
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effects of Isoflavone and Exercise on Bone Mineral Density and Fat Mass in Postmenopausa1 Japanese Women : A One-year Randomized Placebo-controlled tria1 (2006)
  • Author(s): Wu J, 0ka J, Tabata I, Higuchi M, Toda T, Fuku N, Ezaki J, Sugiyama F, Uchiyama S, Yamada Y, Ishimi Y.
  • Journal Title: J Bone Mineral Res 21・5 Pages: 780-789
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Cooperative Effects of Isoflavones and Exercise Bone and Lipid Metabolism in Postmenopausal Japanese Women Randomized Placebo-Controlled Trial (2006)
  • Author(s): 21・5Wu J, Oka J, Higuchi M, Tabata I, Toda T, Fujioka M, FN, Teramoto T, Okuhira T, Ueno T, Uchiyama S, Urata K, Yam Y, Ishimi Y.
  • Journal Title: Metabolism 55・4 Pages: 423-433
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of Isoflavone and Exercise on Bone Mineral Density and Fat Mass in Postmenopausal Japanese Women : A One-year Randomized Placebo-controlled Trial (2006)
  • Author(s): Wu J, Oka J, Tabata I, Higuchi M, Toda T, Fuku N, Ezaki J, Sugiyama F, Uchiyama S, Yamada Y, Ishimi Y.
  • Journal Title: J Bone Mineral Res 21・5 Pages: 780-789
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cooperative Effects of Isoflavones and Exercise on Bone and Lipid Metabolism in Postmenopausal Japanese Women : A Randomized Placebo-Controlled Trial (2006)
  • Author(s): Wu J, Oka J, Higuchi M, Tabata I, Toda T, Fujioka M, Fuku N, Teramoto T, Okuhira T, Ueno T, Uchiyama S, Urata K, Yamada Y, Ishimi Y.
  • Journal Title: Metabolism 55・4 Pages: 423-433
• [Journal Article] Effects of Isoflavone and Exercise on Bone Mineral Density and Fat Mass in Postmenopausal Japanese Women : A One-year Randomized Placebo-controlled Trial (2006)
  • Author(s): Wu J, Oka J, Tabata I, Higuchi M, Toda T, Fuku N, Ezaki J, Sugiyama F, Uchiyama S, Yamada Y, Ishimi Y.
  • Journal Title: J Bone Mineral Res (in press)
• [Journal Article] Combined intervention of soy isoflavone and moderate exercise prevents fat elevation and bone loss in ovariectomized mice. (2004)
  • Author(s): Wu J, Wang X, Chiba H, Higuchi M, Ezaki O, Yamada Y, Ishimi Y.
  • Journal Title: Metabolism 53・7 Pages: 942-948
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] High bone mass gained by excrcise in growing mice is increased by subsequent reduced exercise. (2004)
  • Author(s): Wu J, Wang XX, Chiba H, Higuchi M, Yamada K, Ishimi Y.
  • Journal Title: J Appl Physiol 97・3 Pages: 806-810
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Equol, a metabolite of daizdein, Inhibits bone loss in ovariectomized mice (2004)
  • Author(s): Fujioka M, Uehara M, Wu J, Adlercreutz H, Yamada K, Ishimi Y.
  • Journal Title: J Nutr 134・10 Pages: 2623-2627
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] High bone mass gained by exercise in growing mice is increased by subsequent reduced exercise. (2004)
  • Author(s): Wu J, Wang XX, Chiba H, Higuchi M, Yamada K, Ishimi Y.
  • Journal Title: J Appl Physiol 97・3 Pages: 806-810
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Equol, a metabolite of daizdein, Inhibits bone 1 in ovariectomized mice (2004)
  • Author(s): Fujioka M, Uehara M, Wu J, Adlercreutz H, Yamada K, Ishimi Y.
  • Journal Title: J Nutr 134・10 Pages: 2623-2627
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Combined intervention of soy isoflavone and moderate exercise prevents fat elevation and bone loss in ovariectomized mice. (2004)
  • Author(s): Wu J, Wang X, Chiba H, Higuchi M, Ezaki O, Yamada Y, Ishimi Y.
  • Journal Title: Metabolism 53 Pages: 942-948
• [Journal Article] High bone mass gained by exercise in growing mice is increased by subsequent reduced exercise. (2004)
  • Author(s): Wu J, Wang XX, Chiba H, Higuchi M, Yamada K, Ishimi Y.
  • Journal Title: J Appl Physiol 97 Pages: 806-810
• [Journal Article] Equol, a metabolite of daizdein, Inhibits bone loss in ovariectomized mice. (2004)
  • Author(s): Fujioka M, Uehara M, Wu J, Adlerereutz H, Yamada K, Ishimi Y.
  • Journal Title: J Nutr 134 Pages: 2623-2627